[Surgical treatment of fractures of the tibial plateau].
Explore the source record for details and available documents.
Adult↗
Biomedical subjects
F Serra
Publications and source records attributed to F Serra.
Arbovirus investigations in southern Italy (Calabria).
Explore the source record for details and available documents.
Animals↗
[Oxazepam poisoning in a 2-year-old child].
Explore the source record for details and available documents.
Ataxia↗
Atomic force microscope characterization of a resonating nanocantilever.
An atomic force microscope (AFM) is used as a nanometer-scale resolution tool for the characterization of the electromechanical behaviour of a resonant cantilever-based mass sensor. The cantilever is actuated electrostatically by applying DC and AC voltages from a driver electrode placed closely parallel to the cantilever. In order to minimize the interaction between AFM probe and the resonating transducer cantilever, the AFM is operated in a dynamic non-contact mode, using oscillation amplitudes corresponding to a low force regime. The dependence of the static cantilever deflection on DC voltage and of the oscillation amplitude on the frequency of the AC voltage is measured by this technique and the results are fitted by a simple non-linear electromechanical model.
Journal Article↗
Diamond-Gardner syndrome: a case report.
We present a 13-year-old girl who came to our attention for an erythematous bruised lesion which appeared spontaneously without any apparent coagulopathy. The history, histology, and positive "skin-test," carried out by subcutaneously injecting autologous erythrocytes obtained from heparinized blood, confirmed the suspected diagnosis of Diamond-Gardner syndrome. No alterations of blood vessel walls or thromboses were found. Evaluation of hemocoagulative parameters revealed an increased factor VIII level and reduced platelet aggregation after stimulation by adenosine diphosphate (ADP.)
Adolescent↗
Specific and non-specific parameters of the host defence system in patients with superficial fungal infections.
Some measures of systemic host defences, i.e. white cell counts, lymphocyte subsets, delayed-type hypersensitivity and polymorphonuclear leucocyte functions, were evaluated in 42 patients suffering from cutaneous superficial mycoses and in 35 healthy volunteers. Patients were divided according to the extent of their lesions into two groups: group A (30 patients) with skin involvement > or = 30% and group B (12 patients) with skin involvement < or = 1%. No significant abnormalities in systemic defence mechanisms were observed in group B patients, whereas multiple alterations of polymorphonuclear phagocyte activities, i.e. chemotaxis, phagocytosis, mitogen-induced superoxide anion production, were observed in patients with extensive lesions. The values of these phagocytic functions remained significantly reduced (P < 0.01) in these patients after recovery and during a 6-month follow-up period.
Adolescent↗
Pityriasis versicolor in a newborn.
Pityriasis versicolor is a superficial mycosis that rarely afflicts children. We present a case in a 2-month-old male baby in good health, with hyper- and hypopigmented macules located in the cervical region and on the scalp, face and chest. Moreover, we report our record of cases in infancy and the predisposing factors.
Age Factors↗
Tissue composition in persistent dietary obesity after early and adulthood overfeeding in the rat.
The objective of this study was to assess the effects of prolonged cafeteria-diet feeding on tissue composition in adult rats comparing those that had been overfed in early life and then in adulthood with a group that was only overfed in adulthood, and to determine whether any alterations were related to the high energy diet per se or to obesity. In addition to following the body weight changes in detail, tissue masses and composition were determined at selected points of this long term dietary experiment. The marked changes in body weight and tissue composition of cafeteria-fed obese rats were sustained for at least 84 days after returning to the standard diet, and the obesity was exaggerated if these animals were pre-exposed to the palatable diet in early life. Three patterns of tissue composition in response to cafeteria feeding could be discerned: Liver and brown adipose tissue developed cell hypertrophy without apparent hyperplasia. In contrast, the retroperitoneal white adipose depot developed hyperplasia whereas the intestine and kidneys were not associated with marked changes in lipid composition. These adaptations were not recovered to control levels by prolonged standard diet feeding. Previous obesity influenced the adaptations in adipose tissue during the subsequent return to standard diet feeding, and differences between cafeteria-induced obese animals became more apparent when the cafeteria diet was removed. These results indicated the important effects of early dietary experience in subsequent responses to overfeeding.
Adipose Tissue↗
Erythrocyte uptake kinetics and cell to plasma gradients of leucine and phenylalanine in fed and fasted rats.
The kinetic parameters of the L-phenylalanine and L-leucine uptake by isolated erythrocytes in fed and 24 hour starved rats have been determined. In addition, the in vivo compartmentation between blood cells and plasma of the above amino acids in arterial and venous blood vessels has also been studied under the above physiological situations. Both the L-phenylalanine and L-leucine uptake by erythrocytes was saturable and non concentrative. Starvation increased the Km value for the leucine uptake and did not significantly affect that of phenylalanine uptake. The in vivo blood cell/plasma (C/P) concentration ratio of both amino acids was higher than the unit. The starvation-induced changes in the relative distribution of these amino acids between the blood cell and the plasma compartments were significant for the phenylalanine in the aortic artery but not in venous blood. The transport system capabilities measured in vitro can not account for the maintenance of both the leucine and phenylalanine gradient between blood cells and plasma, and the starvation-induced changes in the blood amino acids compartmentation are not directly related entirely to the transport system capabilities.
Animals↗
[Determination of residues of chlorinated and phosphorated pesticides on the fruit of Pesaro province (author's transl)].
The residues of pesticides chlorinated and phosphorated on the fruit of Pesaro province at the moment of its immission on the market has been determined. No pesticides has found to have a residue near to toxicity values, but sometimes more than one pesticide has been found on the same sample. This fact, also if not alarming, must be attentively considered in order to promote a better information campaign and therefore a more rational use of those substances.
Fruit↗
[Evaluation of the locomotor system during pediatric health examinations and elements of kinesitherapy].
The pediatrician, being a primary health care physician, has the task of bringing the small patient and his parents to the resolution of all those problems which are erroneously referred to a subspecialist. With this in mind, the authors believe that even common orthopedic problems must be evaluated by the pediatrician. He would decide if and when to refer the child to an orthopedic specialist. Certain problems such as congenital hip dysplasia or scoliosis require specific treatment, whereas others (tibial bowing, genu varum-valgum, flatfoot, metatarsus varus) resolve themselves over time. The authors therefore emphasize the role of the pediatrician in preventing any iatrogenic pathology due to inappropriate treatment.
Child↗
[Psychiatric problems in general medicine and internist-psychiatrist collaboration for their treatment].
Explore the source record for details and available documents.
Humans↗
Foot alterations in the hemodialyzed patient.
On the basis of their experience, the authors refer to complications observable at the foot level in chronic uremic patients in long-term hemodialytic treatment. These complications, termed renal osteodystrophy, are attributed to alterations in the phosphocalcium metabolism and to hyperparathyroidism. From an anatomopathologic viewpoint, they are characterized by alteration in bone tissue (osteomalacia and/or fibrous osteitis) and by soft tissue alterations. Alterations in the foot are the same as those observed in other osteoarticular regions. They consist of bone subperiosteal reabsorption of the phalanges, vascular calcifications, articular and para-articular calcifications, spontaneous disinsertion of the Achilles tendon and peripheral canalicular neuropathies specifically represented by the tarsal tunnel syndrome. Another complication of this pathology is represented by "Calciphylaxis," characterized by calcifications of the middle tunica of arteries and small arteries, by ulcerations and tissue necrosis at the foot level.
Chronic Kidney Disease-Mineral and Bone Disorder↗
Charcot's foot.
Diabetic osteoarthropathy is a chronic progressive arthropathy involving the bones and joints being constantly associated to somatic and autonomic peripheral neuropathy. The pathogenesis is related to sensory and motor neuropathy with morphologic foot alterations, relaxation and abnormal position on walking till complete collapse of the foot shown by the depressed longitudinal medial arch. Bone reabsorption due to osteoclasis and increased blood flow until osteomalacia appears, is characteristic of this arthropathy. The clinical features vary according to the location and severity of articular impairment and the stage of identification. The metatarsophalangeal or tarsometatarsal joint may be involved. The typical manifestation of Charcot's foot is plantar ulcer of variable location according to the weight-bearing area. Treatment tends to reduce the abnormal stress predisposing to ulceration with tailored footwear and orthoses.
Adult↗
The foot clinic. Multidisciplinary management of the patient with diabetic foot.
Treatment of a complex disease as the diabetic foot requires a multidisciplinary management with the close collaboration of a team for care. The most important members of the team are the diabetologist as coordinator, the vascular surgeon, the orthopedist, the radiologist, the orthopedic technician, the podiatrist and the nurse specialist. The care based on this arrangement should be carried out in dedicated rooms and times to exploit at best the organizational potential in the patient's interest, implemented in the foot clinic.
Diabetic Foot↗
[Correlation between HIV-inhibiting drug activity in human macrophages and clinical outcome].
PURPOSE: To assess the comparative efficacy of drugs inhibitors of human immunodeficiency virus (HIV) in human macrophages and lymphocytes, and to correlate the results with the clinical outcome. MATERIALS AND METHODS: Human primary macrophages and lymphocytes were infected with HIV in the presence of the following HIV inhibitors, all currently in clinical use: zidovudine, stavudine, zalcitabine, didanosine, lamivudine, PMEA, PMPA (all inhibitors of HIV reverse transcriptase), saquinavir and U-75875 (inhibitors of HIV protease). RESULTS: All reverse transcriptase inhibitors tested showed a markedly higher antiviral activity in macrophages than in lymphocytes. Also protease inhibitors have a substantial anti-HIV activity in macrophages, yet their efficacy is markedly diminished if the drugs are added to macrophage culture after HIV, that is when the virus has established a chronical infection. Under these experimental conditions, however, only protease inhibitors among all HIV-inhibitors in clinical use are able to decrease virus replication in chronically-infected macrophages. CONCLUSIONS: The results have strong clinical implications, due to the important role of macrophages in the pathogenesis of HIV infection. Macrophages are the major source of HIV at extralymphoid tissue levels, particularly in the central nervous system, where the blood-brain barrier strongly limits the penetration of antiviral drugs. For these reasons, only drugs, like stavudine and zidovudine, provided with good anti-HIV activity in macrophages, and reasonable barrier penetration have substantial chances to be effective in the central nervous system, and thus affect virus replication in a sanctuary where HIV hides and replicates out of the control of the immune system.
Acquired Immunodeficiency Syndrome↗