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Biomedical subjects

F T Padberg

Publications and source records attributed to F T Padberg.

At least 55 records · Page 3Linked to original sources
PubMed1990

Reduced dependency on arteriography for penetrating extremity trauma: influence of wound location and noninvasive vascular studies.

Indications for arteriography in penetrating extremity trauma remain controversial. We reviewed our clinical experience in 454 patients (514 extremities) with penetrating trauma admitted during a prior 3 1/2-year period. Injuries were caused by stab wounds in 60 (11.7%) extremities and by gunshot wounds in 454 (88.3%) extremities. Thirty-three of the 60 stab wounds (55%) required urgent exploration, and 27 underwent arteriography. No arteriograms were positive for unsuspected arterial injury in this group. Forty-two of 454 gunshot wounds (9.3%) underwent mandatory exploration; arteriograms were performed on 412 extremities. Forty-four arteriograms (10.7%) demonstrated evidence of unsuspected arterial injuries. During the last year, randomly selected extremities (n = 23) have been studied with B-mode ultrasonography and segmental Doppler pressure measurements. Using the subsequent arteriography as the "gold" standard, sensitivity was 83% and specificity was 100%. Gunshot wounds were categorized according to location and positive arteriograms. Injuries to the lateral thigh and arm resulted in no positive arteriograms, while positive studies were observed in 11% of medial and posterior arm, 14% of antecubital fossa, 25% of forearm, 7.5% of medial and posterior thigh, 8% of popliteal fossa, and 26% of calf injuries. We recommend arteriography for gunshot injuries to identified high-risk areas, while clinical evaluation alone is accurate in all stab wounds to the extremities and gunshot wounds to the lateral thigh and outer arm. Preliminary data suggest expanded use of B-mode ultrasonography may further reduce our dependency on arteriography in these cases.

Adolescent↗
PubMed1990

Penetrating extremity trauma: identification of patients at high-risk requiring arteriography.

Indications for arteriography in patients with penetrating trauma to the extremities remain controversial. Some clinicians have recommended universal use of arteriography, whereas others prefer to rely on physical findings alone. To better define our indications for contrast studies, we reviewed clinical data on 306 patients (349 extremities) with penetrating trauma who were admitted during a prior 2-year period (1985 to 1987). Injuries were caused by stab wounds in 50 (14.3%) extremities and by gunshot wounds in 299 (85.7%) extremities. Twenty-seven of the 50 stab wounds (54%) required urgent exploration based on physical findings, whereas 23 underwent arteriography. None of these studies showed unsuspected arterial injury. Twenty-nine of 299 gunshot wounds (9.7%) underwent mandatory exploration, and arteriograms were performed on 270 extremities; findings in 30 studies (11.1%) were positive for unsuspected arterial injuries. Gunshot wounds were categorized according to location and number of arteriograms with positive results. Arteriograms of lateral thigh and upper arm injuries resulted in no positive outcomes. Positive study results were recorded in 22.9% of calf injuries, 20% of forearm and antecubital injuries, 9.5% of popliteal fossa injuries, 9.0% of medial and posterior thigh injuries, and 8.3% of medial and posterior upper arm injuries. We recommend arteriography for penetrating injuries to these high-risk areas. However, clinical evaluation alone is accurate for identification of arterial trauma with lateral thigh or upper arm wounds and stab wounds to the extremities.

Adolescent↗
PubMed1989

Dexamethasone attenuates microvascular ischemia-reperfusion injury in the rat cremaster muscle.

We examined the effect of dexamethasone (DXM) pretreatment on microvascular transport of macromolecules in ischemia-reperfusion injury. The rat cremaster muscle was splayed, placed in a Lucite intravital chamber, and suffused with bicarbonate buffer. The clearance of fluorescein isothiocyanate-dextran 150 (FITC-Dx 150) was measured as an index of microvascular transport. After determination of baseline data, the muscle was made ischemic for 2 hr by clamping its vascular pedicle, and subsequently reperfused for 2 hr. Ischemia-reperfusion produced a marked increase in clearance of FITC-Dx 150. After an initial peak of 13 times baseline value clearance fell to approximately 4 times baseline level 30 min into the reperfusion period. Clearance increased slowly throughout the remainder of the experiment, reaching 6 times baseline after 2 hr of reperfusion. The treated animals received DXM 3 hr prior to and immediately preceding the pedicle clamping. DXM reduced macromolecular clearance significantly after the first 30 min of reperfusion, and prevented the increase in clearance over time. After an initial peak, clearance values fell to near twice baseline in DXM-treated animals, and remained at this level for the 2 hr of reperfusion. Our data demonstrate that DXM attenuates the alternations in microvascular macromolecular transport produced by ischemia-reperfusion injury.

Analysis of Variance↗
PubMed1988

Lateral approach to the popliteal artery.

A lateral approach to the popliteal artery is described. The anatomic limits of the exposure, appropriate technical maneuvers to maximize this exposure, and alternative procedures are discussed. Groin or thigh infections in patients requiring urgent revascularization are the most common indications. However, some traumatic injuries and certain elective reconstructions are appropriately treated with this technique. The lateral exposure to the popliteal artery is not technically demanding and offers a useful alternative for treatment of selected vascular problems.

Adult↗
PubMed1988

Technetium 99m pyrophosphate quantitation of skeletal muscle ischemia and reperfusion injury.

The study of ischemia and reperfusion injury in the extremity has been hampered by lack of an accurate method of measuring skeletal muscle injury. We used a bilateral isolated in vivo canine gracilis muscle model in 15 anesthetized dogs. The experimental muscles had 4, 6, or 8 hours of ischemia and 1 hour of reperfusion. The contralateral gracilis muscle served as a control. Technetium 99m pyrophosphate (99mTc-PYP), an agent which localizes in injured muscle cells, was used to quantitate canine skeletal muscle damage. After 6 hours of ischemia and 1 hour of reperfusion, there was a significant increase of 215% of 99mTc-PYP uptake in the experimental vs the control muscle. Experimental muscle uptake was 8% greater than control after 4 hours and 405% more after 8 hours of ischemia and reperfusion. Segmental distribution of 99mTc-PYP uptake showed localization to be greatest in the middle of the muscle at the entry site of the gracilis artery. Electron microscopic evaluation also documented this area to have undergone the most severe injury. Distal portions of the muscle did not show increased damage. Our results show that 99mTc-PYP effectively quantitates skeletal muscle ischemia and reperfusion injury. The pattern of 99mTc-PYP uptake suggests that considerable injury is caused during reperfusion.

Animals↗
PubMed1987

Vascular complications related to drug abuse.

Vascular complications resulting from drug abuse constitute a widespread and common clinical problem. A 3-year experience with 32 vascular complications (13 arterial, 19 venous) related to intravenous drug abuse is reported. Fourteen (48%) of the 29 patients in this series presented with septic vascular complications. These infections were a major cause of morbidity and mortality, resulting in two hospital deaths and a disrupted arterial repair. In addition, intra-arterial drug injection caused digital gangrene in two patients. Early recognition, diagnostic arteriography and venography, and planned therapeutic interventions are possible if a high level of suspicion is maintained.

Adult↗
PubMed1986

The value of laser Doppler velocimetry and transcutaneous oxygen tension determination in predicting healing of ischemic forefoot ulcerations and amputations in diabetic and nondiabetic patients.

The ability to predict successful healing of ulcerations and amputations of the ischemic forefoot continues to be a major clinical challenge, particularly in diabetic patients whose systolic Doppler ankle pressures are often artifactually elevated. We have used the techniques of laser Doppler velocimetry (LD) and transcutaneous oxygen tension monitoring (tcPO2) to quantitatively measure skin blood flow in the distal foot. Fifty-nine limbs were studied (48 patients), of which 37 (63%) were in diabetic and 22 (37%) in nondiabetic patients. All patients were admitted with ischemic ulcerations or gangrenous changes of the forefoot or digit. Twenty transmetatarsal or digital amputations were performed; the remainder of the lesions were débrided and allowed to heal by secondary intention or were covered by a skin graft. Before operation, the systolic pressure (expressed in millimeters of mercury, mean +/- SEM) was measured by Doppler technique at the ankle, and the ankle/arm index calculated (n = 59 limbs). The tcPO2 (also expressed in millimeters of mercury, mean +/- SEM) was measured from the dorsal foot (n = 56). The baseline skin blood flow velocity (SBFV) and pulse wave amplitude (PWA) were measured with the LD (expressed in millivolts, mean +/- SEM) on the plantar aspect of the foot (n = 53 limbs). Criteria for successful healing included a tcPO2 of more than 10 mm Hg, the combination of an LD-SBFV of more than 40 mV and an LD-PWA of more than 4 mV, and an ankle systolic pressure of more than 30 mm Hg.(ABSTRACT TRUNCATED AT 250 WORDS)

Amputation Stumps↗
PubMed1985

Selection of patients for lumbar sympathectomy.

We successfully predicted that patients presenting with critical ischemia of a limb and Doppler ratios greater than or equal to 0.3 would benefit from lumbar sympathectomy alone. However, we found that the procedure failed in 14 per cent of limbs whose ratios were greater than or equal to 0.3. In retrospect, all these patients were found to have deep infection. Had we known this fact prospectively, our predictions for success would have been close to 100 per cent. We were less than 50 per cent successful in predicting failure of the procedure, but the number of patients in this group is too small to draw reliable conclusions. We believe that patients with arm-ankle Doppler ratios greater than or equal to 0.3 whose manifestations of ischemia are limited to the skin will have a greater than 95 per cent chance of receiving a good result from lumbar sympathectomy alone and that this result will be maintained for many years.

Aged↗
PubMed1985

Results of revascularization and amputation in severe lower extremity ischemia: a five-year clinical experience.

Aggressive revascularization of the ischemic lower extremity in atherosclerotic occlusive disease by femoropopliteal (FP) and femorotibial (FT) bypass or profundaplasty (P), as indicated, has been advocated by some authors for all patients. Others have recommended primary amputation, particularly for tibial occlusive disease. To clarify this clinical dilemma, we reviewed the results of 547 procedures performed during the last 5 years: revascularization in 375 (69%) instances and below-knee amputation (BKA) in 172 (31%) cases. Bypass procedures were used in 246 cases: FP in 155 (64%) and FT in 91 (37%). Reversed autogenous saphenous vein (ASV) was used preferentially in 125 (51%) cases, whereas polytetrafluoroethylene (PTFE) was used in 121 (49%) cases. P was performed in 129 instances accompanied by inflow procedures in 92 (71%) of these cases. Cumulative limb salvage (LS) exceeded bypass patency in all categories and resulted in 2- and 5-year LS rates of 83% and 81% for FP with the use of ASV and 52% and 35% for PTFE. The LS rate for FT was 53% and 47%, respectively, for ASV and 20% and 15% for PTFE. Rest pain was successfully relieved by P in 99 cases (77%), whereas healing occurred in only 51% of cases with tissue loss. The perioperative mortality rate for revascularization was 3%; 42% of the group died during follow-up, death usually resulting from complications of atherosclerosis. Of the 172 BKAs, primary healing occurred in 80%, but the perioperative mortality rate was 13%. FP and FT bypasses are preferred procedures if ASV is available, whereas use of PTFE should be limited to FP bypasses only. Rest pain is relieved by P but tissue loss should prompt consideration for bypass. BKA should be considered in cases of severe tibial disease only in the absence of a suitable ASV, as the perioperative mortality rate is high and ultimate rehabilitation (64%) is limited.

Amputation, Surgical↗
PubMed1985

The role of contrast arteriography in suspected arterial injuries of the extremities.

The records of 215 patients presenting with 218 penetrating or blunt injuries to the extremities from 1977 through 1983 have been reviewed. All patients presenting with pulsatile hemorrhage, expanding hematoma, or absent distal pulses were explored immediately. Patients with injuries in close proximity to a major artery but without classical signs of arterial injury were explored routinely from 1977 through 1980. Thereafter, similar patients were evaluated initially with contrast arteriography and explored only if arteriographic abnormalities suggested arterial injury. Routine exploration of proximity injuries has been compared with selective exploration based on contrast arteriography. Sixty-one patients (group 1) underwent routine exploration for proximity injuries. Vascular injuries were detected in ten (16%) patients, while 51 (84%) of the explorations were negative. Eighty-four patients (group 2) with proximity injuries were studied arteriographically. Ten patients (11.9%) were explored on the basis of abnormal arteriograms, and eight arterial injuries were confirmed. Two (2.4%) of the 84 patients in this group had negative explorations. The use of contrast arteriography enabled the authors to reduce their negative exploration rate from 84 to 2.4 per cent in the management of proximity injuries.

Adolescent↗
PubMed1985

Simultaneous determination of brachial and femoral arterial pressures during reactive hyperemia and papaverine vasodilation.

Accurate assessment of aortoiliac occlusive disease often requires direct intraarterial pressure determination. Since these measurements may alter systemic pressure, brachial arterial pressure (BAP) and femoral arterial pressure (FAP) were obtained simultaneously to quantitate these changes. BAP and FAP were measured at rest, and then during vasodilation produced by postischemic reactive hyperemia and intra-arterial injection of papaverine. The gradient between FAP and BAP was used to assess the significance of an aortoiliac stenosis. Sixty-eight observations were performed in 19 limbs. During reactive hyperemia (n = 28), BAP was 142 +/- 7 mm Hg, which was not significantly different from the baseline BAP of 142 +/- 5 mm Hg. However, during thigh tourniquet inflation, BAP increased significantly to 158 +/- 7 mm Hg. Following papaverine injection (N = 21) BAP was 144 +/- 8 mm Hg, which was significantly different from both the baseline BAP (150 +/- 6 mm Hg) and the preinjection BAP (156 +/- 6 mm Hg). Postischemic reactive hyperemia and papaverine vasodilation produced comparable brachial to femoral pressure gradients. Use of baseline BAP is recommended for calculating gradients during reactive hyperemia, since the BAP is significantly elevated during tourniquet occlusion. Simultaneous recording of brachial and femoral pressures is recommended with intra-arterial papaverine injections, since the BAP varies significantly throughout the examination.

Aortic Diseases↗
PubMed1984

Revascularization of the profunda femoris artery for limb salvage.

The clinical outcome of 88 profundaplasties in 70 patients operated upon during the period 1978 to 1982 was related to indications for operation, status of arterial run-off, influence of a concomitant inflow procedure, and changes in Doppler ankle-brachial index (ABI). Operative procedures were performed for rest pain (49 limbs), ulceration (24 limbs), and gangrene (13 extremities). Primary profundaplasty (PP) was performed in 26 (29%) cases. Sixty-two procedures (71%) were inflow profundaplasties (IP) performed in conjunction with other proximal reconstructions. Overall clinical success was achieved in 67 extremities (76%). When the operation was performed for rest pain, and the arterial run-off was good, success rate was 78 per cent and 79 per cent, respectively, as compared to 51 per cent and 57 per cent for ulceration/gangrene and poor arterial run-off. For PP, satisfactory outcome was noted in 69 per cent as compared to 79 per cent in IP. In the clinically successful profundaplasties, mean preoperative ABI was 0.29 and increased significantly to 0.53 postoperatively (P = 0.04). In the clinical failures, mean preoperative ABI was 0.32, and postoperative ABI was 0.38, which was not statistically significant (P greater than 0.05). Profundaplasty is a reliable operation particularly when the indication is rest pain, and the arterial run-off is good. Poor results can be anticipated when the procedure is performed for tissue loss, or if the arterial run-off is poor. Clinical outcome for the PP and IP groups were comparable.

Aged↗
PubMed1984

Popliteal and infrapopliteal arterial injuries. Differential management and amputation rates.

A 3-year clinical experience is analyzed to define preferred surgical management and amputation rates for popliteal as well as infrapopliteal arterial injuries. Ten patients with popliteal arterial trauma were successfully managed without amputation, however, five of 11 (45%) patients with infrapopliteal arterial trauma required amputation. While essentially all popliteal arterial injuries mandate repair, recommendations for repair or ligation of isolated tibial arterial injuries are based on presence of distal ischemia, the patient's associated injuries, as well as estimated operating time for reconstruction. With injury to two or three infrapopliteal arteries, distal ischemia is usually present and arterial repair indicated, unless there has been severe crush injury, prolonged delay, or extended surgery would jeopardize the patient's life. A management protocol for patients with distal ischemia related to popliteal or infrapopliteal arterial trauma should include prompt surgical intervention, liberal use of fasciotomy, intraoperative arteriography, as well as the selective use of intraluminal shunts.

Adolescent↗
PubMed1984

Penetrating carotid arterial trauma.

Injury to the carotid arteries from penetrating occurred in 15 patients during a recent 4-year interval. Fourteen of the injuries involved the common and/or internal carotid arteries, while one isolated external carotid injury was also encountered. Gunshot wounds accounted for eight injuries (53%) and sharp-edged instruments for seven injuries (47%). Surgical management included six ligations and nine vascular repairs. Neurologic status was normal on admission in eight patients, all of whom did well. Seven patients had preoperative neurological deficits; all three mortalities occurred in these patients. Identification of a preoperative deficit is significant because it conferred a guarded prognosis. However, hypotension and even circulatory arrest did not preclude recovery.

Adolescent↗
PubMed1983

Carotid body tumor. The Lahey Clinic experience.

We believe that paragangliomas of the carotid body should be excised in all patients unless formidable medical conditions prohibit the use of general anesthesia. If these tumors are left unresected, they will eventually grow to invade the skull and kill the patient. With definitive diagnostic modalities available, in addition to comparatively low-risk anesthesia, autotransfusion, and replacement of the carotid artery, there are few patients who cannot be surgically treated. The important point is that although such a tumor is rare, its presence must always be considered when dealing with a lateral neck mass. Carotid arteriography should be performed when a carotid body tumor is suspected.

Carotid Arteries↗
PubMed1983

Femoral venous trauma: techniques for surgical management and early results.

During a 4 year period (1979 through 1983), 181 major arterial (69 percent) and 81 venous (31 percent) injuries were treated surgically. Of the venous injuries, 24 (30 percent) involved the femoral veins (9 common femoral, 15 superficial femoral). Management of these femoral venous injuries included lateral venorrhaphy in 10 cases (42 percent), venous patch angioplasty in 5 cases (21 percent), end-to-end anastomosis in 4 cases (17 percent), interposition autogenous saphenous vein grafts in 3 patients (12 percent), and ligation in 2 cases (8 percent). One case that included common femoral venous ligation and one that included a failed interposition saphenous vein graft in the superficial femoral vein subsequently were managed with in situ saphenous vein bypass. For one interposition saphenous vein graft repair of the common femoral vein we utilized the spiral vein graft technique. Excluding one early death from associated injuries and one superficial femoral venous injury managed by ligation without postoperative complications, 17 of 23 (74 percent) femoral venous repairs were judged patent postoperatively (13 confirmed by venography and 4 by noninvasive testing). The adjuvant use of intermittent pneumatic calf compression and low molecular weight dextran appears to have been beneficial in maintaining patency of the femoral venous repairs. Early clinical follow-up demonstrated the presence of edema in 6 of 8 cases (75 percent) initially treated by ligation or complicated by postoperative occlusion. Early postoperative edema, present in 4 of 17 (24 percent) patients with patent venous repairs, had resolved by the time of discharge. We recommend routine repair of femoral venous injuries. When significant edema or ischemia develop following obligatory venous ligation or postoperative occlusion of a venous repair, revision or venous bypass should be considered.

Adolescent↗
PubMed1981

Central venous catheterization for parenteral nutrition.

To define the risks associated with central venous catheterization for total parenteral nutrition (TPN) 3291 patient days of this therapy, delivered by an established nutrition support team, were evaluated. One hundred and seventy-five catheters placed in 104 patients were reviewed over an 18 month period. Positive cultures were reported on 11 cannulae for a 6.4% incidence of colonization; five catheters (2.8%) were considered septic. Pleural or mediastinal complications of subclavian or internal jugular venipuncture occurred in eight patients (4.8%). Misdirection of the catheter tip occurred in 11.5% of insertions. Five patients (4.8%) had clinically apparent thrombosis in the superior vena cava, innominate and/or subclavian veins during hospitalization; four others had evidence of thrombosis at autopsy examination, giving an incidence of 8.7% in the entire series. No death directly resulted from the use of this therapy. Compliance with a rigid protocol by an experienced team can allow safe and effective use of central venous catheters and parenteral nutrition therapy.

Bacterial Infections↗