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Biomedical subjects

F Stradner

Publications and source records attributed to F Stradner.

9 recordsLinked to original sources
PubMed1992

[Schmidt syndrome--a case report].

Pathologic organ specific autoimmune disease frequently affect endocrine glands and mostly lead to an insufficiency of the organs involved. Immunoendocrine diseases often occur in a polyglandular fashion and are consequently termed autoimmune polyglandular syndromes or immunoendocrinopathy syndromes. Among the different types one of the most frequent is known as Schmidt's syndrome or typus tyreosuprarenalis. Two case reports typical for this syndrome are described from a clinical point of view indicating also the respective diagnostics.

Addison Disease↗
PubMed1990

[Insulin-sulfonylurea combination therapy in secondary therapy failure with sulfonylurea compounds. Randomized study between evening and morning intermediary insulin administration using the Novo Pen semi-automatic insulin injector].

In 28 type II diabetics with secondary failure of sulfonylurea treatment, the efficacy and safety of combined therapy with insulin and glibenclamide were investigated. Patients were randomized in two groups and treated for 16 weeks either with insulin Novo Protaphan HM Penfill (100 IU/ml "bed time") and 10 mg of glibenclamide in the morning (group A), or with insulin Novo Actraphan HM Penfill 100 IU/ml in the morning combined with two 5 mg doses of glibenclamide at lunchtime and in the evening (group B). Subsequently a dropout trial of sulfonylurea was performed in half of the patients. Mean blood glucose levels were lowered in the whole group of patients from 13.5 +/- 1.8 mmol/l to 8.8 +/- 2.3 mmol/l after 8 weeks and 8.7 +/- 1.8 mmol/l after 16 weeks, and the HbAlc from 10.1 +/- 1.2% to 8.4 +/- 1.0% and 7.8 +/- 1.0% respectively. After a glibenclamide dropout period of one or two weeks in 14 of the patients, the mean blood glucose level rose significantly by 2.8 +/- 2.6 mmol/l. Only 2 patients did not show this increase. The mean insulin consumption was 13 +/- 3 IU after 8 weeks and 14 +/- 5 IU after 16 weeks respectively, and the incidence of hypoglycemia one in 12 weeks of treatment. The combination of glibenclamide and insulin (administered with the Novo Pen injector) is a safe and effective form of therapy in secondary failure of sulfonylurea, and is well accepted due to the mild start into insulin therapy.

Adult↗
PubMed1987

[Dupuytren's contracture as a concomitant disease in diabetes mellitus].

100 randomized diabetic patients were examined for the occurrence of Dupuytren's palmar contractions and for possible relations to the usual chronic diabetic complications, to metabolic control and to social and environmental factors. The incidence of the Dupuytren's palmar contraction in the total diabetic population was 42%. Contractions were most frequent on the tendons of the third and fourth fingers with a preponderance of the right side. The relative frequency of the Dupuytren's palmar contraction increased with age and the duration of diabetes mellitus. There were no relations to the chronic diabetic complications or the metabolic control. In conclusion Dupuytren's palmar contraction appears to be an age-dependent, but not specifical diabetic process, although it appears to be accelerated by diabetes mellitus.

Adult↗
PubMed1986

[Effect of celiprolol and metoprolol on serum lipids in patients with various forms of hyperlipoproteinemia].

In a single-blind prospective study, patients with hyperlipoproteinemias of the types II a, II b or IV were examined for changes of their serum lipid levels under the treatment with 300 mg celiprolol or 200 mg metoprolol, respectively, for a period of 4 weeks. Celiprolol led to a reduction of serum triglycerides, while the total cholesterol level remained practically unchanged; the HDL-cholesterol level rose from an average of 41.7 to 53.9 mg/dl (p less than or equal to 0.05). There was a slight increase of the LDL-cholesterol level and a significant decrease of the quotients between LDL- and HDL-cholesterol and between total cholesterol and HDL-cholesterol. Metoprolol caused a slight increase of the serum triglycerides, the total cholesterol level remained unchanged, while the HDL-cholesterol level slightly increased from 56.7 to 59.3 mg/dl. The level of LDL-cholesterol and the quotient between LDL-cholesterol and HDL-cholesterol decreased slightly. On the contrary, the quotient between total cholesterol and HDL-cholesterol remained practically unchanged. Celiprolol had a favourable influence on the serum lipid pattern, as far as the atherogenic risk is concerned.

Adrenergic beta-Antagonists↗
PubMed1984

[Diabetic osteoarthropathy].

The diabetic osteoarthropathy is an important diabetic complication. There is an obligatory connexion of the diabetic osteoarthropathy with the diabetic neuropathy. It seems to be essential for the diagnosis and treatment to separate the neuropathic and arthropathic lesions from angiopathic changes. It should be paid more attention to the diabetic osteoarthropathy in the treatment and training of diabetic patients suffering from diabetic neuropathy.

Adult↗
PubMed1983

[Experience in dietary counseling of diabetics with a new multifunctional learning aid].

The improvement of the effectivity of dietary lessons was investigated in a heterogenous diabetic patient material by using a newly developed multifunctional dietary learning-aid. There was a significantly improved dietary knowledge with respect to the quantitation of both carbohydrates and fat after a single lesson. Furthermore, the results justify the application of the dietary aid in elderly patients and in cases of long duration of the diabetes mellitus.

Diabetes Mellitus↗
PubMed1983

[Comparative studies between median blood sugar, hemoglobin A, triglycerides and C-peptide in normal-weight insulin and non-insulin dependent diabetics].

In our study the glycosylated haemoglobin was positively correlated with the mean bloodglucose concentration and the levels of serum triglycerides and proved to be a valuable parameter, which completes the hitherto existing possibilities of diabetes control. The difference of the levels of serum triglycerides and C-peptide between non-insulin-dependent and insulin-dependent diabetics, with the same quality of the levels of HbA 1 and mean bloodglucose, give us a help to decide, which therapeutic way would be the best in the introduction respectively correction of the treatment of the elderly diabetic patients.

Blood Glucose↗
PubMed1981

[Comparison of 100 micrograms TRH intravenously and 40 mg TRH orally in euthyroidism (author's transl)].

Euthyroid in-patients were investigated with 100 micrograms TRH given intravenously and with 40 mg TRH given orally in order to compare the sensitivity of intravenous and oral TRH-test. In all patients (age 15-91 years) maximal TSH-levels 180 min after 40 mg TRH are significantly (p less than 0.01) higher than maximal TSH-levels 30 min after 100 micrograms TRH. In patients under 50 years of age TSH-30 and TSH-180 are identical on average (6.42 +/- 0.29 microunits/ml vs. 6.53 +/- 0.54 microunits/ml/log x +/- SDlog). In patients older than 50 years TSH-30 is significantly lower (p less than 0.02) than in patients aging less than 50 years (2.11 +/- 0.88 microunits/ml vs. 6.42 +/- 0.29 microunits/ml). Both age-related groups demonstrate no significant difference (p greater than 0.2) in TSH-180 after 40 mg TRH (6.53 +/- 0.54 microunits/ml vs. 3.65 +/- 0.74 microunits/ml). 14 cases (34%) are low or non responders to 100 micrograms TRH intravenously, 8 (19.5%) only following 40 mg TRH orally. Patients with complete TSH-suppression (both iv. and oral TRH-test negative) show significant (p less than 0.05) higher ETR, T4 and fT4 than patients with partial TSH-suppression (iv. negative and oral TRH-test positive). The dose of 100 micrograms TRH does not increase the sensitivity of the test, the specificity is decreased in older patients, the dose of 100 micrograms TRH seems to be to low to yield reliable results. 40 mg TRH orally does not show any false positive findings, because TSH-stimulation is longer and more intensive. T3 increase three hours after orally TRH-application indicates an intact feedback mechanism.

Administration, Oral↗