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Biomedical subjects

F Valentini

Publications and source records attributed to F Valentini.

At least 37 records · Page 2Linked to original sources
PubMed1980

[Delivery by cesarean section under general anesthesia and the neurobehavioral assessment of the newborn infant].

The problem of the effects on newborns of the anaesthetics administered to the mother has been reviewed. For research purposes Pentothal, widely used for induction in Caesarean section was considered. In spite of the presence of fair quantities of this drug, as demonstrated by foetal blood withdrawn from the umbilical cord, the newborns examined and submitted to painstaking neuro-behavioral assessment using Brazelton's method, did not show any signs of neurological impairment nor diversity in behaviour compared to a control group.

Adult↗
PubMed1979

[Alterations of ventricular repolarization at rest, in young asymptomatic subjects. Diagnostic and predictive value of non-invasive methods].

In 34 asymptomatic subjects, aged 16 to 39 years, with clearcut abnormalities of ventricular repolarization on resting electrocardiogram, a forced hyperventilation and maximal exercise test were performed. The stress test was repeated, using the same protocol, after sublingual administration of nitroglycerin (0.3 mg) and of i.v. injection of propranolol (0.1 mg/Kg). In 24 subjects an echocardiogram was recorded: a mitral valve prolapse was present in 6 cases, while in 11 cases minor abnormalities were found. The response to exercise test was positive in 50% of cases. After nitroglycerin the ischemic threshold increased in 7 subjects while it remained unchanged or even lowered in 10 cases. In subjects with a negative stress test nitroglycerin did not produce any important electrocardiographic variations both at rest and during exercise. After propranolol injection the repolarization abnormalities on resting electrocardiogram disappeared or decreased in 23 subjects. The drug increased the exercise tolerance in 4 cases; in other 12 subjects the electrocardiographic response to stress testing became normal. During the follow-up period coronary events occurred in 3 cases; in all of them nitroglycerin had induced an increase of ischemic threshold. Our study suggests that the evaluation of the exercise ischemic threshold after nitroglycerin can be useful in order to identify subjects at high coronary risk.

Adolescent↗
PubMed1975

Inhibition of ACTH response to oral and intravenous metyrapone by antiserotoninergic treatment in man.

Plasma ACTH levels after oral and iv metyrapone administration were studied in 7 and 5 healthy women respectively both under basal conditions and after a 4-day treatment with metergoline, a specific antiserotoninergic agent. In 3 additional women, the effects of methysergide, another antiserotoninergic drug, on the plasma ACTH rise induced by oral metyrapone, were evaluated. A significant lowering of the plasma ACTH levels attained after either oral or iv metyrapone was observed following metergoline administration: 149+/-64.3 vs 239+/-49.1 pg/ml (mean peak values), P less than 0.05 in the oral test and 331+/-19.7 vs 221+/-19.5 pg/ml, P less than 0.02 in the iv test. The fall of plasma cortisol caused by metyrapone was comparable before and after the antiserotoninergic treatment. An interference of metergoline in the ACTH radioimmunoassay was also excluded. After metergoline administration, a slight reduction in the baseline plasma ACTH values was noted: 79+/-7.7 vs 67+/-7.7 pg/ml (NS). A decrease, however not statistically significant, of the metyrapone-induced plasma ACTH elevation occured after methysergide administration: 421+/-150.7 vs 344+/-135.1 pg/ml. These results can be interpreted as indicating that antiserotoninergic treatment caused an inhibition of hypophysial ACTH release in response to metyrapone. Caution is recommended, however, before concluding, on the basis of these findings, that serotonin as such plays a physiological stimulating role on ACTH secretion.

Administration, Oral↗