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Biomedical subjects

F Tsuchiya

Publications and source records attributed to F Tsuchiya.

At least 37 records · Page 2Linked to original sources
PubMed1994

[Primary transitional cell carcinoma in situ of the renal pelvis: a case report].

A 71-year-old female presented with left back pain at our hospital. She had had the same symptom about 1 year previously, but she had been presumed to have undergone stone passage because her symptom had disappeared. At this time a urogram, either excretory or retrograde, showed narrowing of each caliceal infundibulum and dilatation of each calyx in the left kidney, but otherwise normal findings. A cytology of left ureteral urine was class V, and cystoscopy revealed no abnormality. Under the diagnosis of left renal pelvic tumor she underwent nephroureterectomy with resection of a bladder cuff and retroperitoneal lymphadenectomy. The resected specimen had no gross tumor throughout the renal pelvis and ureter, but histological examination revealed transitional cell carcinoma in situ (grade 2) in most of the renal pelvis and infiltration of inflammatory cells in the submucosa. The ureter did not have any cancerous lesion, and no lymph node metastases was found. Four months postoperatively she is thought to have no evidence of disease with negative urinary cytology.

Aged↗
PubMed1994

[Late recurrence of renal cell carcinoma: report of three cases].

A 70-year-old woman underwent a left radical nephrectomy. The pathological examination revealed renal cell carcinoma (RCC), grade 1 and no lymph node metastasis. She suffered a recurrence in the renal fossa 11 years after the operation. The doubling time of the recurrent lesion was calculated to be very long for the cancer; about 1.3 years. Another case was in a 61-year-old woman, who underwent a right radical nephrectomy. The pathological examination revealed RCC, grade 1 with vascular invasion and no lymph node metastasis. Eleven years postoperatively she developed metastases in both lungs. The other case was in a 39-year-old woman, who underwent right radical nephrectomy. The pathological examination revealed RCC, grade 1 with vascular invasion and no lymph node metastasis. Eight years postoperatively she developed a recurrence in the left kidney. The doubling time of the recurrent lesion was about 0.9 year. All three patients responded to conservative therapy including interferon. Taking those doubling times into account, the recurrent lesions in the first and third cases seemed to have been growing very slowly and not rapidly immediately before clinically evident recurrence. Patients with a low grade RCC must have life-long followup.

Adult↗
PubMed1987

Effects of ethanol on adenylate cyclase system in the human platelet.

Effects of ethanol (EtOH) on the alpha 2-receptor-coupled adenylate cyclase (AC) of the human platelet were examined. EtOH increased "basal" AC activity in a linear dose dependent manner. In the presence of Gpp(NH)p (2.5 microM), however, the slope of the dose-response curve for EtOH stimulation of AC activity was biphasic. The increase in activity produced by the addition of EtOH concentration between 0 and 100 mM was much sharper than the increase in activity produced by the concentration in excess of 100 mM. EtOH increased the rate of activation of AC by guanine nucleotides and concomitantly decreased the concentration of magnesium required for half-maximal activation of AC. Prostaglandin-E1 (PGE1) alone stimulated AC activity. Clonidine (3 nM-1 microM) diminished the PGE1 (1 microM)-stimulated AC by a maximum of 30%. EtOH did not alter the concentration of clonidine required for half-maximal inhibition of AC. Our results suggest that the sites of EtOH's action can be assigned to the direct action of the catalytic subunit and to the Ns-protein. Our results also indicate a substantial difference in EtOH's action on catecholamine receptor systems coupled in a stimulatory versus inhibitory manner to AC. Stimulation of AC through Ns-protein is potentiated by EtOH, but inhibition of AC through the Ni-protein is little affected by EtOH.

Adenylyl Cyclases↗
PubMed1986

Neurochemical findings in the cerebrospinal fluid of schizophrenic patients with tardive dyskinesia and neuroleptic-induced parkinsonism.

Monoamine and their acid metabolites were determined in the CSF of 18 drug-treated chronic schizophrenic patients with the symptoms of tardive dyskinesia and neuroleptic-induced Parkinsonism (Parkinsonism). Six healthy volunteers were used as the control group. The norepinephrine (NE) levels were found to be significantly higher in the patients with tardive dyskinesia than in the controls. Furthermore, elevated CSF NE levels were also observed in the patients with Parkinsonism. Epinephrine (E) and Dopamine (DA) were not present in the CSF of the control group, whereas measurable levels of DA could be detected in 4 out of 9 and E was found in 8 out of 9 patients with tardive dyskinesia. The mean concentration of HVA was slightly but not significantly elevated in the patients with tardive dyskinesia and Parkinsonism. The mean values of CSF 5-HIAA were all within the normal range in both patient groups. From the above results, it was suggested that abnormal adrenergic activity rather than abnormal dopaminergic activity may play an important role as a mechanism in the etiopathogenesis of extra-pyramidal disorders. Furthermore, in the patients with Parkinsonism, CSF neurochemical observations were similar to those of the patients with tardive dyskinesia in this study. It may help to explain the clinical coexistence of tardive dyskinesia and neuroleptic-induced Parkinsonism.

Adult↗
PubMed1984

CT findings of atrial myxoma.

The computed tomographic (CT) appearance of six atrial myxomas was analyzed. Five of the myxomas were located in the left atrium and one was in the right atrium. The margin of the myxoma was at least slightly lobulated in five cases and the content was inhomogeneous in all. Calcification was demonstrated in three cases. The site of attachment of the myxoma was demonstrated by CT to be the atrial septum in all cases. The CT findings correlated well with the operative findings. CT revealed prolapse of the myxoma into the ventricle in two cases. This finding was similar to echocardiographic and cineangiographic findings. It is concluded that it is possible with CT to diagnose atrial myxoma by the location and nature of the intracardiac mass and to differentiate it from thrombus.

Adult↗