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Biomedical subjects

F Thervet

Publications and source records attributed to F Thervet.

At least 37 records · Page 2Linked to original sources
PubMed1985

Antidiuretic hormone response to volume depletion in diabetic patients with cardiac autonomic dysfunction.

Thirty-three insulin-dependent diabetic patients were separated into two groups from the results of three different tests for cardiac vagal neuropathy: heart rate response to deep breathing, Valsalva manoeuvre and heart rate response to postural change. Seventeen patients were considered as without ('intact' patients) and 16 as with ('denervated' patients) cardiac autonomic dysfunction. One patient with a transplanted heart was also studied. Plasma antidiuretic hormone (ADH), plasma aldosterone and plasma renin activity (PRA) were measured immediately before and 60 min after intravenous administration of frusemide and passage from lying to standing. The kinetics of hormonal responses were analysed more precisely (five blood collections) in six patients of each group who were studied again. Heart rate and blood pressure were recorded before each blood collection. Volume depletion estimated from the rise in plasma protein (+ 11.9 and + 12.2% in 'denervated' and 'intact' patients respectively) and heart rate response (+ 1.06 and + 14.7%) were similar in both groups. Mean blood pressure was unchanged in the 'intact' patients whereas it fell in the 'denervated' patients (-13.5%). PRA (+ 161.5 and + 231.2% in 'denervated' and 'intact' patients respectively) and plasma aldosterone (+ 318.2 and 279%) increased in both groups whereas plasma ADH was stimulated only in 'intact' patients (+ 55.3%).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1982

[Granulomatous histiocytosis in a 70-year-old woman, revealed by prolonged fever ; osseous lesions in the femur and tibia were associated with diabetes insipidus and hypernatremia (author's transl)].

The different patterns of histiocytosis X are usually classified into three forms according to their clinical and pathological expression. One form is acute and disseminated ; the two others are chronic, unifocal or multifocal. Borderline cases and intermediate forms can be seen. For instance, onset can be acute or subacute in chronic disseminated forms, such as Hand-Schüller-Christian disease ; acute or subacute exacerbations may occur during the course of the disease. We report an observation of this type which is remarkable for three reasons. Fever was the initial manifestation and remained apparently isolated for one year. Subsequent osseous involvement was limited to the femur and tibia. Hypernatremia developed as a result of both diabetes insipidus and disrupted thirst control. These unusual features of our case-report led us to review previously published data.

Aged↗