Biomedical subjects

F Tsuda

Publications and source records attributed to F Tsuda.

168 records · Page 10Linked to original sources

PubMedDate not supplied

Hepatitis C and B virus infections in populations at low or high risk in Ho Chi Minh and Hanoi, Vietnam.

Inhabitants and patients of two cities in Vietnam were tested for antibodies to hepatitis C virus (anti-HCV), hepatitis B surface antigen (HBsAg) and antibody to HBsAg (anti-HBs). Anti-HCV was detected in 43 (9%) of 491 individuals without liver disease in Ho Chi Minh, more frequently (P < 0.001) than in 18 (4%) of 511 in Hanoi. There was no apparent age-specific distribution of anti-HCV. Among inhabitants of both cities, HBsAg and anti-HBs were frequent, detected in 10-14% and 35-37%, respectively; the prevalence of anti-HBs increased in parallel with age. Among individuals at high risk, the prevalence of anti-HCV was particularly high in drug users (58/67 or 87%) and patients on maintenance haemodialysis (15/28 or 54%) or with haemophilia (7/24 or 29%) in Ho Chi Minh, and in drug users in Hanoi (61/200 or 31%). Prevalence of HBsAg and anti-HBs in high-risk groups was not different from those in the general population. Screening of anti-HCV in blood donors in Vietnam is of urgent necessity because blood supply is dependent on commercial blood donors, many of whom are drug users at high risk.

Adult↗

PubMedDate not supplied

High prevalence of hepatitis B virus infection amongst Tibetans in Nepal.

Tibetans have been living in Nepal since 1959. Study of the prevalence of viral hepatitis among them showed that they have a high prevalence of hepatitis B virus (HBV) infection. Prevalence of total HBV infection and Hepatitis B surface antigen (HBsAg) among them was 61% and 16% compared to 10.0% and 0.7% respectively among the Nepalese. The predominant HBsAg subtype among the Tibetans was 'ayw'. Perinatal and childhood transmission was found important in the spread of HBV infection among the Tibetans.

Carrier State↗

PubMedDate not supplied

Hepatitis delta virus infection in Nepal.

Hepatitis Delta Virus (HDV) infection is very rare in Nepal. Anti-HDV antibody was detected in none of the 110 HBsAg sero-positive persons with different profile of HBV infection. It was however detected in only one patient of liver cirrhosis and hepatocellular carcinoma who were sero-negative for HBsAg but had serological evidence of past infection with HBV and HCV.

Adolescent↗

PubMedDate not supplied

Hepatitis B and C infection among drug abusers in Nepal.

Prevalence of hepatitis B and C virus infection amongst intravenous drug users (IDU) in Nepal is not known. To estimate such prevalence 72 IDU individuals were tested for HBV and HCV markers. About 80% of the drug abusers are both anti-HBc (59/72) and anti-HCV (58/72) sero-positive. However persistent infection with hepatitis B, as indicated by positive HBsAg, was detected in only 5.5% (n = 4). Active hepatitis C infection, as indicated by HCV RNA positivity, was documented in 74% (42/58) of those who were anti-HCV positive. Importance of awareness of this observation among the healthcare workers in the prevention of hepatitis C in the community is stressed.

Adolescent↗

PubMedDate not supplied

[Regularities in the spread of hepatitis C virus and its genotypes in Russian and countries within the former USSR].

The incidence of markers of hepatitis C virus (HCV in the blood of 4216 normal subjects living in the European Russia (Northern, North-Western, Central, Central Chernozem, Volga-Vyatka, Volga, and North Caucasian regions), in the Urals, in Siberia (Eastern Siberian region), in the Far East, and in Monogolia is assessed. The incidence of antibodies to HCV varied from 0.7% in the Central region to 3.8% in the Central Chernozem and 10.7% in Mongolia. HCV genotyping (identification of 1a, 1b, 2a, 2b, and 3a genotypes) was performed using 469 RNA of HCV-positive sera of donors and patients collected in Russia, Moldova, Turkmenistan, and Mongolia. The 1b genotype predominated everywhere (68.9%), its incidence being the highest in Moldova (96%). Unclassifiable variants of HCV were found in 28 (6%) of sera. The regularities of HCV genotypes circulation in the European Russia were the same as in other European countries, whereas their prevalence in Eastern Russia was rather like that in China or Japan. The prevalence of genotypes did not depend on the clinical manifestations of diseases caused by HCV.

Adolescent↗

PubMedDate not supplied

Epidemiology of hepatitis C virus infection in Nepal.

Prevalence of hepatitis C virus (HCV) infection in Nepal was studied by assaying sera from different population groups for anti-HCV by the second generation enzyme immunoassay method and for HCV RNA by polymerase chain reaction. The anti-HCV was positive in 0.6% of 2,860 healthy adults. HCV infection was responsible for 1.3% of acute viral hepatitis. Only drug addicts (DA) are known to have a very high incidence of the infection. The number of intravenous drug abusers (IDA) in Nepal have increased considerably since 1991 when buprenorphine (tidigesic) was introduced in the local market. About 72% of the drug addicts were found to be IDA and 94% of the IDA were anti-HCV positive. It is concluded that though the prevalence of HCV infection in the community is low, and at present it accounts for only a small number of acute and chronic liver diseases, the presence of a large number of DA in the country with high incidence of HCV infection may result in the emergence of HCV as an important cause of chronic liver disease in Nepal in future.

Adult↗