Biomedical subjects
F Tomík
Publications and source records attributed to F Tomík.
[On the problem of primary chronic myocarditis in idiopathic pulmonary hemosiderosis].
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[Histological changes in the gastric mucosa of dogs after repeated tetrachlormethane administration].
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[Reaction of the organism to two successive injections of tetrachloromethane].
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Amyloidosis in rheumatoid arthritis. A study of 48 histologically confirmed cases.
In a group of 269 patients with rheumatoid arthritis histological examination demonstrated amyloidosis in 48 cases, viz. in 7 post mortem cases, in 28 rectal biopsies, in 12 renal biopsies and in one liver biopsy. Examination for amyloidosis was carried out in all patients who had proteinuria, otherwise in non-selected patients with definite rheumatoid arthritis. Even through rectal biopsy is a valuable screening method, it should not be overestimated, because in 12 patients with renal biopsy positive for amyloid, the foregoing rectal biopsies had been negative. According to our experience the most valuable method for diagnosis of amyloidosis in rheumatoid patients is renal biopsy, whereas synovial biopsy is the least conclusive. This paper, according to our knowledge, is the first report on observations of a regression of the inflammatory activity of rheumatoid arthritis and nephrotic syndrome as well as a complete morphological regression of amyloidosis.