Search PubMed⌕ Search

Biomedical subjects

F Schon

Publications and source records attributed to F Schon.

At least 37 records · Page 2Linked to original sources
PubMed1994

Tetanus: delay in diagnosis in England and Wales.

A 7 day delay occurred in the diagnosis of cephalic tetanus in a 69 year old woman who developed an ipsilateral facial palsy 5 days after a facial laceration. Cranial nerve palsies often precede trismus in this form of tetanus.

Aged↗
PubMed1994

The use of acyclovir in suspected encephalitis.

The early use of intravenous acyclovir in herpes simplex encephalitis (HSE) is essential. However, rapid diagnostic tests are not freely available. Hence, all patients with suspected encephalitis may need to be commenced on acyclovir. In our study, of 34 patients with suspected encephalitis, only two eventually had HSE confirmed, 19 had encephalitis not due to herpes simplex and in 13 a non-encephalitis illness was finally diagnosed. Guidelines for the use of acyclovir in suspected encephalitis are given aimed at minimizing the drug cost whilst still protecting all cases of presumed HSE.

Acyclovir↗
PubMed1993

[Multi-plane transesophageal echocardiography--the next step to 3 dimensional imaging of the heart].

The multiplane transesophageal echocardiography (MTEE) is a new method making the precise imaging of the heart and great vessels possible. That technique allows to obtain the images of cardiovascular structures in two perpendicular investigation planes ("biplane" operation): transverse (examination angle is equal to 90 degrees--in relation to long axis of esophagus) and longitudinal = sagittal (examination angle is equal to 0 degree--in relation to long axis of esophagus) and, as well, in all medial planes enclosed from 0 degree to 90 degrees examination angle. During the investigation planes were being rotated mechanically or manually by rotation wheel. Passing from one plane to another is fluent, due to that the heart and main vessels can be observed continuously. Sector angle variability is 180 degrees (from minus 90 degrees to plus 90 degrees). The investigation planes from 0 degrees to plus 90 degrees from so called "normal" visualization field, and planes from 90 degrees to 0 degree make a "mirror" reflection of the "normal" field (mirror field). In our investigations the Vingmed-Sonotron echocardiograph connected with 5 MHz annular phased--array transducer, placed at the end of flexible endoscope was used. The multiplanar transducers have a full Doppler option (pulsed and continuous waves) with the possibility of colour flow imaging. The initial experience with the new method is presented in this report. The MTEE enables precise assessment of atrial septal defects. The multiplane imaging allows complete evaluation of heart muscle thickness and left ventricular contractility. This technique gives a better visualization of coronary artery. MTEE permits for planimetric assessment of aortic valve.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1992

Histoplasmosis of the central nervous system.

Histoplasma capsulatum infection of the central nervous system is extremely rare in the United Kingdom partly because the organism is not endemic. However, because the organism can remain quiescent in the lungs or the adrenal glands for over 40 years before dissemination, it increasingly needs to be considered in unexplained neurological disease particularly in people who lived in endemic areas as children. In this paper a rapidly progressive fatal myelopathy in an English man brought up in India was shown at necropsy to be due to histoplasmosis. The neurological features of this infection are reviewed.

Adrenal Glands↗
PubMed1992

Cerebral arteriovenous malformation in Noonan's syndrome.

Noonan's syndrome involves the association of multiple congenital abnormalities including neck webbing, pectus excavatum, facial anomalies with a variety of cardiac defects. In this paper the association of Noonan's syndrome with a large cerebral arteriovenous malformation is reported. Congenital cerebrovascular abnormalities are not a recognized feature of the syndrome. The paper also reviews previous reports of neurological associations with Noonan's syndrome, the commonest being mild intellectual impairment and ptosis.

Adult↗
PubMed1991

Epilepsy: disappearing lesions appearing in the United Kingdom.

OBJECTIVE: Investigation of spontaneously resolving lesions associated with epilepsy. DESIGN: Observational study during one year. SETTING: One neurology department. PATIENTS: 4 cases in patients (one of Indian parents, one African, one white English, and one Afro-Caribbean) resident in the United Kingdom, who presented with transient epilepsy. MAIN OUTCOME MEASURES: Findings on computed tomography and on screening for infections. RESULTS: In all four cases a small mass lesion in one cerebral hemisphere was observed on computed tomography, which resolved after 9, 4, 3 and 1.5 months respectively without surgery. CONCLUSIONS: The number of cases seen in one year suggests that the lesions may be more common in the United Kingdom than previously recognised and that research into their cause is warranted.

Adolescent↗
PubMed1991

Neurosarcoidosis--demonstration of meningeal disease by gadolinium enhanced magnetic resonance imaging.

Arriving at a firm diagnosis of neurosarcoidosis continues to pose serious problems, particularly when evidence of granulomatous disease outside the nervous system is lacking. The commonest mode of presentation of neurosarcoidosis is with cranial nerve palsies. Two cases of presumed neurosarcoidosis with cranial nerve palsies showed clear evidence of focal meningeal disease on gadolinium-DTPA enhanced MRI brain scans. Although not specific for sarcoidosis, this technique may be very useful in aiding the diagnosis in suspected cases.

Aged↗
PubMed1990

Syringomyelia and syringobulbia following tuberculous meningitis.

Tuberculous meningitis may rarely be followed by the development of a syrinx even after apparently successful chemotherapy. There are only six previously reported cases of this unusual complication; these are reviewed. A case is described of syringomyelia which developed 1 year after TBM. One year later magnetic resonance imaging demonstrated not only the spontaneous resolution of the syringomyelia but also the appearance of a new cavity within the brain stem. This surprising sequence of events illustrates the need for extensive studies of the natural history of syrinxes of differing aetiologies.

Adult↗
PubMed1989

The origins of utilization behaviour.

Utilization behaviour has previously been described clinically by Lhermitte (1983). An experimental investigation is reported of utilization behaviour in a patient with a localized inferior medial bifrontal lesion. The patient picked up and used irrelevant objects not only when place directly in front of him--the procedure developed by Lhermitte--but also when he had been instructed to carry out other tasks and his attention had not been directed to the objects. The behaviour occurred most frequently in the brief intervals between tasks, and more often when auditory-verbal rather than visuomotor tasks were being performed. The results are interpreted within an information-processing model of frontal lobe function. A differentiation is made between two forms of utilization behaviour--an 'incidental' form, as exhibited by the patient, and an 'induced' form where it occurs only when Lhermitte's procedure is adopted.

Behavior↗
PubMed1987

Pathogenesis of post-herpetic neuralgia.

A model of post-herpetic neuralgia is put forward based on the physiological effects of herpes simplex type-1 virus infection of rat dorsal root ganglion neurons in tissue culture. This virus causes these normally electrically silent neurons to produce spontaneous action potentials. Furthermore, pairs of neurons tend to have synchronised discharges. This coupling is not synaptically mediated, but due to presumed electrical junctions. It is proposed that post-herpetic neuralgia is caused by abnormal impulses arising in dorsal root ganglion neurons as a direct result of viral infection.

Action Potentials↗
PubMed1987

Adult onset supranuclear ophthalmoplegia, cerebellar ataxia, and neurogenic proximal muscle weakness in a brother and sister: another hexosaminidase A deficiency syndrome.

An Ashkenazi Jewish brother and sister developed progressive ataxia and proximal neurogenic muscle weakness, associated with supranuclear ophthalmoplegia, in the fourth decade of life. Hexosaminidase A activity, assayed using both synthetic and natural substrates, was severely reduced in the patients' plasma, leukocytes, and skin fibroblasts. Enzyme activity in their parents was in a similar range to that seen in heterozygotes for Tay-Sachs disease. The increasing evidence for marked clinical and molecular heterogeneity in the GM2 gangliosidoses warrants their consideration in the diagnosis of multisystem degenerative neurological disorders, even if onset of symptoms is in adult life.

Age Factors↗