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Biomedical subjects

F Takenaka

Publications and source records attributed to F Takenaka.

71 records · Page 4Linked to original sources
PubMedDate not supplied

Myocardial fatty acid and cardiac performance.

Isoproterenol enhanced myocardial triglyceride utilization and incorporation of exogenous fatty acid into triglyceride fraction in the perfused rat heart in the presence of glucose. However, in the absence of glucose, cardiac performance was considerably aggravated by isoproterenol. This suggests that glucose might be an essential fuel in the heart stimulated by isoproterenol.

Animals↗
PubMedDate not supplied

Contribution of an electrogenic sodium pump to the response of sinoatrial node cells to acetylcholine.

ACh (10-7) - 10(-6) g/ml) induced hyperpolarization in pacemaker cells in the sinoatrial (SA) node of the rabbit heart varied inversely with the level of the maximal diastolic potential of the pacemaker cells. The hyperpolarization induced by ACh was completely abolished at 4 degrees -6 degrees C. Ouabain (10(-6) g/ml) markedly depressed or abolished the hyperpolarizing response. The response was also depressed in K-free solution, but not abolished. In Ca-free or low-Na solution, the sino atrial node cell responded well to ACh, showing marked hyperpolarization. Present results indicate that the hyperpolarization induced by ACh is at least in part due to an electrogenic Na pump activated by ACh.

Acetylcholine↗