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Biomedical subjects

F Tosato

Publications and source records attributed to F Tosato.

At least 73 records · Page 4Linked to original sources
PubMed1983

[Basic therapy of rheumatoid arthritis with thiopronine. Preliminary results].

A long term open study of the use of thiopronine in the treatment of 38 patients with ARA classified "classic" or "definite" rheumatoid arthritis is reported. Doses of the drug were increased from an initial 250 mg per diem by the addition of 250 mg every 15 days to 1 g per diem. After 6 months testing, results were satisfactory (good and fair) in 65% of the cases in both biological and clinical terms. In 15% of the cases, treatment was interrupted mainly due to mucous and cutaneous side effects. These preliminary results confirm reports in the literature and encourage further experiment.

Administration, Oral↗
PubMed1979

[The role of fiberoptic bronchoscopy in the diagnosis of pulmonary cancer].

Cancer of the lung is becoming increasingly common. In the U.S., it has the highest mortality of the neoplastic diseases, well ahead of cancer of the colon and rectum. Surgical and/or complementary management is poorly effective because it comes too late. Early diagnosis and treatment are essential, therefore. Preclinical diagnosis may be possible radiographically in certain fortunate cases, but this is never an early diagnosis. The latter is only possible through active bronchial cytology (bronchial brushing, selective washing, PBS) during and after flexible fibrobronchoscopy, which can be carried out under local anaesthesia at the outpatient level and causes very little distress to the patient. Data from a personal series are cited in support of the view that cytodiagnosis should be routinely employed in subjects at high risk (heavy smokers, persons with chronic bronchitis, emphysema, etc.).

Adenocarcinoma↗
PubMed1978

[Possible influence of plasma factors on lymphocyte blastigenesis and E rosette forming in rheumatoid arthritis (author's transl)].

The lymphocytes blastigenesis to PHA in culture with autologous or normal plasma, the formation of E rosettes and the presence of immunoglob-lins on the lymphocytes surface were evaluated in 51 patients with chronic primary polyarthritis. While the percentage of T and B cells was almost normal (52.1 +/- 2.1% and 18.1 +/- 2.1%, N.V. 55.6 +/- 2.0% and 16.2 +/- 0.8%), the blastigenesis was significantly reduced in cultures with a 25% autologous plasma (5399 +/- 709 cpm compared to 13,182 +/- 920 cpm of the normal standard) and returned towards normal values when it was replaced by the plasma of a normal subject (12,189 +/- 1081 cpm). The rheumatoid plasma was capable of reducing the blastigenesis in 11 normal subjects (7395 +/- 750 cpm). The preincubation for 90' of the lymphocytes of 14 controls in rheumatoid or autologous plasma induced a significant reduction in the formation of spontaneous rosettes (40.8 +/- 1.4 % and 56.2 +/- 1.7%). These results suggest that the reduced function of the T lymphocytes in this disease is due to plasma factors.

Arthritis, Rheumatoid↗
PubMed1977

[Cellular immunity in sarcoidosis].

The characteristics of the circulating lymphocytes of 24 patients suffering from sarcoidosis were studied. The surface markers and the in vitro lymphocytic activity, both spontaneous and after stimulation with PHA, were assessed. Each culture was carried out in both homologous and autologous plasma. The stimulating ability of the plasma of sarcoidosis patients on normal lymphocytes was also evaluated. The patients were divided into two groups, i.e. acute sarcoidosis and sarcoidosis in remission. From this study it can be stated that depression of T-dependent immunity is particularly evident in patients with active disease. This depression seems to be mainly due to the presence in the plasms of factors which inhibit the cellular immune response.

Adult↗
PubMed1977

Spontaneous lymphocyte transformation in chronic lymphocytic leukaemia.

In ten patients with CLL and in eight controls T lymphocytes were separated out by the rosetting method. The in vitro reactivity of these cells and of unseparated lymphocytes was studied in cultures without stimulants. A net increase of spontaneous lymphocyte transformation was found in the populations enriched with T cells in patients with CLL with respect to analogous populations in the controls. This increase is interpreted as a cell-mediated immunological reaction and due to T-cell sensitization towards the neoplastic B cells.

Aged↗
PubMed1976

[Study of cellular immunology in malignant and benign monoclonal gammapathies].

In 25 cases of myeloma and 15 cases of benign paraproteinemia the functional situation of circulating lymphocytes was studied. The technique used was the incorporation of 3H-thymidine after PHA stimulation. E rosette formation and immunoglobulin bearing cells were evaluated. A reduction of 3H-thymidine incorporation in the blastic cells was seen in the patients with myeloma (the difference was statistically significant: p less than 0.001). In benign monoclonal gammopathies the reduction was moderate and was not statistically significant. The different blastic response in vitro in the two group of patients tested confirms that the respective immunocompetent systems clearly differ.

B-Lymphocytes↗
PubMed1976

Peripheral lymphocytes in paraproteinemia.

In 22 cases of myeloma and 12 cases of benign paraproteinemia the functional situation of circulating lymphocytes was studied. The technique used was the incorporation of 3H-Thymidine after PHA stimulation. E rosette formation and immunoglobulin bearing cells were evaluated. A reduction of 3H-Thymidine incorporation in the blastic cells was seen in the patients with myeloma (2,942 +/- 421 cpm/10(6) lymphocytes in respect to 13,182 +/- 920 of the control group). The difference was statistically significant: p less than 0.001. In benign monoclonal gammopathies the reduction was moderate and was at the limits of the significance: 9,482 +/- 1,100. The percentage of E rosettes and of immunoglobulins bearing cells was normal. The different behaviour of the blastic response in vitro in the two groups of patients tested confirms that the respective condition of the immunocompetent system is clearly different. A possible interpretation of this type of behaviour is discussed.

Antibody Formation↗
PubMed1976

[Stimulating effect of B-lymphocytes in mixed cultures on autologous T-lymphocytes in chronic lymphatic leukemia].

Two different cellular populations among the circulating lymphocytes were separated by using a technique based on the T lymphocytes capacity to form nonimmune rosettes with sheep red blood cells. The first population (P) is essentially composed of T lymphocytes, the second (population S) is made up mainly of type B lymphocytes. This technique was applied in the study of circulating lymphocytes in 11 patients with chronic lymphocytic leukaemia and was satisfactory both for good reproducibility and for its ability to obtain vital separate lymphocytes. Normal reactivity to PHA and PWM of population P and normal capacity to form E rosettes with SRBC were found. In mixed culture of T lymphocytes stimulated by B cells of the same patient significant blastic response was observed.

B-Lymphocytes↗
PubMedDate not supplied

[The diagnosis and therapy of dysphagic disorders of the LES].

Primary motor disorders of LES causing dysphagia consist in cardial achalasia and intermedius motor disorder (IMD), the last one different from achalasia because of normal motor pattern of the esophageal body. In this paper diagnostic and therapeutic procedures are examined according to an experience of 94 surgically treated cases (22 rioperations for surgical failures). Cardial dilatation as treatment of choice is recognized only for IMD in which a normal peristaltic behaviour of the esophagus can avoid the high danger of GER. Surgical procedure, now laparoscopically performed, consisting in Heller's myotomy + Dor partial fundoplication is to be preferred in cases of true achalasia.

Cardia↗
PubMedDate not supplied

[Ileal occlusion caused by enterolith migrated from Meckel's diverticulum].

The authors present a case report of an intestinal obstruction due to a relatively big coprolite migrated from a large Meckel's diverticulum to the distal Ileum. The patients apparently healthy and a vegetarian, complained on admission of the absence of emission of faeces and gas since four days before with noticeable abdominal distension. In the physical examination he presented intestinal meteorism, a hard abdomen, painful on deep palpation in the median quadrants, especially in the epigastric and mesogastric ones. The abdominal X-RAY in the standing position confirms: an occlusive state with numerous liquid levels in the Ileum. Because of a worsening of the symptomatology and the appearance of generalized comprimission, two days later an exploratory laparotomy was performed. The intervention showed the presence of a Meckel's diverticulum with approximately 10 cm in length, with an ample neck, the distal Ileum for approximately 15 cm in dilation returned rapidly to a normal calibre, after a pastous endoluminal formation borne in the Meckel's diverticulum (Meckel resection presented actually a large niche at the fundus level with a eroded wall) and migrated in the distal Ileum where it could cause the obstruction. In the present case it is probably useful to perform a preoperative CT scan in order to get a precise etiology and perform an ascending Colonscopy, so avoiding a surgical procedure. According to the authors a CT scan is indicated in all cases of intestinal occlusion of unknown case, in order to have a more precise definition of the physiopathology of the occlusion.

Calculi↗
PubMedDate not supplied

[Spontaneous retroperitoneal hematoma: a case report].

The A.A. present a case report of retroperitoneal spontaneous hematoma and put in evidence the difficulties in making an etiopathogenetic diagnosis of spontaneous renal cyst rupture. The patient was a 72 years old man admitted to the hospital in emergency for a painful ipogastric syntomatology and biliary vomit. The ecography showed a distanced gallbladder and the endoscopy evidenced a duodenal stenosis with compression of the gastric posterior wall, so that we were initially directed towards a pancreatic tumor even if the modest increase of the serum bilirubinemy and mostly the fact that direct component was almost normal, gave us strong doubts. The spiral TC gave finally the diagnosis of retroperitoneal hematoma and the presence of a bilateral polycystic kidney with several subcapsular cyst, let us suggest, as well as the anamnestic report of a physical stress, a renal origin of the bleeding. A wild literature review did not evidence other similar cases, but the ecclusion of other possible causes of retroperitoneal hematoma, suggested this conclusion.

Aged↗
PubMedDate not supplied

[Retroperitoneal mass: a clinical case].

The Authors discuss about a case of retroperitoneal mass, recently observed in their Institution. About the nature of the mass, by the imaging and clinical evolution, the Authors suppose a traumatic genesis: subcapsular renal hematoma, occurred 2 years before, broken and expanded in retroperitoneal space and then superficialized in the left lumbar region.

Aged↗