Biomedical subjects
Publications and source records attributed to F Serban.
PURPOSE: To comparatively evaluate the biochemical profile in normal human lenses with capsule and in stages of age related opaque lenses without capsule. MATERIALS AND METHODS: The study included 3 groups of lenses with transparent structure, mature and incipient cataract. RESULTS: The results were for 25 biochemical investigations. CONCLUSIONS: Multiple biochemical mechanisms contribute to the progressive loss of transparency of the lens.
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The professional poisoning with acrylonitrile of some subjects induced a significant decrease of reduced glutathione (81.30%), redox ratio reduced glutathione/oxidized glutathione (90.74%) and "Benzi-redox index" (55.84%) but an increase of oxidized glutathione level (112.6%) as compared to normal controls (100%). This proves the occurrence, in time, of the cellular oxidative stress and/or were obtained.
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7,917 pupils in schools, between 10-19 years old, of both sexes, were investigated within an epidemiologic screening, performed in the school milieu, for detecting the prevalence of some risk factors (RF) and of the AT modifications with a view to work out the programmes for the essential arterial hypertension (EAHT) primary prevention. 84.4% of all the pupils in the Vth--VIIIth forms and 93.9 pupils in the IXth--XIIth forms were included in the screening. 422 cases of labile arterial hypertension (LAHT) (5.1%) and 457 of benign arterial hypertension (BATH) (54%) were found. In the children with normal arterial hypertension (NAHT) the following were recorded: 46.5% increases only of the diastolic tension: 44.0% of the systolic-diastolic and 7.1% of the systolic tension respectively. Although present, the differences between the LAHT and BAHT prevalence in the gymnasiums (4.3% and 5.4%) and lyceums (5.5% and 6.4%) are not significant and might be functions of: age, sex, psychomotor development, structure of the respective collectivities, the momentary psychoemotional reactions, lability of the blood pressure, specific to the childhood, several screening difficulties etc. The observations made on the prevalence of the growth of the AT values were correlated with the occurrence at some significant levels of the RF, suggesting the measures to be taken for the steady improvement of the primary and secondary prophylaxis of EAHT in schools.
Based on an epidemiological screening of 6411 pupils from 7 schools of different types, the frequency and intensity of the association of 8 risk factors for essential hypertension in a series with increased blood pressure values and in a normotensive one was compared. The frequency of the various studied risk factors was significant especially in the pupils with increased blood pressure values. The average number of risk factors in the two series was unsignificant. The intensity of 2, 3 or 4 risk factors different associations was more marked in the pupils with increased blood pressure values than in the controls. Some risk factors proved to be more frequently involved in multifactorial associations. The importance of such studies for the elaboration of prevention programmes in underlined.