Biomedical subjects

F Sefrna

Publications and source records attributed to F Sefrna.

At least 37 records · Page 2Linked to original sources

PubMed1991

Serum cholesterol increase in a middle-aged male industrial population during ten years (1976-1986) and general food consumption changes in Czechoslovakia.

The authors evaluate the coronary risk factor changes in middle-aged men from the point of view of changed nutritional habits of the whole population (yearly per capita consumption of different food). They compared 3,754 men aged 40-50 years when screened in 1976-77 (Skoda I Study) and 568 men aged 40-50 years when screened in 1986-88 (Skoda II Study). During the 10-year period, a significant decrease of smoking habits was observed, hypertension prevalence remained unchanged and hypercholesterolaemia prevalence increased significantly. The estimated yearly per capita consumption of meat and fat remained unchanged in the years 1975-1985, however, the structure of consumption revealed a gradual change towards food containing high amounts of animal fat. Education efforts during the 10-year period (1976-1986) led to a decrease in smoking habits in middle-aged men leaving hypertension control unchanged. The observed increase of cholesterol levels may be attributed to inappropriate nutritional habits gradually worsening in the whole population probably due to a socio-economic depression.

Adult↗

PubMed1990

[Improvement in the detection and control of hypertension in the industrial population of the Skoda Plzen factory 1976-1986].

The authors investigated the effect of the ten-year intervention programme on the standard of detection, control and effectiveness of treatment of arterial hypertension in an industrial population. The prevalence of hypertension did not change during the investigation period (about 24%). In group B (1986) a decline of the blood pressure was recorded in all age groups on average by 10/0 mmHg (1.3/0 kPa) in men and by 15/9 mmHg (2/1.2 kPa) in women. In men detection improved and the ratio of treated hypertonics increased (p less than 0.05); in women the trend of improvement was not significant. The number of untreated subjects with hypertension did not change in the course of 10 years (15-16% of all hypertensive subjects). 50% hypertensive men and women were treated effectively in group A and 59% men with high blood pressure in group B; the ratio of effectively treated hypertonic women in group B did not change. There was no difference in the level of control of hypertension between men and women in either group. The differences in the prevalence and treatment of severe hypertonics (i.e. DPB greater than or equal to 110 mm Hg = 14.7 kPa) were not significant when comparing groups A and B (2.4% of group A and 4.1% of group B).

Adult↗

PubMed1990

[Adjuvant therapy of lung cancer].

The authors evaluated in a retrospective investigation the effectiveness of adjuvant postoperative chemotherapy (ChT) and radiotherapy (RT), as compared with surgery alone, according to morphological types and stages of cancer lung (CaP). In a group of 321 patients 143 were treated by operation alone, 36 by operation and RT and 53 by operation and ChT. ChT involved administration of Cyclophosphamide, 30 mg/kg, at three-week intervals, some of the patients were also given vincaalkaloids. Therapy was repeated after 6-month intervals. According to the gross mortality data the probability of survival (PP) was compared by Kaplan-Meier's method. Improved PP was proved in patients with small cell lung cancer (MbCa) treated by operation and ChT and in third-stage disease treated by adjuvant ChT. In stage I of CaP adjuvant ChT and RT cause deterioration of the perspective of survival, as compared with operation alone and in stage II adjuvant ChT and RT are no advantage. The authors recommend adjuvant ChT in patients with surgically treated small-cell carcinoma and in stage III of operated CaP. They draw attention to the different response of tumours to adjuvant ChT and RT according to types and stages of CaP, to the fact that RT does not prolong the survival and to the possibility of preoperative ChT and RT in some types and stages of CaP.

Combined Modality Therapy↗

PubMed1990

[Relation of morbidity from gastric and duodenal ulcers with work disability and dispensarization].

A retrospective investigation of the morbidity from peptic ulceration of the stomach and duodenum associated with work incapacity in 1985-1987 in workers of a large engineering factory provided evidence that personal data on this morbidity processed on a computer are along with the medical documentation of individuals a useful source of information for the selection and enlistment of patients into dispensary care and for its evaluation. The investigation revealed at the same time some methodological aspects of dispensarization.

Adolescent↗

PubMed1990

[Effectiveness and reliability of preoperative studies in patients with lung cancer].

The data of documentation of 267 operatively treated patients with lung cancer are shown in a retrospective study. The patients were treated in the clinic for tuberculosis and respiratory diseases of the faculty hospital Plzen. In 50% of the cases the results of histological and cytological examinations correspond with the surgical observations. Results of the pneumomediastinography and the computed tomography of the lung and mediastinum correspond with findings through the operation in 71% and 73% respectively. Through out the last three years the reliability of the cytological diagnosis was increased significantly (p less than 0.01).

Biopsy↗

PubMed1989

[Plasma proteins and other substances in membrane plasmapheresis. Relation to possibilities and limitations of this therapeutic method].

The authors investigated the effectiveness of therapeutic membrane plasmapheresis and its influence on plasma concentrations of 17 proteins, cholesterol, triacylglycerols, urea, creatinine and uric acid. To this end they made 30 operations on monitors A 2008 PF with filters Plasmaflux P 2, where they exchanged one volume of plasma and replaced it with isooncotic albumin. They assessed the plasma concentrations of the investigated substances before, in the course of and after the operation, estimated sieving coefficients during the 15th and 90th minute and the clearance. Under conditions in vivo they confirmed that the sieving coefficients of the investigated substances approach the value of "1" and the clearance of the filtration rate, i.e. that the investigated substances pass easily through the plasmafilter and that plasmapheresis removes the substances non-selectively. They demonstrated that the assessment of plasma concentrations alone can lead to underestimation of the effectiveness of the operation. Assessment of sieving coefficients and clearance makes more adequate evaluation of the effectiveness of the procedure possible. Assessment of sieving coefficients and clearance made it obvious that plasma concentrations do not depend only on the amount of substance removed by plasmapheresis but also on other factors which must be investigated. The authors' findings support efforts to introduce methods for the selective removal of pathogenetic substances.

Blood Proteins↗

PubMed1988