Search PubMed⌕ Search

Biomedical subjects

F Thuillier

Publications and source records attributed to F Thuillier.

27 records · Page 2Linked to original sources
PubMed1990

Selenium status prior to and during one month total parenteral nutrition in gastroenterological patients: A randomised study of two dosages of Se supplementation.

13 consecutive adult gastroenterological patients with non-malignant disease who were candidates for total parenteral nutrition (TPN), and who had mild protein-energy malnutrition (82 +/- 3% of ideal body weight, serum albumin 32 +/- 2 g/l, mean +/- SEM) were found to have, prior to TPN, a Selenium level 50% less than controls (p < 0.001) as assayed by Se and glutathione peroxidase (GSHPx) in plasma and erythrocytes. Compared with other trace metals and minerals, eg, Mn, Zn and Cu, depletion of Selenium was the most marked in this population. Patients were randomised to be supplemented with either 100 or 200 microg/d of sodium-selenite, equal to 32 microg (0.4 micromol) or 64 microg (0.8 micromol) of selenium, in two cross-over periods of TPN, each of two weeks. In this short term study, significant increases in the four measurements of Se status (p < 0.05) were seen in all patients, but there was no difference between those receiving the high or low dose of the element. GSHPx in plasma was normalised within 1 month whereas the increase seen in the erythrocyte pool was consistent with a 4-month half-life. Pooled Se values for patients and controls showed logarithmic correlations between Se and GSHPx in erythrocytes (p < 0.001) and plasma (p < 0.01). Changes in GSHPx provided further evidence of Se depletion in our patients. This study suggests that malnourished gastroenterological patients receiving TPN require Se supplements and that 100 microg (0.4 micromol)/d of sodium-selenite is adequate for most patients since there was no additional benefit from the higher dose of 200 microg (0.8 micromol).

Journal Article↗
PubMed1990

Effect of fat-emulsion phospholipids on serum lipoprotein profile during 1 mo of cyclic total parenteral nutrition.

Changes in serum lipoprotein determined by selective precipitation were investigated in 11 adult patients during 1 mo of parenteral nutrition. Patients were divided into two groups that received a similar nutrient regimen except for Intralipid (IL) phospholipid, which was higher in group A (10% IL, n = 5) than in group B (20% IL, n = 6), 139 +/- 15 vs 71 +/- 0.5 mg.kg-1.d-1 (P less than 0.01). Lipoprotein X (LPX) detected soon after IL infusions were started reached its highest concentrations in group A. LPX concentrations correlated with phospholipid intakes on days 7 and 15 but not on day 29. Significant increases in the cholesterol and phospholipid content of low-density-lipoprotein-very-low-density-lipoprotein fractions were observed only in group A. It is suggested that these changes were induced by the twofold-higher intake of phospholipids in group A. With regard to the possible involvement of LPX in lipid overloading of the reticuloendothelial system and hepatocytes, administration of 20% IL seems preferable to 10% IL.

Adult↗
PubMed1990

[D-lactic acidosis and encephalopathy in short-bowel syndrome occurring during antibiotic treatment].

A 24 year-old patient with a short-bowel syndrome receiving home parenteral nutrition in addition to oral feeding for 32 months was treated by oral trimethoprim-sulfamethoxazole for urinary tract infection. Three days later, he developed neurologic disorders associated with severe hyperchloremic acidosis and high plasma level of D-lactate. This is a rare complication of intestinal malabsorption due to small bowel by-pass or extensive resection due to transient alteration of intestinal microflora induced by the oral antibiotic treatment. Diagnosis requires a high indice of suspicion.

Acidosis, Lactic↗
PubMed1989

An alpha slow-moving high-density-lipoprotein subfraction in serum of a patient with radiation enteritis and peritoneal carcinosis.

An alpha slow-moving high-density-lipoprotein (HDL) subfraction was seen in a patient presenting with radiation enteritis and peritoneal carcinosis, who was given long-term cyclic parenteral nutrition. This subfraction, observed in addition to normal HDL, was precipitated with low-density lipoproteins (LDL) and very-low-density lipoproteins (VLDL) by sodium phosphotungstate-magnesium chloride. The patient's serum lipoproteins were analyzed after fractionation by density gradient ultracentrifugation. The alpha slow-moving HDL floated in the ultracentrifugation subfractions with densities ranging from 1.028 to 1.084 kg/L, and their main apolipoproteins included apolipoprotein E in addition to apolipoprotein A-I. These HDL were larger than HDL2. The pathogenesis of this unusual HDL subfraction is hypothesized.

Apolipoprotein A-I↗
PubMed1988

Pathophysiological study of diarrhoea in a patient with medullary thyroid carcinoma. Evidence against a secretory mechanism and for the role of shortened colonic transit time.

Intubation techniques and scintigraphic studies were used to determine the origin and mechanism of diarrhoea in a patient with medullary thyroid carcinoma, high plasma immunoreactive calcitonin and normal circulating serotonin, substance P and prostaglandins E2 and F2 alpha. Normal function of the small intestine was found for the following: (a) absorption tests; (b) water and electrolyte absorption in the proximal jejunum; (c) 24 hour flow rate and composition of fluid entering the colon and (d) gastric emptying rate and small intestinal progression of a normal meal. By contrast, colonic function was markedly impaired in three ways: (a) water absorption was decreased by half; (b) as the main excreted solutes were organic acids, a large electrolyte gap was recorded in faecal water, and (c) colonic transit time of the meal marker was very short, and was in agreement with the rapid transit of ingested radioopaque markers. These data strongly suggest that decreased absorption in the colon secondary to a motor disturbance is the main mechanism of diarrhoea in this case of medullary thyroid carcinoma, while calcitonin induced small intestinal fluid secretion suggested earlier is either non-existent, or only of minor importance.

Adult↗
PubMed1983

[Lipoprotein (a)].

Lp(a) or pre-beta 1-lipoprotein or Sinking pre-beta LP (SPB) is a special LP. Its very high density (1050 to 1120) means that it can be extracted from LDL and HDL. In common with the LDL, it possesses apo B and a similar size. It is characterized by the presence of specific apoproteins, non-immunoreactive albumin and a carbohydrate chain rich in sialic acid. Its transmission is hereditary; there is a major locus transmitted by autosomal dominant inheritance. Another hypothesis suggests that it is transmitted autosomally according to a polygenic mechanism for 75 p. cent of the molecule with superimposition of non-genetic elements for the rest. Lp(a) is not a product of Lp(b) metabolism; it is not transformed into any other LP and it does not exchange its apoproteins. Its synthesis is constant over time and its function is not yet known. Its assay depends on the antigenicity of the specific determinants of the apo Lp(a). Only radio-immunoassay is able to give values for any sample size especially for levels of less than 50 to 80 mg/l (respective limits of the EID and IDR techniques). It appears that a high Lp(a) level could constitute an additional risk to developing coronary heart disease and the limit beyond which this risk exists could be 300 mg/l in normolipidaemic subjects. The in vitro binding of LP to glycoaminoglycanes (GAG) could be a model for studying LP binding in vivo. It has been seen that, by the intermediary of a low concentration of Ca++ ions, the reactivity of Lp(a) to GAG was selective.

Blood Glucose↗
PubMed1983

[Assay of serum selenium by atomic absorption spectrophotometry. Value in the biological diagnosis of nonobstructive cardiomyopathies].

The authors present a technique of direct assay of serum selenium by atomic absorption spectrophotometry, using electrothermal atomization in a graphite oven. The initial results of the assays performed in patients with non-obstructive cardiomyopathies (NOCM) reveal a decrease in the serum selenium level. This element could therefore represent a laboratory marker for these diseases.

Cardiomyopathies↗