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Biomedical subjects

F Savoldi

Publications and source records attributed to F Savoldi.

At least 109 records · Page 6Linked to original sources
PubMed1979

[Long-term treatment with lithium salts and cerebral electric activity. Experimental research].

An eeg study was carried out in rabbits to investigate the neurophysiological effects of chronic lithium clorure treatment. The Monnier and Gangloff's stereotaxic method was used for recording cortical and deep structure activity. Lithium clorure was administered i.p. at doses of 20 mg/Kg/die for 15-22 days (mean plasmatic levels: 0.04 mEq/l). The eeg changes consisted in synchronization of the cortical activity, slowing of the deep structure activity and increase of CAD spiking. The most interesting finding was the appearance of peculiar periodic spikes in the CAD and subcortical structures. A similar pattern has been previously described by us in rabbits treated with repeated ECT.

Animals↗
PubMed1979

[Floctafenine in the treatment of painful syndromes of neurologic interest].

The clinical results obtained with phloctaphenin in an "open" study comprising cases of real neuralgia and spinal radicular pain syndromes and in a "double-blind" study comparing the preparation with a placebo, and involving algico-vasomotor syndromes of the face, are reported. The results obtained confirm the antalgic power of phloctaphenin for by the third day, subacute or chronic pain syndromes already presented a significant improvement in simptomatology, while in algico-vasomotor syndromes of the face, the treatment proved effective in eliminating pain attacks.

Administration, Oral↗
PubMed1979

Antagonism between dopaminergic and neuroleptic drugs. I. Acute administration.

In this paper we report our results concerning the antagonism between dopaminergic (bromocriptine, apomorphine, piribedil) and neuroleptic (haloperidol, chlorpromazine, reserpine, clotiapine) drugs on the eeg and behaviour of rabbits. The Monnier and Gangloff stereotaxic method was used in order to record cortical and deep structures. The use of neurophysiologic methods also enabled us to verify the magnitude and modes of the antagonism between the two types of drugs. Particularly, the dissociation between eeg and behavioural effects of this antagonism is discussed; this fact seems to confirm the hypothesis that dopaminergic drugs have a double point of attack in the CNS.

Animals↗
PubMed1979

Antagonism between dopaminergic and neuroleptic drugs. II. Chronic administration.

In this work the eeg and behavioural effects obtained after the administration of dopaminergic drugs (bromocriptine, apomorphine, piribedil) in rabbits chronically pretreated with haloperidol, chlorpromazine, clotiapine, are shown. The Monnier and Gangloff stereotaxic method was used. The aim of the study was to verify receptor supersensitivity by neurophysiologic methods. The neurophysiologic pattern of receptor supersensitivity induced by long-lasting treatment with neuroleptic drugs and its peculiarity are discussed.

Animals↗
PubMed1979

Benserazide induces migraine attacks. Irrelevance of concomitant hyperprolactinemia.

Migrainous women underwent acute administration of sulpiride (25 mg i.v.) and benserazide (125 mg per os), both drugs increasing prolactin secretion. A similar increase in prolactin levels was found following the administration of the two drugs. A typical migraine attack was observed only in the 4 women given benserazide. These data, though being preliminary, stress the scarce or irrelevant role of prolactin in the pathogenesis of the migraine attack.

Adult↗
PubMed1979

Dopamine-agonist drugs and cerebral electrical activity in the rabbit.

The eeg changes induced by acute administration in rabbits of dopamine-agonist drugs (bromocriptine, apomorphine, piribedil) were studied. We examined the spontaneous electric activity of cortex and deep structures, the electric excitability thresholds and the action of these drugs in "cerveau isolé" rabbit. Eeg findings were correlated with behavioural reactions. The modes of action and the probable double point of attack of the drugs at the CNS are discussed.

Animals↗
PubMed1977

Comparative Doppler directional sonographic and ophthalmodynamographic study in the occlusion of the internal carotid artery.

In the occlusion of the internal carotid artery, the change occurring in the internal-external carotid pressure gradient may cause flow reversal within the ophthalmic artery and its branches. Ophthalmodynamographic, Doppler directional sonographic and angiographic investigations were performed in 21 cases (11 total occlusions, 6 severe and 4 moderate stenoses of the internal carotid artery). The authors compare the results of these investigations and discuss the practical importance of Doppler directional sonography and the significance of flow reversal in the ophthalmic artery.

Adult↗