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Biomedical subjects

F Strian

Publications and source records attributed to F Strian.

At least 55 records · Page 3Linked to original sources
PubMed1985

[Early diagnosis of autonomic diabetic neuropathy using sensitivity to temperature].

Testing temperature sensitivity thresholds and sensory nerve velocity in 76 type I diabetics and 16 healthy controls gave the following results: In 24 patients with dysfunction of one or more autonomic nervous system functions (histamine test reaction, erectile impotence, gastroparesis, orthostatic hypotension and bladder atonia) temperature sensitivity of the lower limbs, as an early manifestation of distal diabetic neuropathy, was markedly impaired compared with healthy controls as well as patients without autonomic dysfunction (n = 52); sensory nerve velocity (sural nerve) was similar in the two groups; metabolic parameters (blood glucose 1 hour postprandial morning and noon; glucose in 24-h urine, and HbA1a-c) also failed to demonstrate any difference between the two patient groups.

Adolescent↗
PubMed1985

Subjective sensitization to tonic heat as an indicator of thermal pain.

In 144 healthy subjects tonic heat stimuli were applied with a contact thermode and systematically varied with respect to 3 parameters: temperature T, rate of temperature change RTC, and duration D. In addition, the stimulus temperature at which the first sensation of pain occurred was produced by some subjects. In both types of experiments, subjects compared heat intensity felt at the beginning and the end of the stimulus and then set stimulus temperature to correspond with their initial sensation. The direction of this temperature change (delta T) indicates whether the subject senses an augmentation or a diminution of heat intensity. There was a parallel occurrence of pain and sensitization to sustained heat. The average skin temperature of the point of transition from adaptation to sensitization was equal to the average pain threshold temperature. The temperature change response maintained individual differences of thermal and pain sensitivity and was highly consistent for each subject. Potential applications of the procedure in clinical and experimental pain research are discussed.

Adaptation, Physiological↗
PubMed1984

[Proof of TNS effect using experimental heat pain].

By means of experimentally induced heat pain, the effectiveness of transcutaneous electrical nerve stimulation (TNS) was studied in 51 healthy volunteers. TNS produces an elevation of the lower range of sensitiveness to pain ("elevated pain threshold") and hence pain relief. The findings are compared with neurophysiological results from leads of polymodal human C-fibres and spinothalamic tract (dorsal horn) neurons. Their importance for clinical pain syndromes is discussed.

Adult↗
PubMed1984

Anxiety and depression in affective disorders.

Anxiety and depression were assessed with self-rating and observer-rating scales on admission and at discharge in 414 inpatients with endogenous or neurotic depression, anxiety neurosis or phobic disorders. The results were compared with findings in a reference group of 2,493 inpatients with a wide range of psychiatric disorders and a representative sample of the general population consisting of 1,952 persons. On admission the patients with anxiety neurosis and all of those with depressive disorders were significantly more anxious than the psychiatric reference group, whereas the phobic patients were only slightly more anxious. As was to be expected, the depressive groups showed the greatest depressivity, whereas the group with anxiety neurosis differed only slightly from the psychiatric reference group and the patients with phobias were actually below this reference group. During the treatment period there was a marked decrease in anxiety among the depressive patients but not in those with anxiety neurosis. The decrease in depressivity in the neurotic depressive patients was much less than in those with endogenous depression. Mixed anxiety depression was found with about the same frequency in both the neurotic and the endogenous depression groups. In general, anxiety and depressivity decreased over the treatment period, with persistence greatest in the anxiety neurosis group. On admission there was a more pronounced connection between anxiety and psychomotor agitation, on discharge between anxiety and psychomotor retardation.

Adult↗
PubMed1984

[Dysmorphophobia as a contraindication for cosmetic operations].

Dysmorphophobic patients are unreasonably concerned about their appearance and show an extreme lack of self-confidence and self-identity. In most cases dysmorphophobic symptoms indicate hidden communication problems. Schizophrenic psychosis is not uncommon in these patients. Dysmorphophobia contra-indicates surgical operation.

Adaptation, Psychological↗
PubMed1983

Anxiety in schizophrenic psychoses.

Anxiety and depression were assessed with self-rating and observer-rating scales on admission and at discharge in 225 inpatients with hebephrenic, catatonic, paranoid or residual schizophrenia. The control subjects were 104 patients with endogenous depression and 63 with anxiety neurosis. The results were also compared with findings for a reference group of 2493 inpatients with a wide range of psychiatric disorders and a representative sample of the general population consisting of 1952 persons. On admission the group of schizophrenic patients was markedly more anxious than the group of healthy persons, slightly less anxious than the psychiatric reference group and much less anxious than the group with endogenous depression and anxiety neurosis. Anxiety correlated significantly with acute paranoid symptoms, whereas depression dominated just prior to discharge, when the acute symptoms had subsided. This indicates that anxiety is a consequence of the underlying schizophrenic disorder and also that the psychotic symptoms may not be a defense against anxiety.

Adult↗
PubMed1982

The time structure of depressive mood in schizophrenic patients.

This research focused on the depressive mood of 134 inpatients with a diagnosis of schizophrenia. All of the patients filled in a self-rating mood scale (Befindlichkeits-Skala by von Zerssen) every other day. The frequency of depressive mood and the intensity and dynamics of each period of depression were analysed with the aid of defined algorithms. Marked depression was found in more than half of the patients. Depression was seen predominantly at the beginning of hospitalization, and subsequent occurrences were not concentrated in any specific time periods. The results suggested that depression in schizophrenia is predominantly an experience or consequence of the underlying illness and that pharmacological factors are not of as great importance as has been thus far assumed in the literature.

Adolescent↗
PubMed1981

[The topology of the motor pathways in the internal capsule (author's transl)].

The topology of the motor pathways in the posterior peduncle of the internal capsule is discussed with regard to the literature and computer tomographic analysis of three patients with capsular lesions. Contradictory findings from morphologic, stereotactic, and computer tomographic investigations of the topology of the motor pathways in the posterior peduncle of the internal capsule have led to concepts which are mutually incompatible. It was first maintained that the motor pathways are located in the anterior third or two-thirds of the posterior peduncle and arranged somatotopically in the craniocaudal direction. A new interpretation which has received wide support from stereotactic investigations and studies of the pathologic anatomy of amyotrophic lateral sclerosis agrees on the somatotopic arrangement, but claims that the motor pathways are located rather in the posterior third of the posterior peduncle. By including ontogenetic factors and a critical relativistic consideration of the somatotopic arrangement of the posterior peduncle of the internal capsule in the analysis of the topology of the motor pathways in the posterior peduncle of the internal capsule, it can be demonstrated that the contradictions of published results and hypotheses are only apparent, thus making a uniform interpretation possible.

Amyotrophic Lateral Sclerosis↗
PubMed1981

[Neurotoxic side effects of cytostatic therapy (author's transl)].

As the advances in the field of cytostatic substances gain ground, more and more side effects and complications become manifest in the nervous system. Although the neurotoxic effects produced by different cytostatics present a different appearance and are partly of only sporadic or slight clinical importance, there is hardly a cytostatic which does not exercise a side effect on the nervous system. Definition of the side effects in the nervous system which are caused by cytostatics, is often difficult, because the neurotoxic syndromes are similar to disease patterns of different origin, especially those of the neoplastic and paraneoplastic type, both topically and clinico-phenomenologically. However, it is often of vital importance to arrive at the correct diagnosis well in time, because this will help the physician to decide whether the cytostatic should be discontinued or administered as before. For this reason, it may be necessary to employ, besides the neuropsychiatric examination, additional electrophysiological, CSF-diagnostic, CT and bioptic methods.

Antineoplastic Agents↗
PubMed1981

[The mitral valve prolapse syndrome as an aetiological factor in cardiophobia and juvenile insult (author's transl)].

The mitral valve prolapse may be an aetiological factor in anxiety neurosis and in transitory ischemias and cerebral insults in young adults. This syndrome must be considered in the differential diagnosis of cardiophobia. The symptoms of anxiety in the mitral valve prolapse syndrome are in no way different from the subjective symptoms in cardiophobia and in the other syndromes of free floating anxiety. The diagnosis of cardiophobia, including the wider scope covered by the syndrome of anxiety neurosis, should therefore include, besides other somatic examinations, echocardiography and long-term ECG examination. In the field of neurology, the prolapse of the mitral valve must be taken into consideration in all transitory ischaemic attacks and cerebral infarctions in relatively young patients.

Adult↗
PubMed1981

The course of depression for different types of schizophrenia.

During 197 courses of treatment for schizophrenia, depressive mood was evaluated every other day with a self-rating mood scale. The different patterns of depression identified in an earlier study could be correlated with the diagnostic subgroups of schizophrenia in which the patients were classified. Hebephrenic affect disturbance appeared as temporal discontinuity of depressive mood during the courses of treatment. Patients with a paranoid type of schizophrenia were the least depressed and had the fewest fluctuations of mood. Although patients with a schizoaffective type of schizophrenia exhibited characteristic changes between manic and depressive mood, their mood within a manic or depressive period was more stable than that of any other subgroup. The differences in depressive course are discussed in terms of their symptomatological and diagnostic significance.

Adolescent↗