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Biomedical subjects

F Trotta

Publications and source records attributed to F Trotta.

At least 109 records · Page 6Linked to original sources
PubMed1982

[Comparative evaluation of 5 third-generation methods for the detection of HBsAg].

Five third generation methods for detection of HBsAg in serum were evaluation: AUSRIA II, Micro-RIA, Hepanosticon, Enzygnost, Antigen-TG. Sera of 340 patients with acute and chronic hepatitis and 160 controls were examined with these techniques. The haemoagglutination and latex tests were less sensitive than the RIA, Micro-RIA and ELISA methods. The RIA procedure remains the more sensitive, as demonstrated with sera diluted. False positive results, frequently depending on the excess of antibodies, were observed in ELISA, haemoagglutination and latex tests. The results confirm that the RIA procedure is still highly specific and sensitive, but ELISA is also a very alternative method for HBsAg detection.

Agglutination Tests↗
PubMed1981

[Association of non-secreting myeloma and ankylosing spondylitis. Considerations on a clinical case].

Connections between inflammatory rheumatic diseases and plasmacellular dyscrasias are still discussed. The observation of non-secretory IgA k myeloma occurred in a patient suffering by ankylosing spondylitis has induced us to do some considerations about the possible connections between these diseases and to stress the rarity of such association never reported in literature.

Agammaglobulinemia↗
PubMed1981

[Sensitivity and specificity of 2 methods of determining surface antigen (HBsAg) in various forms of hepatitis B pathology].

A passive haemoagglutination method (rHA) was compared to a solid-phase radioimmunoassay (RIA) in detecting hepatitis B surface antigen (HBsAg) in order to evaluate their sensitivity and specificity. The test was performed on sera from 297 subjects with acute and chronic hepatitis, 23 asymptomatic HBsAg-RIA positive carriers, 20 patients with infectious mononucleosis, 110 HBsAg RIA negative healthy persons; 30 sera positive for rheumatoid factor and/or autoantibody were also tested. Our data confirm that RIA is highly specific and rarely shows false negative results, depending on antibody excess, rHA shows less sensitivity than RIA in detecting HBsAg especially in sera of patients with acute hepatitis.

Carrier State↗
PubMed1980

[Reynolds syndrome associated with Sjögren's syndrome].

Observation of a case of CREST syndrome associated with autoimmune chronic hepatopathy (so-called Reynolds syndrome) and Sjögren's syndrome brings to the fore the importance of symptomatological superimpositions within the autoimmune diseases. A number of diagnostic and pathogenetic aspects of this rare disease association are discussed.

Aged↗
PubMed1978

[Phagocytic lymphocyte-like elements (PLLE) and irradiation in vitro].

The peripheral blood of rats contains lymphocyte-like phagocytes after intracardial injection of India ink. In vitro irradiation of whole blood (1000 r - 60Co), causes marked reduction in whole lymphocytes but does not modify the number and morphological integrity of the phagocytes, which can therefore be held to be comparatively radioresistant: as such, they could belong either to the mononucleate phagocyte system or to the lymphatic system (T4 lymphocytes). Since T-lymphocytes are not capable of phagocytosis, the former hypothesis would appear the most probable.

Animals↗
PubMed1978

Antilymphocyte antibodies in rheumatoid arthritis.

The presence of cold and non-cold reacting antilymphocyte antibodies of IgG class, active against allogeneic T lymphocytes deprived of Fcgamma receptor bearing cells, was investigated by indirect immunofluorescence (IF) and by microlymphocytotoxicity in 50 patients with Rheumatoid Arthritis (RA). 6/50 rheumatoid sera have shown the presence of anti-T-lymphocyte antibodies against 8/50 positivities found when the whole lymphocyte population was employed as the target in IF test. The positive sera were also examined by microlymphocytotoxicity test and the correlation with the number of lymphoid cells in peripheral blood was studied. In only one case (RA + Sjögren's syndrome) a positive IF test, in vitro cytotoxicity and in vivo lymphopenia were observed. In the other IF positive cases neither lymphopenia in vivo nor lymphocytotoxicity of the sera were observed; these results can be due to either the presence of cold or not complement fixing antilymphocyte antibodies.

Arthritis, Rheumatoid↗
PubMed1975

[Pyrasanone in the treatment of rheumatism].

The results of a set of experiments conducted on a new non-steroid antirheumatic preparation--pyrasanone (Carudol)--are presented and its indications in the general management of the disease are noted. The pharmacokinetics and therapeutic efficacy of the new drug are described. Statistical analysis showed it to be more effective than hexahydropyrazine, diphenylbutazone, indomethacin and oxyphenbutazone. A basic therapeutic approach is suggested in accordance with the pharmacodynamic aspects of the drug and the results observed in a clinical trial on 719 subjects. Pyrasanone has low toxicity and is well tolerated. Due caution in the administration of antirheumatic drugs should nevertheless be maintained during its use.

Adult↗
PubMed1975

[Osteopecilia].

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Adult↗