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Biomedical subjects

F Schier

Publications and source records attributed to F Schier.

At least 73 records · Page 4Linked to original sources
PubMed1990

[Complications of colostomy in childhood].

The complications of 86 colostomies in 70 patients are reported. The most frequent indications were necrotizing enterocolitis and Hirschsprung's disease. More than half of the children were less than one week of age at the time of surgery. Most frequently transverse colostomies were performed. Most colostomies existed for 1-3 months. In 58% of the children no complications occurred, which could be attributed to the colostomy. Thus, the complication rate of the colostomies was 42%. The most common complications were strictures, adhesions with bowel obstruction, enterocutaneous fistulae, occasionally leading to abscess formation, and candida mycosis.

Abscess↗
PubMed1990

[Duodenal atresia. Experiences with 145 patients].

145 children with duodenal atresia were operated on between 1971 and 1988. 57 were premature, 48 newborn, 11 toddlers and 5 older children. Once the immediate perioperative phase is overcome, the postoperative prognosis is determined only by the severity of associated anomalies. Most atresias were found to be located prepapillary. Trisomy 21, malrotations and vitium cordis were the most frequent associated anomalies. Relaparotomies were required in 21%, mostly because of adhesions.

Abnormalities, Multiple↗
PubMed1989

The influence of various amino acids on the extrahepatic bile ducts in newborn mice--an experimental study.

Excess proline in adult animals is associated with extrahepatic biliary hyperplasia. Possible therapeutic application of this amino acid in biliary atresia was postulated. In order to test whether excess proline had an influence on the development of the extrahepatic bile ducts, pregnant mice were injected daily with various amino acids. One day and 1 week after delivery, the extrahepatic bile ducts of the newborn mice were studied and the number of epithelial cells per cross section was determined. Neither proline nor any other amino acid had an influence on the proliferation of extrahepatic bile ducts.

Amino Acids↗
PubMed1989

[Initial measures in newborn infants with surgically correctable abnormalities].

In newborns with surgically correctable malformations the quality of primary care has considerable influence on the results of the eventual surgical repair. This is particularly true for extensive diaphragmatic and abdominal wall defects as well as for esophageal and intestinal atresia, exstrophy of the bladder and urogenital malformations. The neonatal management comprises measures generally valid for all diseased newborns and measures specific for the particular malformation. The general care concerns heat regulation, fluid balance and other vital functions. Specific regimens are necessary as primary care for diaphragmatic hernia, esophageal atresia, abdominal wall defects and neonatal bowel obstruction. Furthermore this primary management must be extended to include the care of the pregnant mother. Already in utero infants with diaphragmatic and esophageal malformations should be referred to the gynecological-neonatal center.

Abnormalities, Multiple↗
PubMed1988

Characterization of human extrahepatic biliary duct epithelial cells in culture.

In order to study human bile duct cells in vitro, cystic ducts were obtained during cholecystectomy and treated with collagenase and mechanical abrasion to isolate biliary epithelial cells. The culture medium was supplemented with 50% of a bovine bile duct conditioned medium obtained by incubating minced bovine extrahepatic bile ducts for 24 hr in Dulbecco's modified Eagle's medium. Cells grew in monolayer and showed contact inhibition at confluency. The epithelial origin of primary cultures was verified by their growth pattern, ultrastructure, and indirect immunofluorescence for cytokeratin. The cultures showed specific immunofluorescence for lysozyme, collagen types I, III, and IV, fibronectin, and laminin, but were negative for collagen type V and factor VIII-associated antigen. Thus, these cultures provide an experimental model for the in vitro study of biliary atresia and other bile duct diseases.

Animals↗
PubMed1988

[Bile duct epithelium and bile duct atresia].

In order to investigate pathogenetic theories about the origins of biliary atresia, a model consisting of cell cultures of bile duct epithelium from the extrahepatic ducts of human and bovine origin is presented. The epithelial nature of the cultivated cells was documented by phase contrast microscopy, by electron microscopy and immunohistochemistry (anti-keratin). Inoculation studies of primary human cell cultures showed a cytopathic effect by light microscopy for all tested viruses (adeno, polio, herpes, rubella) except for reovirus type 3, for which a CPE was not demonstrable. A growth stimulating substrate for bile duct epithelial cells is described; among the purified growth factors epidermal growth factor was without effect (EGF), while cholecystokinin (CCK) led to an increase in cell numbers.

Animals↗
PubMed1988

[Diagnostic localization and postoperative results of hormone-producing tumors of the adrenal cortex--review of 51 cases].

51 surgically treated cases with hormone-producing tumours of the adrenal cortex are evaluated for the reliability of preoperative localisation of diagnostic measures and postoperative results. 6 patients were children. The group contains 14 cases of Conn's syndrome, 32 cases of hypercortisolism, including 3 children, and 5 cases of AGS, 3 of which were children. The recommended work-up procedure is initiated by ultrasonography and followed by CT, possibly in combination with adrenal scintigraphy. This combination of a morphological and functional investigation established the correct diagnosis in all 51 cases. Laboratory values returned to normal levels in all cases, phenotypical aspects normalised in most cases. Deaths and complications occurred only in hypercortisolism and AGS.

Adenoma↗
PubMed1988

[A new device for long gap esophageal atresia].

A new mechanical device is presented which approximates the two oesophageal pouches in long gap oesophageal atresia and possibly creates an anastomosis. The principle is similar to magnetic bougienage, only that purely mechanical force is employed instead. This offers several advantages: the instrument is considerably less bulky, technically simple, inexpensive, light and therefore easy to transport. Only normal electrical current is necessary. The tensile forces applied are easier to control. The child does not have to be placed inside a tube and is not restrained in its movements. The device has been experimentally tested in 6 dogs.

Animals↗
PubMed1988

[193 cases of gastroschisis and omphalocele--postoperative results].

Treatment was applied to 97 cases of omphalocele and 96 cases of gastroschisis at the Dortmund Department of Paediatric Surgery over the past 20 years. The survival rate was 122. Follow-up checks were recently applied to 56 of those former patients, after nearly ten years had elapsed from surgery. Thirty-eight of these patients were clinically examined, while questionnaires were completed for the rest. Primary closures had been performed on 50 per cent of the cases, while the defects in the other children were closed in two stages, using dura implantation or silastic pouches, or were conservatively treated. Accompanying malformations were recorded from 21 per cent of the gastroschisis cases and from 28 per cent of those with omphalocele. Overall mortality accounted for 37 per cent, with mortality in the wake of receptive operations being as high as 40 to 50 per cent, the latter rate not depending on the primary approach. One and the same risk was found to exist for conservative treatment (applicable only to closed omphalocele) and primary surgical closure, as may be seen from statistical evaluation. The highest rate of relaparotomy occurred in the wake of dura implantation and use of silastic pouches.

Abdominal Muscles↗
PubMed1987

Cell cultures of bile duct epithelium and the pathogenesis of biliary atresia.

The pathogenesis of biliary atresia is unknown. The authors describe a technique for culturing extrahepatic bile duct epithelial cells of human and bovine origin in monolayer cell cultures. Light-, electron microscopy and immunohistological studies prove the epithelial nature of the cultured cells. Inoculation of the cells with reovirus 3 showed no destruction; adenovirus 6, herpes simplex and polio virus 1 and 2 destroyed the cells within 24 h. The cells produce a growth factor maintaining the integrity of the cells, even in the absence of serum.

Animals↗
PubMed1987

[Esophageal replacement with resorbable vicryl tubes--an animal experiment study].

In order to study a novel resorbable oesophageal prosthesis, four centimetres of cervical oesophagus were replaced by a Vicryl tube in 26 dogs with an average weight of 16.9 kg. The implants were removed after 2, 4, 8 days and after 2, 4, 6, 8 and 10 weeks. 19% of the animals died; not counting three dogs which were sacrificed earlier than planned, the overall lethality was 8%. Dehiscences occurred in 75%, of which 2/3 closed spontaneously within the first 10 days. Stenoses developed in 87%. All dogs had difficulty in swallowing. A fibrous tube with complete epithelial lining formed around the prosthesis within two weeks. Following this the prosthesis was lifted off and expelled per vias naturales.

Animals↗
PubMed1987

[Cell cultures of the epithelium of the bile ducts: a possible model for the study of atresia of the bile ducts].

The pathogenic mechanism of biliary atresia is still unknown. Assuming that primary lesion is localized at the epithelial layer of the biliary ducts, authors describe a technique of culturing biliary duct cells in monolayer fashion. Light and electron microscopy demonstrate the epithelial origin of the cultured cells. These cells can be used to test some of the pathogenic theories in vitro hitherto proposed.

Animals↗
PubMed1987

[Abnormalities in positioning and shape of the intestines in children].

Volvulus, ileus, and internal herniation may be consequences of intestinal malposition in childhood. Bacterial overgrowth, obstipation, diarrhoea, and malabsorption may additionally develop over time in the absence of adequate treatment. One in three positional abnormalities is diagnosed only intraoperatively. The surgeon has to expect such surprise findings as a condition for adequate therapeutic action.

Child↗
PubMed1987

[Late results following surgical therapy of Hirschsprung disease].

Re-assessment was made of 21 children roughly 14 years after operations for Hirschsprung's disease, using Rehbein's technique. Mortality accounted for ten per cent. Relaparotomy was necessary in 20 per cent of the cases. Anastomotic leakage was recorded from 8 per cent and small bowel obstruction due to adhesions from 7 per cent. Obstipation, diarrhoea, and fecal soiling were recorded from 5 per cent each. None of the children exhibited fecal or urinary incontinence. These results are compared with a statistical record on follow-up checks made between 8 and 27 years after surgery.

Adolescent↗
PubMed1986

Rasterstereography in the measurement and postoperative follow-up of anterior chest wall deformities.

Rasterstereography is a contact-free photogrammetric method for the measurement of body surfaces. As such it is particularly suited for the objective documentation of anterior chest wall deformities and the results of surgery. An example of its application and first results are presented. The possibilities of a thorough data analysis with regard to diagnosis and therapy control are outlined.

Adolescent↗
PubMed1981

[Surgery of Crohn's disease: a study of 155 patients after intestinal resection (author's transl)].

Operative mortality after intestinal resection in 155 patients with Crohn's disease was 8.4%. In 12 of 13 the cause of death was septic complications, most of them related to prolonged pre-operative cortisone medication. Follow-up examination was possible in 90% of all discharges. Five-year recurrence rate was 37.6%. Recurrence was not prevented by long-term drug treatment. Purely macroscopic assessment of the resection margins would have led to excision within diseased gut: for this reason frozen sections are recommended before the anastomosis is made. Primary death-rate in 30 cases of colectomy with primary ileorectostomy was 3%. In three patients the rectum had to be excised, while in one the anastomosis had to be taken down because of recurrence. The failure rate was thus only 11%. If rectoscopy, stepwise biopsy and intra-operative frozen section indicate a normal rectum it is recommended that ileorectostomy be done rather than diversion ileostomy with occlusion of the rectum or even proctocolectomy.

Colectomy↗
PubMed1979

Ostium resistance in acute maxillary and frontal sinusitis.

Ostium function tests were performed in 18 normal maxillary and 6 normal frontal sinuses. Further 57 patients with acute maxillary and 16 patients with acute frontal sinusitis were followed using sinumanometry until resolution of infection occured. After initial obstruction of the ostium, resistance decreased exponentially until complete decongestion. Respiratory pressure changes in the sinus during forced nasal breathing are a positive sign for healing of sinusitis. The amplitude of these fluctuations should be documented during each lavage and facilitates indication for drainage procedures.

Adult↗