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Biomedical subjects

F Tanda

Publications and source records attributed to F Tanda.

At least 55 records · Page 3Linked to original sources
PubMed1989

Immunocytochemical profile of Kaposi's sarcoma cells: their reactivity to a panel of antibodies directed against different tissue cell markers.

Thirty-three cases of European Kaposi's sarcoma (KS) were investigated by immunohistochemical methods using a panel of antibodies specific for the markers of the cell types proposed for its histogenesis in the literature: S-100 protein for Schwann cells; lysozyme for histiocytes; alpha-actin, desmin and vimentin for pericytes and other mesenchyme-derived cells; factor VIIIR:Ag and Ulex europaeus agglutinin-I for endothelial cells. Antifibronectin antibodies were also used in order to investigate some functional activities of the proliferating cells. Immunohistochemical results showed that KS cells were diffusely positive for vimentin and alpha-actin and negative for all other cell markers. Furthermore, KS cells were constantly surrounded by fibronectin-positive material. Since the KS cells are diffusely positive for vimentin, they may be considered a monotypic proliferation of mesenchyme-derived cells which lack the markers of full endothelial cell differentiation; however, the occurrence of fibronectin-positive material around them suggests that these cells are actively proliferating endothelial cells and their diffuse positivity for alpha-actin suggests a possible differentiation to pericytic cells. In conclusion KS cells may be considered as mesenchymal cells which are at an intermediate stage of maturity or immaturity in vascular differentiation.

Actins↗
PubMed1989

Hyaline bodies in Kaposi's sarcoma: an immunocytochemical and ultrastructural study.

The nature of hyaline bodies (HB) in Kaposi's sarcoma (KS) has been investigated by electron microscopy (EM) and immunohistochemical methods. Paraffin sections from 45 cases of KS selected on the basis of their high content of HB were challenged with antisera against factor VIIIR:Ag, carcinoembryonic antigen (CEA), alpha-fetoprotein (AFP), alpha 1-antitrypsin (A1AT), fibrinogen, hemoglobin, alpha-actin and lysozyme. HB showed positivity for all the antibodies except for the last two. By EM, HB showed features consistent with red blood cell, fibrin and platelet phagocytosis. Therefore, HB in KS are considered to be the expression of an indiscriminate process of phagocytosis which involves not only erythrocytes and platelets, but also other substances such as fibrinogen, factor VIIIR:Ag, A1AT, CEA and AFP.

Antibody Specificity↗
PubMed1988

Angiosarcoma of the thyroid: a light, electron microscopic and histoimmunological study.

A histologic, histoimmunological, and ultrastructural study of a primary angiosarcoma of the thyroid gland is reported. The occurrence of neoplastic cells positive for Factor VIII-related antigen and Ulex Europaeus Agglutinin-I and the presence in their cytoplasms of Weibel-Palade bodies are consistent with this diagnosis. These findings further support the view that primary angiosarcoma of the thyroid is a distinct pathological entity and should no longer be interpreted as a variant of a poorly differentiated carcinoma.

Aged↗
PubMed1988

Toxic epidermal necrolysis in a patient affected by mixed essential cryoglobulinemia.

A patient with mixed essential cryoglobulinemia and polysystemic involvement developed cutaneous lesions characterized by erythematopurpuric maculae and blisters over his entire body. Such lesions appeared during the course of treatment with prednisone and cyclophosphamide when penicillin was added to the therapeutic regimen. The diagnosis of drug-related toxic epidermal necrolysis was made on the basis of clinical history and histologic features. The possible relationship with the underlying immunologic aberration and the active immunosuppression is discussed.

Complement C4↗
PubMed1988

Maxillary chondrosarcoma (report of two cases).

Two cases of chondrosarcoma of the maxilla are reported together with the clinical and histological differential diagnosis. The origin of this rare tumour in the maxilla, a bone with exclusive membranous ossification, is discussed in accordance with the new concept of cell differentiation in neoplasia.

Adult↗
PubMed1984

Fatal hyperpyrexia after withdrawal of levodopa.

We studied a patient affected with idiopathic Parkinson's disease and levodopa-induced dyskinesias. Fatal hyperpyrexia followed simultaneous levodopa withdrawal and a decrease in the dosage of diphenhydramine. The clinical features were those of the neuroleptic malignant syndrome. The rapid decrease in dopaminergic activity may have been important in causing the syndrome.

Basal Ganglia Diseases↗
PubMed1984

[The interposed jejunal loop after resection for gastric ulcer (endoscopic study)].

Authors refer about an endoscopic study concerning twenty patients who have been previously operated for gastric ulcer. In these patients it was performed a reconstruction of the alimentary canal by means of a gastro-duodenal interposition of an isoperistaltic jejunal loop. Authors show that this method has been proved valid to prevent duodeno pancreatic reflux in the residual gastric sac.

Adult↗
PubMed1983

Multicentric giant lymph node hyperplasia: an immunohistochemical study.

Biopsy specimens from five cases of multicentric giant lymph node hyperplasia were studied by standard histochemical techniques and by immunoperoxidase staining and double immunoenzyme labeling to determine the distribution of intracytoplasmic immunoglobulins and kappa and lambda light chains. Microscopically, the affected lymph nodes showed a nodular pattern characterized by multiple lymphoid follicles permeated by numerous small vessels. A striking proliferation of post-capillary venules with many plasma cells and immunoblasts was observed in the interfollicular areas. Immunoperoxidase staining revealed that the cells were positive for IgG, IgA, and IgM with both kappa and lambda chains in the normal ratio. The IgM-positive cells had a perifollicular distribution, whereas the IgG- and IgA-positive cells were located mainly in interfollicular areas. The presence and distribution of different classes of intracytoplasmic immunoglobulins seemed to reflect a normal, albeit tumultuous, immunologic response. Therefore, the disease can be considered a lymphoproliferative disorder due to an inappropriate immunologic reaction.

Aged↗
PubMed1983

Myofibroblasts in the epithelial-stromal junction of basal cell carcinoma.

The epithelial-stromal junction of basal cell carcinoma (BCC) has been investigated at the electron microscope level. The fibroblast-like cells surrounding the epithelial nests of BCC appear to be myofibroblasts. According to the present view of the function of myofibroblasts, their presence around BCC could be related to the slow invasiveness of this tumour.

Basal Cell Carcinoma↗
PubMed1982

Primary Kaposi's sarcoma and Hodgkin's disease in the same lymph node.

The occurrence of primary Kaposi's sarcoma in a lymph node affected by Hodgkin's disease is reported. The case concerns a 43-year-old woman with a recurrence of Hodgkin's disease 13 years after its initial diagnosis. In one of four excised supraclavicular nodes a Kaposi's sarcoma was unexpectedly found. The present observation stresses once more that the two diseases are closely related and possibly share the same pathogenesis.

Adult↗
PubMed1981

Role of 131Cs scan in preoperative diagnosis of nonfunctioning thyroid nodules.

The role of 131Cs scan in the preoperative diagnosis of cancer was evaluated in 355 patients with either cold or nonfunctioning thyroid nodules. Nodules were classified as positive, doubtful or negative by the pattern of isotope accumulation. Among 234 patients who underwent thyroidectomy, malignant lesions were found in 10.2 per cent of cases. All carcinomas but one found during surgery had been classified as positive by radiocesium scan and were considered as highly suspicious preoperatively; one carcinoma and two papillary adenomas had been classified doubtful and considered presumably malignant. False-positive nodules were found. However, we did not document histologically malignant lesions in nodules which were classified as negative by radiocesium uptake. The routine use of 131Cs scanning may be very useful in patients with cold or nonfunctioning thyroid nodules because of its high sensitivity in excluding malignant lesions.

Adenoma↗
PubMed1980

[The problem of cancer diagnosis in thyroid nodules: a study in an endemic area for goiter in North Sardinia].

In a 5-year prospective study in an endemic area for goiter, 275 patients with solitary thyroid nodules or with predominant nodules in multinodular goiters underwent surgery without selection on clinical grounds. The incidence of cancer was 13.1%. Preoperative diagnosis was based on personal history, local signs and radioisotope data. As compared with histologic findings, clinical and scanning data yielded a diagnostic accuracy of 19% and 31% respectively. 30% of all malignancies were not suspected preoperatively. 100% identification of cancer is possible only it all nodules are excised. Selection is, however, necessary: our data suggested that patients under 20 and over 50 years, all males, and goiters with more than 2 physical and/or scanning signs suspect for cancer should be operated upon. Much unnecessary surgery would be save and most, but not all, cancers would be excised.

Adolescent↗
PubMed1980

Haemangiopericytoma of the parotid gland. Report of a case and review of the literature.

A primary malignant haemangiopericytoma of the parotid gland is reported. Microscopically the tumour showed two different types of area: in the first a histologically benign haemangiopericytoma was present, in the second, separated from the former by a clear-cut border, the structure was that of a histologically malignant haemangiopericytoma which subsequently metastasized and killed the patient. The report stresses the great rarity of this neoplasm in the parotid gland and discusses the problem of the behaviour of haemangiopericytomas.

Hemangiopericytoma↗
PubMed1980

Multicentric giant lymph node hyperplasia. A hyperimmune syndrome with a rapidly progressive course.

A patient who had diffuse lymph node enlargement, fever, skin rashes, anemia and polyclonal hypergammaglobulinemia is described. Histologic examination of lymph nodes taken from different sites (cervical, axillary and inguinal) revealed the presence of giant lymph node hyperplasia. The liver and bone marrow showed a moderate lymphocytic and plasma cell infiltration. The clinical presentation of a multicentric variety of giant lymph node hyperplasia in the reported case is similar to the clinical features usually associated with angio-immunoblastic lymphadenopathy with dysproteinemia, indicating that these two disorders may be related and may affect the same organs and systems. Alternatively, this histologic reactive giant lymph node hyperplasia progressing with a rapid declivitous course can be considered distinctive of a separate entity.

Aged↗
PubMed1979

Acute agnogenic myeloid metaplasia with chromosomal abnormalities.

A case of a 37-year-old woman presenting with acute agnogenic myeloid metaplasia (AAMM) is described. The disease had a stormy course and was characterized by moderate splenomegaly, persistently depressed WBC counts, extramedullary hemopoiesis and presence of a high percentage of atypical myeloblasts in the peripheral smear. Platelets were persistently low, reticulocytes significantly below normal, notwithstanding anemia. Hot tended to fall progressively to intolerably low values in the absence of transfusion. The chromosomal mapping of peripheral blood revealed the presence of a trisomy of chromosome No. 8. This abnormality already demonstrated in two previous cases of acute myelofibrosis and the clinical course of the disease suggest that acute myelofibrosis and AAMM could be the same disease while chronic myelofibrosis should be considered a separate entity. Also, it is possible that AAMM with trisomy of chromosome No. 8 and stormy clinical course may be a different entity from the acute myeloproliferative disorders associated with other chromosomal abnormalities.

Acute Disease↗
PubMed1978

Synovial sarcoma of the soft palate: report of a case.

A case of primary synovial sarcoma of the soft palate is reported in a 19 year old man who was in good health and free of recurrence one year after operation. Radiation therapy was selected and a dose of 7600 rads was given. The presence of hyaluronic acid was investigated using the critical electrolyte concentration method. The tumor was considered histogenetically to be derived from undifferentiated mesenchymal tissue.

Adult↗