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Biomedical subjects

F Schlaeffer

Publications and source records attributed to F Schlaeffer.

At least 91 records · Page 5Linked to original sources
PubMed1988

Cerebral infarction associated with oral verapamil overdose.

Verapamil is a widely used calcium channel blocker. Side effects with oral use are usually mild, however, major hemodynamic complications and death can occur if the drug is given in overdose. We describe a case of cerebral infarction associated with attempted suicide with verapamil overdose, the first reported to our knowledge.

Adult↗
PubMed1988

Oxacillin-associated hypokalemia.

Antibiotic-induced hypokalemia does not occur frequently, but has been described with aminoglycosides, amphotericin B, and ureido penicillins. A patient with Staphylococcus aureus bacteremia who developed severe hypokalemia while on high doses of oxacillin is presented. To our knowledge this is the first reported case of oxacillin-associated hypokalemia.

Electrocardiography↗
PubMed1987

Technetium Tc 99m diphosphonate bone scan. False-normal findings in elderly patients with hematogenous vertebral osteomyelitis.

Hematogenous osteomyelitis is usually diagnosed by an abnormal technetium Tc 99m diphosphonate bone scan in symptomatic patients who have positive blood cultures. False-normal 99mTc bone scans have been described recently in neonates with biopsy-proved osteomyelitis. This phenomenon seems to be extremely rare in adults. Two elderly patients with hematogenous vertebral osteomyelitis had normal technetium Tc 99m diphosphonate bone scans when first evaluated. In both cases the bone scans became abnormal four to six weeks after onset of symptoms and two to four weeks after the initial normal results of the study. When suggested by the clinical picture, hematogenous osteomyelitis cannot be ruled out by a normal 99mTc bone scan at any age. Gallium scan, computed tomographic scan, or bone biopsy can be helpful in such cases.

Aged↗
PubMed1987

Cytomegalovirus mononucleosis--a report of 70 cases in a community hospital.

Seventy consecutive cases of cytomegalovirus mononucleosis (CMV-MN) were examined retrospectively from their clinical, epidemiological and serological aspects. The mononucleosis syndrome was complicated by various specific organ involvement in 15 (21%) of the patients. Serial serum samples were examined for specific CMV IgG, IgA and IgM antibodies by either the immunoperoxidase or enzyme-linked immunoassay techniques, or both. Specific anti-CMV IgM antibodies were found in 57 patients whose blood samples were collected for the first time at the second week of illness. In seven patients, CMV infection was diagnosed by a rise of specific IgG antibodies and the presence of specific IgA antibodies. These seven patients were generally older (mean age 68 years); four of them had a malignant disease and probably represent cases of recurrent CMV infection. An association between malignancy and recurrent CMV infection in the older age-group is suggested. Prompt diagnosis of CMV infection may exclude CMV-MN from the list of fevers of unknown origin, thus avoiding laborious patient workups.

Adolescent↗
PubMed1985

Pneumococcal infections among immunised and splenectomised patients in Israel.

Pneumococcal sepsis is a life-threatening complication in splenectomised patients even since the introduction of a polyvalent pneumococcal vaccine. Eight episodes of pneumococcal sepsis in seven properly vaccinated splenectomised patients are described. All but two of the causative serotypes were included in the vaccine. The fact that most of the patients were immunosuppressed may explain the failure of the vaccine in these particular patients. A survey of 59 episodes of pneumococcal bacteraemia during 1982 at the Soroka Medical Center, however, shows that 32% of the strains of pneumococci isolated were among seven types not included in the vaccine. The addition of continuous antibiotic prophylaxis in vaccinated and splenectomised patients is suggested.

Adult↗
PubMed1985

Immunoblastic lymphoma and thymic epithelial hyperplasia in angioimmunoblastic lymphadenopathy following gold therapy.

A 62-year-old woman with well-established polyarthritis developed angioimmunoblastic lymphadenopathy (AILD) during gold therapy. She subsequently developed an immunoblastic lymphoma which showed monoclonality (IgA, lambda) by immunoperoxidase techniques. There was a tumor-like enlargement of the thymus gland due to involvement by AILD, with secondary proliferation of thymic epithelium. The finding of thymic involvement, which has not been described previously in AILD, might be one of the manifestations reflecting a disturbance of the immune system in this disease.

Arthritis, Rheumatoid↗
PubMed1985

Mediterranean spotted fever in an American woman.

Mediterranean spotted fever is common in southern Europe, the Middle East, and North Africa, but is unknown in the United States. It has a clinical picture resembling Rocky Mountain spotted fever, but it is a milder disease. We report a case of Mediterranean spotted fever in a young American woman returning from Morocco and review the clinical picture of this disease.

Adult↗
PubMed1985

Amiodarone-induced dysthyroidism.

A 54-year-old man, treated with amiodarone, developed thyrotoxicosis. When rechallenged with the same drug 6 months later, he developed hypothyroidism. The therapeutic implications of this clinical sequence are discussed.

Amiodarone↗
PubMed1984

Effect of exercise and environmental heat on theophylline kinetics.

The pharmacokinetics of theophylline were studied in 6 healthy volunteers at rest, during light and moderate exercise and during exercise in a hot environment. Exercise was performed between 2 and 4 h after oral ingestion of theophylline in solution at a dose of 200 mg/m2 body surface. Significant prolongations of the half-life (t1/2) of the drug and reductions in its body clearance were observed during exercise to 30% of VO2, max both at 22 and 40 degrees C, as well as during exercise to 50% of VO2, max at 22 degrees C. t1/2 was (mean +/- SEM) 8.5 +/- 0.8, 8.0 +/- 1.0 and 7.2 +/- 1.0 h at the three exercise sessions, respectively, compared with 6.4 +/- 0.9 h at rest. Plasma clearances at the three exercise sessions were 0.70 +/- 0.09, 0.62 +/- 0.1 and 0.75 +/- 0.09 ml/min/kg, respectively, compared with 0.99 +/- 0.13 ml/min/kg at rest. The apparent volumes of drug distribution (Vd) decreased significantly at the 50% and the 30% exercise in the heat, suggestive of some dehydration. The areas under the concentration-time curves (AUC0-infinity) and the elimination rate constants (Kel) also changed significantly under the different experimental conditions. It is suggested that appropriate dose adjustments may have to be made in moderately active patients who are treated with theophylline.

Administration, Oral↗
PubMed1983

Cisplatin-induced bradycardia.

A patient who had repeated episodes of bradycardia while on cisplatin therapy is described. Cisplatin-induced bradycardia has not been reported previously. Deposition of cisplatin in the sinoatrial-node area might explain this cardiotoxic effect.

Bradycardia↗
PubMed1983

Multiple autoimmune manifestations in a splenectomized subject with HLA-B8.

Idiopathic thrombocytopenic purpura developed in a 31-year-old man, and he underwent a splenectomy because of his failure to respond to steroid therapy. Subsequently, during a six-year follow-up, chronic active hepatitis, Coombs' positive hemolytic anemia, and pulmonary interstitial fibrosis developed. Since such a clustering of autoimmune manifestations in a single subject is unusual, possible contributing factors were sought. We suggest that both the splenectomy and the histocompatibility antigen HLA-B8, which the patient was found to carry, may have contributed to this rare clinical syndrome.

Adult↗