[Pathological variations, in relation to ontogenesis, of the multiple molecular forms of lactate dehydrogenase, creatine kinase and aldolase].
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Animals↗
Biomedical subjects
F Schapira
Publications and source records attributed to F Schapira.
[Biochemistry of striated muscle in the course of human muscular diseases].
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Adenine Nucleotides↗
[Hepatic aldolase in fructose intolerance].
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Carbohydrate Metabolism, Inborn Errors↗
The value of serum enzyme determinations in the identification of dystrophic carriers.
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Aging↗
[Changes in the isozymes of muscular creatine-kinase during atrophy].
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Animals↗
[Inhibitory action of adenosine triphosphate on human hepatoma aldolase].
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Adenosine Triphosphate↗
Fetal-like patterns of lactic-dehydrogenase and aldolase isozymes in some pathological conditions.
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Animals↗
[Different action of insulin on the creatine kinase of rabbit muscle and brain].
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Animals↗
[Modification of cancer aldolase in mouse spleen reticulosarcoma].
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Animals↗
[Factors of the biosynthesis of isozymes].
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Animals↗
[The isozymes of lactico-dehydrogenase of the erythrocyte].
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Erythrocytes↗
[New data on pathologic enzymology].
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Carbohydrate Metabolism, Inborn Errors↗
Isozymes and differentiation.
We have tried to define "isozymes" and "differentiation" because these words are often used in a too vague sense. We have noted that the physiological role of isozymes is far from being clearly understood, even for the most studied enzyme with multiple molecular forms, lactic dehydrogenase. But we have pointed out that some isozymes are specific for some adult tissues, especially liver and muscle. They constitute consequently true "markers" of differentiation. Some mechanisms of this differentiation have been made clearer by the experiments of cell hybridization. The role of isozymes in differentiation is also illustrated by the selective disappearance of isozymic markers in some pathologycal conditions, for example : cancer and muscular diseases.
Cell Differentiation↗