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Biomedical subjects

F Smith

Publications and source records attributed to F Smith.

At least 163 records · Page 9Linked to original sources
PubMed1977

Myocardial infarction following coronary artery bypass: factors influencing its occurrence.

The authors have undertaken a prospective study on postoperative myocardial infarciton (PMI) following coronary artery bypass (CAB) grafting. PMI was diagnosed from electrocardiographic findings by the criteria of the American Heart Association. From Aug. 1, 1975 to Feb. 27, 1976, 198 patients (177 men, 21 women) underwent CAB. Their ages ranged from 31 to 71 years (mean, 49 yr). Of these patients, 18 (9%) sustained a PMI. A number of factors were analyzed to determine their influence on the occurrence rate of PMI. Preoperative factors wuch as the New York Heart Association classification, measurement of left ventricular function and evaluation of the severity of coronary artery disease were not helpful in predicting a predisposition to PMI. Endarterectomy was the only operative intervention associated with a higher inicidence of PMI (18%). Other factors such as the interval of cardiac anoxia and cardiopulmonary bypass and the number of vessels grafted did not seem to be associated with PMI. Low blood flow (less than 40 ml/min) through the graft could be correlated with the area of infarction in only 5 of 18 patients. Among the operated patients, postoperative ventricular arrhythmia was much more common in patients with PMI. The hospital mortality in this group was 11% (two patients).

Adult↗
PubMed1976

Evaluation of sclerosing cholangitis by endoscopic retrograde cholangiopancreatography.

Endoscopic retrograde cholangiopancreatography contributed considerably to diagnosis or subsequent management of two cases of sclerosing cholangitis, In the first patient, sequential studies helped to determine the timing and nature of the surgical intervention that was used. In the second patient, the diagnosis was suggested by ERCP, which led to surgical exploration and biopsy of the common bile duct to confirm the diagnosis. The quality of the films obtained in both patients was excellent. We suggest that ERCP is a relatively noninvasive and accurate means of follow-up in cases of sclerosing cholangitis.

Adult↗
PubMed1975

The type II epithelial cells of the lung. II. Chemical composition and phospholipid synthesis.

A method to isolate 93 per cent viable (trypan blue), 95 plus or minus 2 per cent pure type II alveolar epithelial cells (Kikkawa, Y., and Yoneda, K. Lab. Invest. 30: 76, 1974) was slightly modified and was used to isolate type II cells of similar purity and viability from New Zealand White male rabbits. The modification as described in this report now permits the regular harvest of 20 to 30 times 10-6 cells from a rabbit weighing 2 to 4 kg. Lipid composition of type II cell pools thus collected was compared with that of macrophages collected by alveolar washing. Per milligram of protein, type II cells contained 19 mug. of lipid phosphorus, compared with 11 mug. for macrophages. Per 1 times 10-8 cells, type II cells contained 110 mug. of lipid phosphorus compared with 155 mug. for macrophages; Phosphatidylcholine comprised 48 per cent of total phospholipid in type II cells and 34 per cent in macrophages. Forty-nine per cent of the phosphatidylcholine in type II cells was disaturated, compared with 29 per cent in macrophages. These data indicate that, per cell, type II cells contain almost twice as much disaturated phosphatidycholine as do alveolar macrophages. Radiolabeled precursor studies suggest that isolated type II cells synthesize disaturated lecithin predominantly through the cytidine diphosphocholine pathway. -14C-choline incorporation into disaturated lecithin was 3 times as active in type II cells as in macrophages. No evidence was found for a significant contribution to synthesis of disaturated lecithin by the transmethylation pathway in isolated type II cell preparations. These results offer the most direct evidence to date of the significant role of the type II alveolar epithelial cell in the synthesis of disaturated lecithin, a major constituent of pulmonary surfactant.

Animals↗