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Biomedical subjects

F Seow-Choen

Publications and source records attributed to F Seow-Choen.

At least 127 records · Page 7Linked to original sources
PubMed1996

Prospective randomized study of sulindac versus calcium and calciferol for upper gastrointestinal polyps in familial adenomatous polyposis.

Eighteen patients with familial adenomatous polyposis (FAP) who had previously undergone colectomy but had upper gastrointestinal polyps were studied in a double-blind randomized crossover trial comparing sulindac with calcium and calciferol. Sulindac produced a reduction in the crypt proliferation index in the gastric epithelium of patients but did not significantly affect duodenal mucosa. Calcium with calciferol did not have any effects on crypt proliferation index in patients with FAP.

Adenomatous Polyposis Coli↗
PubMed1996

The "inadequate doughnut" technique for stapling in rigid rectums.

PURPOSE: A technique to achieve sound anastomosis of a stiff irradiated rectum is described. METHOD: After application of the pursestring, manipulation of the rectal stump creates an inadequate doughnut anteriorly after firing the circular stapler, which is conveniently repaired manually. RESULTS: A sound anastomosis is achieved. CONCLUSION: This technique is efficient and reliable for creating a sound anastomosis in the rigid rectum.

Anastomosis, Surgical↗
PubMed1996

Prospective randomized trial of drainage alone vs. drainage and fistulotomy for acute perianal abscesses with proven internal opening.

PURPOSE: Incision and drainage (I & D) with concurrent or delayed fistulotomy is the usual treatment for abscess-fistula with a demonstrated internal opening. We compared incision and drainage alone vs. with concurrent fistulotomy for perianal abscesses with a demonstrated internal opening. METHODS: Consecutive patients with acute perianal abscesses and a demonstrated internal opening were prospectively randomized into either the I & D group or drainage with concurrent fistulotomy group. They were followed up at one month, three months, and one year. RESULTS: The I & D group had 21 patients, and the fistulotomy group had 24 patients. Thirteen patients had low intersphincteric abscess-fistula, and seven had low transsphincteric fistulas in the I & D group. The fistulotomy group had 9 intersphincteric abscess-fistula compared with 14 low transsphincteric ones. Median duration of surgery, hospital stay, and continence at final follow-up were the same in the two groups. Three had recurrent abscess-fistula in the I & D group compared with none in the fistulotomy group (P = 0.09). CONCLUSION: I & D alone for acute anal abscess-fistula with demonstrated internal opening showed a tendency to recurrence that did not reach a statistically significant difference compared with concurrent fistulotomy. I & D, therefore, puts only a few patients at risk for recurrence.

Abscess↗
PubMed1996

Comparison between segmental left and extended right colectomies for obstructing left-sided colonic carcinomas.

PURPOSE: This study was designed to compare complications and functions following either radical extended right colectomy without colonic decompression or radical segmental left colectomy with intraoperative decompression for obstructed left-sided colonic carcinomas. METHODS: One hundred three patients with obstructed left-sided colonic carcinoma undergoing primary resection and anastomoses were studied. RESULTS: There were 57 males and 46 females with a median age of 65 (range, 24-98) years and who had a median follow-up of 31 (range, 2-59) months. There were no leaks or intra-abdominal sepsis in the extended right colectomy group (44 patients) compared with one anastomosis leak in the segmental left colectomy (59 patients) group. Median hospital stay was 14 days in both groups, with a range of 8 to 36 days in the segmental left colectomy group and 7 to 44 days in those with extended right resection. One month after surgery, the patients who underwent segmental left colectomy had a median bowel movement of 3 (range, 1-6) per 24 hours compared with those with extended right colectomies who had a median of 5 (2-11) bowel movements per 24 hours. Bowel frequency decreased to four or less episodes per 24 hours in all patients in both groups at six months. CONCLUSION: There was no significant difference between bowel function or complications between the two groups.

Adult↗
PubMed1996

Surgery for inflammatory bowel disease in Singapore.

Inflammatory bowel disease is uncommon in Asians and reports of surgery in these populations are rare. Eighty-two patients with inflammatory bowel disease were seen in the Department of Colorectal Surgery over a five-year period (1989-1994). Twenty-three patients underwent surgery for their disease. There were 12 males and 11 females with 16 Chinese, 4 Indians and 3 Malays. Twelve had Crohn's disease and 11, ulcerative colitis. The majority of patients with Crohn's disease had emergency surgery for bleeding, perforation, abdominal masses and intestinal fistulae. Fifty percent of these had the diagnosis made intraoperatively or post-operatively. Surgery for ulcerative colitis was indicated because of multiple relapses, non-response to medical treatment, side effects of therapy or malignant change. The median age at surgery of patients with Crohn's disease and ulcerative colitis was 39 years (range 24-84) and 40 (range 18-60) respectively. The median follow-up was 22.4 months (range 9-50). The results of surgical therapy in these patients show that surgery when indicated can be done with minimum morbidity and mortality.

Adult↗
PubMed1995

Prospective randomized study of radical versus four piles haemorrhoidectomy for symptomatic large circumferential prolapsed piles.

Twenty-eight patients (14 men, 14 women) with circumferential prolapsed piles were prospectively randomized to undergo either modified radical haemorrhoidectomy (group 1; 14 patients) or four piles haemorrhoidectomy (group 2; 14). The median duration of surgery was 30 and 10 min respectively in groups 1 and 2. After operation all patients in group 1 were continent compared with 12 of 14 in group 2. Two patients in group 2 developed an anal stricture requiring manual dilatation. Five patients in group 1 had wound dehiscence requiring secondary suture; three of these developed an anal stricture: two needed anal dilatation and one required anoplasty. Two patients in group 1 had residual anal skin tags, compared with nine in group 2. Two patients in group 2 had symptomatic residual piles, whereas none in group 1 had this problem. At 6 months, six patients in group 2 considered the results to be excellent, seven acceptable and one was disappointed. In group 1 two considered the operation to be excellent, ten acceptable and two were disappointed.

Adult↗
PubMed1995

Haemorrhoidectomy and disordered rectal and anal physiology in patients with prolapsed haemorrhoids.

The effect of haemorrhoidectomy on rectal and anal physiological abnormalities was studied in 24 consecutive patients (12 men and 12 women of mean (s.e.m.) age 39.1 (2.4) years) and compared with results in 13 sex- and age-matched controls. Before operation those with haemorrhoids had significantly higher resting anal pressures (P < 0.005), lower rectal compliance (P < 0.05) and more perineal descent (P < 0.05). Following haemorrhoidectomy there were significant decreases in the maximum resting (P < 0.05) and maximum squeeze anal (P < 0.001) pressures to within normal values 3 months after operation. Rectal compliance also increased significantly (P < 0.05), to that of normal controls. The abnormalities found in patients with prolapsed piles reverted to the normal range within 3 months of haemorrhoidectomy. These physiological changes are therefore more likely to be an effect, rather than the cause, of enlarged anal cushions.

Adult↗
PubMed1995

Prospective randomized trial comparing J colonic pouch-anal anastomosis and straight coloanal reconstruction.

Twenty patients (13 men) with low rectal cancer, median (range) age 64.5 (38-83) years were prospectively randomized to undergo ultra-low anterior resection with a J colonic pouch-anal anastomosis (median (range) distance of anastomosis from the anal verge 3 (1-4) cm). Another 20 patients (15 men), median (range) age 62.5 (44-86) years) with low rectal cancer were randomized to a straight coloanal anastomosis (median (range) distance of anastomosis from the anal verge 3.25 (2-5) cm). There were no significant differences in operative time or complications between the two groups. There was significantly better postoperative anal function in patients who underwent pouch-anal anastomosis at 1, 6 and 12 months after ileostomy closure. At 12 months all patients (19 of 19) with a pouch reconstruction had regained normal continence compared with 14 of 20 of those who had a straight coloanal anastomosis. No patient complained of severe constipation requiring enema or intubation to evacuate.

Adenocarcinoma↗
PubMed1995

Prospective randomized controlled trial of a micronized flavonidic fraction to reduce bleeding after haemorrhoidectomy.

A prospective randomized controlled trial was carried out on the effects of Daflon 500 mg (a micronized flavonidic fraction containing diosmin 450 mg and hesperidin 50 mg) on bleeding after haemorrhoidectomy. In all, 228 consecutive patients with prolapsed irreducible piles were recruited. Elective haemorrhoidectomy was performed with a standardized diathermy excision method. Some 114 patients were randomized to receive Daflon 500 mg for 1 week after operation (group 1), and there were 114 controls (group 2). Postoperative analgesia and laxative prescription as well as hospital stay were otherwise the same. One patient (0.9 per cent) from group 1 and seven (6.1 per cent) from group 2 had postoperative bleeding (P = 0.03). All bleeding occurred from 6 to 15 days after haemorrhoidectomy. There were no side-effects from the use of Daflon 500 mg. The risk of secondary bleeding from haemorrhoidectomy is reduced with postoperative Daflon.

Adult↗
PubMed1995

Non surgical management of colonoscopic bowel perforation.

Five patients (four males, and one female, median age of 60 years) with colonoscopy-related bowel perforations were managed between January 1993 and June 1994. One patient had a difficult colonoscopy whereas four patients had polypectomies or biopsies. Abdominal pain was the main presenting symptom at a median of 3 h (range 2 to 12 h) following colonoscopy. Four patients demonstrated free pneumoperitoneum whilst one showed a pelvic abscess. Following non-surgical management, abdominal signs diminished after 24 to 48 h and disappeared by the fifth day in all patients. All patients were discharged well at day seven (range 5 to 9 days) and have remained well at 12 months of follow-up (range 3 to 18 months).

Acute Disease↗
PubMed1995

Submucosal adrenaline injection for posthemorrhoidectomy hemorrhage.

PURPOSE: A technique found effective in stopping active posthemorrhoidectomy bleeding, outside the operating room, is described. METHOD: After resuscitation and sedation, a proctoscope was inserted to identify the bleeding point. 1 to 2 ml of 1/10,000 adrenaline was injected submucosally. RESULTS: This technique was totally successful in 12 of 12 treated patients. CONCLUSION: Submucosal adrenaline injection is a simple and readily accessible technique for managing posthemorrhoidectomy bleeding.

Epinephrine↗
PubMed1995

Lateral sphincterotomy compared with anal advancement flap for chronic anal fissure.

PURPOSE: This study was designed to assess differences between lateral internal anal sphincterotomy and anal advancement flap for chronic anal fissure. METHODS: Forty patients with chronic anal fissure were prospectively studied. Patients randomized to the sphincterotomy group (n = 20; median age, 34 (range, 16-61) years) underwent lateral internal anal sphincterotomy. Patients randomized to the flap group (n = 20; median age, 32 (range, 20-44) years) had an anal advancement flap. RESULTS: All fissures in the sphincterotomy group healed following surgery compared with three patients that failed to heal in the flap group (P = 0.12). No patient in either group was incontinent to any degree following surgery. Patient satisfaction with surgery was similar in both groups. CONCLUSION: Anal advancement flap is an alternative to lateral sphincterotomy for chronic anal fissure.

Adolescent↗
PubMed1995

Anal stricture following haemorrhoidectomy: early diagnosis and treatment.

Anal stricture is an uncommon but well recognized complication following haemorrhoidectomy. Twenty-seven (3.8%) out of 704 (500 elective and 204 emergency) cases of haemorrhoidectomy performed at the Singapore General Hospital over a 24 month period had clinical evidence of anal stricture post-haemorrhoidectomy. Of the 27 cases, 15 had haemorrhoidectomy as an elective procedure while 12 had it performed as an emergency procedure (chi 2 = 3.26, 1 d.f., P > 0.05, not significant). The mean interval between surgery and presentation of anal stricture was 6 weeks (range 3-12 weeks). Eighteen of the patients were managed by anal dilatation in the outpatient clinic combined with bulk laxatives and a local anaesthetic agent. The other nine patients required a minor surgical procedure comprising either a lateral internal sphincterotomy (five) or an anoplasty (four) procedure. All patients were well, following treatment. None of these patients developed a recurrent stricture at follow up 3 months after treatment. It was concluded that although anal stricture following haemorrhoidectomy is rare, it should be detected and treated early in order to avoid pain and suffering, and treatment is usually successful.

Adolescent↗
PubMed1995

Bladder involvement in patients with colorectal carcinoma.

Twenty-seven patients underwent concomitant partial cystectomies out of a total of 542 patients with colorectal carcinoma operated on between October 1989 to December 1991. There were 19 males and 8 females with a median age of 63.7 years (range 44-80). The patients were followed up for a median of 40.2 months (range 27-75 months). Histological invasion into the bladder was found in only 26% of the tumours. Eighty-five percent of the patients with carcinomatous invasion had preoperative urological symptoms whilst only 20% of those with inflammatory adhesions had urological symptoms. Four percent of the patient were Dukes' A, 50% Dukes' B, 42% Dukes' C and 4% Dukes' D. Twenty (74%) patients are alive without evidence of local or distant metastasis. One has local recurrence and another, distant metastasis. Five patients have died. The prognosis of patients with colorectal cancer and bladder involvement appears to be similar to those without bladder involvement provided clear margins are obtained.

Adult↗