[Clinical picture and diagnosis of primary hyperparathyroidism].
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Biomedical subjects
Publications and source records attributed to F Spelsberg.
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The medullary carcinoma of the thyroid plays a special role among the thyroid carcinomas due to his histiogenesis and endocrinologic behaviour. The symptoms like familiar occurrence, simultaneous pheochromocytoma, calcitonin-production, para-neoplastic syndroms with ACTH-production and the commonly associated diarrhea are discussed. The biological behavior of the tumor is presented reviewing the literature.
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Case report of a papillary thyroid gland carcinoma which was possibly induced by the irradiation of a parotid gland carcinoma.
A report is given on two cases of metastasizing ileum carcinoid in which the arteriography of the superior mesenteric artery and the hepatic artery lead to a correct diagnosis while no clear result could be obtained by conventional X-ray examinations (gastrointestinal passage and Irigoscopy of the colon). In the first case, the vascular alterations in the lower ileum, combined with numerous hyper-vascularized metastases in the liver allowed to diagnose the primary tumor and to determine its type. In the second case, a correct diagnosis could be made alone bacuse of the specific vascular alterations indicating the carcinoid which was growing by infiltration (vascular star, missing parenchymatous charge, belated venous drainage, in the tumor region). In one case, a second primary tumor whose growth was accompanied only by little infiltration could be early diagnosed. All diagnoses were confirmed by surgical and anatomicopathological findings. In order to ameliorate the prognosis, bad until now, by an earlier diagnosis, arteriography should be used whenever a (metastasizing) small intestine carcinoid is suspected.
From 1965 to 1973, 82 patients were operated on for mediastinal tumor. 42.7% of them were incidental radiological findings. Preoperatively, 66% of the mediastinal tumors were not morphologically confirmed. The lethality of the operation was 1.22%. Thymomas (29.3%) were the most frequent findings. 34.2% were malignant. While most patients with benign mediastinal tumors are cured by the operation, the 5 year survival rate for those with malignant tumors was 22%. Further special investigative procedures should only follow a guiding survey radiography in two planes if they can be expected to provide essential information on operability, operational tactics and approach.
A case is reported in which in vivo staining of insuloma cells was performed intraoperatively, using Toluidine Blue-O. The surgical problems of islet-cell tumors are discussed with special regard to the indication of in vivo staining as a definite method of intraoperative identification of these tumors.
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Between 1968 and 1973, 12 patients with a chronic afferent loop syndrome were treated at the University Surgical Hospital in Munich (6 from own hospital and 6 B II resected patients from external hospitals). 11 of them had to undergo reoperation (1 patient refused). X-ray and gastroscopy confirmed the diagnosis of chronic afferent loop syndrome type I in all 12 cases. The obstruction was caused by: adhesion and kinking of the loop (7 cases), too long and mobile loops (6 cases) incorrect anastomosis (3 cases), torsion and stenosis in the mesocolonic slit (2 cases), internal hernia (1 case). 8 patients showed good operative results, in 2 patients symptoms still persist; 1 patient died of sepsis postoperatively.
From 1954 to the end of 1973, 6432 patients were admitted to the Munich University Surgical Hospital for the treatment of malignant tumors of the digestive tract. 42 cases (0.66 percent) affected the small intestine, including the duodenum, but excepting tumors of the ileocecal region, peripapillar duodenal carcinoma, metastatic tumors of the small intestine and mesenteric tumors. The fate of all 42 patients with malignant tumors of the small intestine (6 carcinoids, 15 sarcomas and 21 carcinomas) was elucidated. 14 per cent of the malignant tumors were found in the duodenum, 27 percent in the jejunum and 59 per cent in the ileum.
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1. During thoracic duct drainage a significant decrease of serum beta- and gammaglobulins can be found. 2. The withdrawn lymphprotein can be sufficiently substituted by human serum albumin. 3. The number of small lymphocytes decreases significantly during thoracic duct drainage, while the number of large lymphocytes and lymphoid cells increases. 4. The drainage of thoracic duct in humans is a highly immuno-suppressive procedure without major risks.
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