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Biomedical subjects

F Skrabal

Publications and source records attributed to F Skrabal.

95 records · Page 6Linked to original sources
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Realtime measurement of stroke volume--an adaptive monitoring system and its application.

A variety of monitoring systems is available for special fields of clinical application and scientific research. Whenever requirements change data acquisition and handling of signal analysis have to be adapted or even completely new structured, especially in real-time applications. This can be a time consuming procedure. In order to be able to focus on the development of algorithms without taking care how data are acquired a monitoring system has been developed which can be adjusted in terms of signal acquisition, analysis and user handling. New algorithms can be added and polygraphical presentation of results can be adjusted for special clinical requirements. As a specific application the online and real time calculation left ventricular ejection time (LVEJT), stroke volume (SV), cardiac output (CO), mean blood pressure and total peripheral resistance (TPRI) is presented.

Algorithms↗
PubMedDate not supplied

Salt sensitivity in humans is linked to enhanced sympathetic responsiveness and to enhanced proximal tubular reabsorption.

If high sodium intake is involved in the pathogenesis of essential hypertension, the effects of changing the sodium intake should be demonstrable in the susceptible part of the normotensive population. Therefore, we have investigated the effects of moderate salt restriction in 52 young normotensive subjects with and without a family history of hypertension; 22 (42%) responded to moderate salt restriction (200 to 50 mmol/day) over 2 weeks, with a significant fall in blood pressure shown by continuous automatic blood pressure recordings. Accordingly, these subjects were classified as salt-sensitive, and the remainder as salt-resistant. Compared to salt-resistant subjects, salt-sensitive subjects showed a 2.5-fold higher incidence of a positive family history of hypertension (p less than 0.01), and a significantly higher blood pressure and lower salivary sodium concentration during the usual high sodium diet. Although there were no differences in Na,K-ATPase activity and in Na-K cotransport of erythrocytes, the pressor response to infused norepinephrine in salt-sensitive subjects was double that of salt-resistant subjects independent of the diet and this was linked to indirect evidence for enhanced proximal tubular sodium reabsorption. On the usual high sodium diet, 40% of the normal population may be salt-sensitive and prone to develop hypertension. Hypersensitivity to catecholamines (genetically determined?) may be the cause of salt sensitivity. A low sodium concentration in saliva deserves further study as a simple screening test to identify salt-sensitive subjects.

Adult↗