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Biomedical subjects

F Unger

Publications and source records attributed to F Unger.

At least 91 records · Page 5Linked to original sources
PubMed1985

The spindle pump--a new concept for a nonpulsatile bloodpump.

The spindle pump--a new nonpulsatile bloodpump--has been developed as paracorporeal ventricular assist pump. The experiments with calves clearly demonstrated, that this pump as LVAD empties the left ventricle completely, the aortic pressure curve showing the typical nonpulsatile profil. A problem is the traumatic hemolysis, the free hemoglobin was in all experiments slightly but always above our standard. To solve this problem we will optimize shapes of the spindle and of the housing and coate all parts of the pump with polyurethane.

Animals↗
PubMed1984

Syndrome of osteopathia striata, macrocephaly, and cranial sclerosis.

The combination of osteopathia striata, macrocephaly, and cranial sclerosis, variably associated with certain other congenital anomalies, constitutes a rare autosomal dominant malformation syndrome. A new case presented herein demonstrates the natural evolution of the syndrome in infancy and early childhood. Since the macrocephaly is likely to be the initial manifestation, the syndrome should be considered in the differential diagnosis of infants with unexplained macrocephaly.

Bone Diseases↗
PubMed1984

[The need for coronary surgery in Austria].

The coronary artery disease has a high incidence; 2500 patients per million population are dying of an acute myocardial infarction, 3000 people are suffering from an acute myocardial infarction annually. The aorto-coronary vein bypass is an established method and gains more importance, so that the operative incidence in the USA is annually up to 1000 per million population, in Europe up to 500. Based on these figures the incidence for Austria is calculated and would be up to 7500. The recent strategy of the treatment of an acute infarction in an acute "cardiac trauma center" is described. A cost-efficiency analysis is presented.

Austria↗
PubMed1983

[Intraoperative and postoperative course of enzyme activities in patients with angiographically closed and open aortocoronary bypass grafts].

30 patients who consecutively underwent cardiac surgery with extracorporeal circulation were investigated with regard to preoperative, intraoperative and postoperative activities of creatine kinase (CK) and CKMB isoenzyme (CK-MB), as well as myoglobin concentrations in the blood. 12 lead electrocardiograms were taken before and after the operation. At subsequent control angiography, of 18 patients with coronary heart disease 10 showed patent bypass grafts, whilst the remaining 8 patients had at least one occluded graft. 12 patients served as a control group, half of them undergoing mitral valve replacement and the other half aortic valve replacement. There was no significant difference in enzyme activity patterns between the groups. Specific determinations together with ECG monitoring can be of diagnostic help in perioperative control of these patients.

Aortic Aneurysm↗
PubMed1982

[Improvement of specificity in evaluation of aortocoronary bypass grafts by serial (dynamic) computed tomography (author's transl)].

Serial (dynamic) Computed Tomography (CT) with a non-periodic reconstruction of 21 images per minute improves specificity in evaluation of aortocoronary bypass grafts. In 35 bypass grafts, selective coronary arteriography was performed the day after CT: Sensitivity of CT-technique was 92%, specificity 89%. Without additional serial Ct, sensitivity was 85%, specificity 67%. Quantitative CT-measurements of flow equivalents showed no significant differences within two groups with angiographically displayed different "run off".

Coronary Angiography↗
PubMed1981

[Heart replacement (biventricular assisted circulation) with the ellipsoid heart (E-BVAD) (author's transl)].

At the present time mechanical assisted circulation is indicated in patients with cardiac failure after open heart operations. The results after clinical implantation of the left ventricular assist devices are not encouraging. However, most of these patients suffer from irreversible cardiac failure and no restitution is to be expected. In patients with postoperative cardiac failure, a distinction must be made between isolated left heart failure and total heart failure. In patients with total heart failure - for example with diffuse, marked coronary sclerosis - both left and right ventricle failure exists. In these patients, no left ventricular assist device per se can bring the desired effect, since due to the right heart failure syndrome, the left system does not work adequately. With the biventricular bypass it is possible to maintain complete circulation in cases of cardiac insufficiency. The cannulation concept is biventricular transatrial to the aorta or to the pulmonary artery. The technique is simple and can be carried out very quickly. In cases of clinical emergency this device can be recommended due to the satisfactory haemodynamic effects achieved and the small degree of traumatic haemolysis. It represents an easy and quick implantable system for total functional heart replacement.

Animals↗
PubMed1981

[Evaluation of coronary artery graft patency by computed tomography. Comparison with coronary arteriography (author's transl)].

In 14 patients with 19 coronary artery saphenous vein by-pass grafts (ACVB), computed transmission tomography has been performed the day before selective coronary angiography. Non-dynamic, contrast-enhanced sequential scans at 8-mm intervals were obtained starting at the cranial clips, ending at the left ventricle. CT scans were interpreted without knowledge of the catheterisation results. Sensitivity of this technique is 88%. Out of 17 ACVB patent by catheterisation, 15 ACVB are patent by CT. One occluded ACVB to the right coronary artery was thought to be patent by CT scan. This non-invasive technique shows promise as a method to follow up patients after ACVB-grafting.

Coronary Angiography↗
PubMed1980

[Acute implantation technique of the ellipsoid heart for clinical left ventricular assistance (author's transl)].

The results of the first clinical trials of left ventricular assist devices are not encouraging. The only indication at present is in patients with cardiac failure after cardiac operations. The acute type of ellipsoid heart described in this paper-displays a canulation technique where the inflow canula inserted in the left ventricular cavity via the left atrium and the outflow canula is directly connected to the aortic canula of the cardiopulmonary bypass. The haemodynamic response shows the efficacy of this system. The circulation can be maintained in severe cardiac failure, as well as in ventricular fibrillation and cardiac arrest. On the basis of data obtained in experiments on 7 female calves this system is considered worthy of clinical trial.

Aorta↗
PubMed1979

[The ellipsoid heart. Construction and animal experimental findings of a new kind of artificial heart].

In order to avoid thrombi generation within artificial ventricles the Ellipsoid heart is built with a one-piece membran in enddiastolic position. This allows to have an optimal washout of all inside surfaces during the cardiac cycles, in enddiastolic position the cross sectional veiw of the membran is circle-shaped. 82% of the filling volume can be used for the maximal stroke volume, which is 120 ml. The maximal cardiac output is 16 l/min. The Ellipsoid heart is evaluated as design for total heart replacement and assisted circulation. As total artificial heart the survival times were in calves experiments up to 40 days, in assisted circulation in parakorporeal position up to 83 days. The cardiac assistance with the Ellipsoid heart (E-LVAD) is performed due to implanted canula in the left ventricle via the left atrium and a connection to the ascending aorta. This technique was applied in 14 clinical cases with cardiac failure after open surgery. The E-LVAD could support the failing heart; it could be removed in 4 patients. The aim to avoid thrombiformation within artificial ventricles could be achieved with the Ellipsoid heart in calve experiments as well as clinically--the membrane was constantly clean and free of any thrombidepositions.

Animals↗
PubMed1979

[The research programme "Artificial Heart" at the 2nd Department of Surgery, University of Vienna: a ten year review (author's transl)].

The experimental and clinical results are presented of the research programme "Artificial Heart" carried out by the 2nd Department of Surgery, University of Vienna. In particular, an assessment of the clinical experience in 177 patients with the intra-aortic balloon pump is documented and it is concluded that only limited cardiac support is possible by this pump. In view of this fact more efficient methods of mechanical circulatory support, such as the interaortic auxilliary ventricle, the aortic "Windkessel" ventricle with guiding balloon, and two types of ventriculo-aortic bypass ventricle were tested with regard to their haemodynamic and long-time efficacy. The transatrio-aortic auxilliary ventricle (E-LVAD) was also clinically tested in 11 patients. In conclusion the problems of total mechanical heart replacement are discussed.

Animals↗
PubMed1979

[Influence on the programmed labour of some perinatological parameter (author's transl)].

In a critical analysis the obstetric results of individual induced labour (socalled "programmed labour") are compared with a series of births with spontaneous start of labour and of indicated induced deliveries. The results shows a much superior outcome of programmed labour: a shorter period of labour, a much reduced number of cesarean sections, a lower frequency of hypoxia, fewer newborn with pronounced Clifford-signs. The technical, personal and organisational efforts in modern obstetric is enormous increased. The induced labour is a possibility, this efforts to put into practice.

Apgar Score↗
PubMed1978

[Results of operative treatment of artial septal defect in the adult (author's transl)].

55 of 59 patients with artial septal defect, who had been operated in adult age, were examined postoperatively. The mean time interval from the operation was 43,8 months. Two patients had died immediately after the operation; there were no late deaths. The majority of the reexamined subjects was free of symptoms, in no case was there congestive heart failure. Persistence of postoperative symptoms increased with increasing age at the time of operation, but only up to the fourth decade of life. In 26 cases hemodynamics were examined. Mean pulmonary arterial pressure was normal at rest and during a slight ergometric load. In 5 patients there was moderate pulmonary hypertension. In 8 subjects there was minimal, in one patient moderate increase of pulmonary vascular resistance. Heartsize in chest roentgenogramm was increased in about 25% of cases, in more than 50% the pulmonary vessels were accentuated. Irregularities of cardiac rhythm were not more frequent postoperatively, than they had been prior to surgery. However, surgery was followed by a marked decrease of right axis deviation and of EKG signs of right ventricular hypertrophy. Pulmonary function studies revealed a slight decrease of vital capacity and of maximal breathing capacity. These results are favourable compaired to medically treated groups of patients as described in the literature. It is concluded, that even in later adult age the atrial septal defect as a rule is an indication for surgery.

Adult↗