Search PubMed⌕ Search

Biomedical subjects

F Soria

Publications and source records attributed to F Soria.

48 records · Page 3Linked to original sources
PubMed1990

[Differences by sex in the presentation and follow-up in the first year of acute myocardial infarct].

Three-hundred and nine patients, 242 males and 67 females diagnosed of myocardial infarction were studied during the acute phase and followed for a year to evaluate any differences. The corrected incidence was greater amongst males, 11.1 vs 3.6/10,000 inhabitants. The presenting age was significantly lower in males below 50 and greater in women above 70. Hypertension, hypercholesterolemia and sedentariness were more prevalent amongst women; smoking was more prevalent amongst males. Infarction presentation was typical in both sexes being significant a 5 hour delay in arriving to the hospital in female patients. On hospital admission Killip III-IV was significantly more frequent amongst women (17% vs 4.6%). Hospital mortality although it was higher in women this was not statistically significant (19.4% vs 14.4%). During follow up there was a better control of risk factors in the male patients. Heart failure and mortality were greater amongst women during the first three months (p less than 0.001). Mortality differences continued being statistically significant during the following three months. From the sixth month to the first year, mortality rates were similar. The study suggests that infarction prognosis is worse in females.

Adult↗
PubMed1989

Is there increased cardiovascular risk in essential hypertensive patients with abnormal kinetics of red blood cell sodium-lithium countertransport?

Na+ transport kinetics were studied in red blood cells (RBCs) from 50 essential hypertensive patients and 30 normotensive controls. Seven hypertensive patients were characterized by the following: (1) a maximal rate of Na+-Li+ countertransport higher than an upper normal limit of 525 mumol.litre cells-1.h-1; (2) an apparent dissociation constant for internal Na+ higher than an upper normal limit of 20.4 mmol.litre cells (in only five of the seven hypertensives); (3) no other kinetic abnormality in Na+,K+ pump, Na+,K+ cotransport or passive Na+ permeability. Clinically, hypertensives with abnormal countertransport were characterized by high serum low-density lipoprotein (LDL) cholesterol levels and the presence of electrocardiographic left ventricular hypertrophy (LVH). Conversely, mean values of these two clinical parameters were normal in the remaining hypertensive patients, independently of the presence of other abnormalities in Na+,K+ pump, Na+,K+ cotransport or passive Na+ permeability. In conclusion, the presence of abnormal Na+-Li+ countertransport kinetics in erythrocytes may be associated with an enhanced cardiovascular risk in hypertension.

Adolescent↗
PubMed1989

[The evaluation of the diagnostic usefulness of the clinical picture, electrocardiography and enzymes in the initial presentation of an acute myocardial infarct].

Medical data of 181 patients, affected by confirmed acute myocardial infarction, were reviewed to evaluate the initial clinical, electrographic and radiological data, and the first CPK test. Eleven patients went to the emergency department without chest pain (6.1%). The percentage of patients with oppressive chest pain was 73%, being of thoracic localization in 86.4%, 20%. Related to effort; 47.1% referred; and 92.9% of more than 30 mins. duration. 35.3% had normal blood pressure. Only 5 patients (2.8%) had normal EKG, the S-T segment elevation being the most frequent alteration (71.3%). 89.5% of patients had sinusal rhythms; 20.4% were bradycardic. 58.6% had normal levels of CPK at the first test. We concluded that EKG is the most important test in diagnosing acute myocardial infarction; it being very rarely normal. The clinical data are coadjuvant, while isolated initial CPK had not value.

Adult↗
PubMed1989

[Effect of nitrendipine in the treatment of mild or moderate essential arterial hypertension].

We studied 30 ambulatory patients with mild to moderate essential arterial hypertension, treated with the new calcium antagonist nitrendipine, during a follow-up period of six months and after a three week placebo period was completed. Nitrendipine initial dosage was 20 mg, given once daily in the morning. Normalization of blood pressure was achieved in every patient after three months of treatment, with a p less than 0.0001 since the first month and throughout the whole period. No concomitant changes in heart rate or vascular risk factors were observed. Eight patients needed their individual dosages to be doubled (40 mg) to achieve a complete normalization of their blood pressure values; four of them took the whole dosage once daily. We had to stop treatment in three patients because of significant worsening of previous symptoms. Although there was a 16.6% total incidence of secondary effects, the compliance was over 90%, which tells us about the relatively small importance of secondary effects observed. Flushing, which was present in five patients, was the most common secondary effect. Nitrendipine is an excellent antihypertensive drug, easy to use and responsible for a low number of disabling secondary effects, usually appearing in previously very symptomatic patients.

Drug Evaluation↗
PubMed1988

Syndrome of coronary artery spasm of normal coronary arteries. Clinical and angiographic features.

To define the clinical and angiographic features of the syndrome of spasm of angiographically normal coronary arteries, 77 patients with spasm and fixed angiographically normal coronary arteries, 77 patients with spasm and fixed coronary stenosis equal to or greater than 50% (group A) were compared with 35 patients with spasm and normal or minimally diseased coronary arteries (group B). Statistically significant differences between groups A and B were as follows: the incidence of rest angina (50.6% vs 85.7%; p less than 0.01) and mixed angina (32.5% vs 5.7%; p less than 0.01); the appearance of ST segment depression (53.3% vs 16%; p less than 0.01) and no electrocardiographic changes during stress test (35.6% vs 76%; p less than 0.01); and the tendency for arteriographically documented spasm to be focal (87.5% vs 71.4%; p less than 0.05) and to affect only one vessel (76.6% vs 57.1%; p less than 0.05). No differences were found between groups A and B in major coronary risk factors, history of previous myocardial infarction, electrocardiographic abnormalities at rest or during pain episodes, or arteries affected by spasm. Thus, angina appearing exclusively at rest is the main clinical feature of spasm of normal coronary arteries. The electrocardiogram, whether at rest or during pain episodes, has no value for predicting the existence of underlying coronary lesions, whereas stress testing does. Spasm of normal arteries tends to be more diffuse than that superimposed on organic lesions and to affect more than one artery, suggesting different mechanisms in the genesis of both types of spasm.

Adult↗
PubMedDate not supplied

Autoantibodies against P53 protein in patients with transitional cell carcinoma of the bladder.

Cellular accumulation and conformational changes of mutant p53 could act as immunogens for auto-antibodies (auto-Abs) generation when altered p53 from tumoral cells reaches the blood stream. Our main objective was to compare the presence and clinical implications of p53-antibodies in serum with the immunohistochemical (IHC) tissue overexpression of protein p53 in patients with transitional cell carcinoma of the bladder, evaluating their association with bladder cancer parameters and their prognostic value. The study comprised 59 patients with bladder cancer (group 1) and 15 healthy controls (group 2). Serum p53-Abs were measured by ELISA. Mutant p53 protein IHC overexpression was examined from paraffin embedded tissues using monoclonal DO-7 Ab. Serum p53-Abs were detected in 14/59 and IHC P53 was positive in 24/59 patients from group 1. All p53-Abs positive patients had IHC p53 positive tumors, but some patients with IHC positive immunoreactivity showed undetectable p53-Abs. None of the healthy controls had detectable p53-Abs. Titres of p53-Abs were associated with stage and grade. P53 overexpression was dependent on stage, grade, pattern of growth and focality. P53 Abs showed a significant prognostic value for disease free survival (p = 0.0059) and life expectancy (p < 0.0005) and for IHQ p53 for life expectancy (p = 0.0033). Patients with positive P53 Abs showed a higher probability for a shorter survival OR = 6.38 (1.77-22.99) than those who were positive for IHQ p53 OR = 4.00 (1.31-12.8) or those who were negative for p53 Abs and/or IHQ p53. The measurement of p53 Abs in serum appeared to be a simple determination which might reflect the p53 status and might help in the selection of those bladder cancer patients with a worse prognosis.

Adult↗
PubMedDate not supplied

[The regression of left ventricular hypertrophy following a short antihypertensive treatment].

With the objective of trying to prove the regression of ventricular mass in patients with essential hypertension, with and without left ventricular hypertrophy (LVH), we studied 42 patients of both sexes with echocardiography, measuring the left ventricular mass (LVM), the mean parietal thickness (MPT) and the relative parietal thickness (RPT), before and after one month of random treatment with atenolol, verapamil and xipamide, independently that the blood pressure control was or not satisfactory. We found significant reductions in the MPT with verapamil and atenolol (p = 0.006 and 0.036), although only verapamil induced a significant reduction of the LVM. The RPT did not shown any significant modification, although the tendency was opposed with xipamide and the other two groups, verapamil and atenolol. The factor Adequate control of the blood pressure, with any of the treatments, proved to be helpful in the favorable evolution of the regression. The degree of LVH before treatment does not appear to have any influence in the posterior evolution with the treatment.

Adult↗
PubMedDate not supplied

[Echocardiographic study following corrective surgery for transposition of the great arteries using a baffle].

Sixteen patients undergoing corrective surgery of transposition of the great arteries following Arcas' technique were studied by echocardiography. Mean age was 8.7 years, ranging from 2 to 25 years. The echocardiographic studies were performed between 6 months and 10 years after surgery (X: 5.6 years). Paradoxical movement of the interventricular septum, right ventricle dilatation, diastolic fluttering of the mitral valve and tricuspid incompetence are commonly recorded. Tricuspid insufficiency does not necessarily mean right ventricular disfunction in these patients. Due to the particular baffle shape, bidimensional echocardiographic recognition of superior cava vein obstruction is easy. In addition, the waves of cava veins showed a characteristic pattern with predominant diastolic wave, which is an argument against its obstruction. In conclusion, echo and Doppler studies are reliable means for an adequate follow-up of these patients.

Adolescent↗