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Biomedical subjects

F Sartor

Publications and source records attributed to F Sartor.

8 recordsLinked to original sources
PubMed1992

P-glycoprotein but not topoisomerase II and glutathione-S-transferase-pi accounts for enhanced intracellular drug-resistance in LoVo MDR human cell lines.

The biochemical bases of the multidrug-resistant (MDR) phenotype were investigated in drug-resistant sublines derived from LoVo human colon carcinoma cell lines by doxorubicin (DOX) and teniposide (VM26) selection. In addition to P-glycoprotein-mediated drug extrusion through the plasma-membrane, LoVo MDR cells display a further drug-resistance mechanism. That is, to achieve equitoxic effects, LoVo MDR sublines require much higher intracellular drug concentrations than those required by LoVo drug-sensitive parent cell line. Involvement of mdr1, topoisomerase II and glutathione-S-transferase-pi (GST-pi) drug-resistance systems in intracellular drug resistance was investigated. Pharmacologic and biochemical data indicated that intracellular drug resistance in LoVo MDR sublines is uniquely consequent to the drug-transporting property of intracytoplasmic membrane-bound P-glycoprotein molecules which compartment drugs in vacuole-like structures.

ATP Binding Cassette Transporter, Subfamily B, Mem↗
PubMed1992

Factors influencing the cadmium body burden in a population study.

The cadmium body burden, as estimated from 24-h urinary cadmium (Cd-U), was determined in 1523 non-occupationally exposed subjects living in five areas of Belgium. It increased with age until 55-65 years in both sexes and thereafter decreased slightly. It was higher in smokers but was inversely associated with alcohol consumption and social class. In men only, it was also positively correlated with body mass index. After the menopause, women showed a significant increase in 24-h Cd-U independently of the other factors. In addition, the cadmium body burden was independently associated with place of residence in both sexes. Highest levels of Cd-U were found in subjects living in an area with soils heavily polluted by cadmium.

Adolescent↗
PubMed1992

Analytical quality control of cadmium and lead in blood and cadmium in urine: results of its implementation during a five-year epidemiological study.

Quality-control programmes are very important in assessing the reliability of biological analyses. Such programmes are essential if misleading results in epidemiological studies dealing with low levels of exposure to heavy metals present in the general environment (e.g., cadmium, lead) are to be avoided. Internal and external quality-control programmes for the measurement of cadmium and lead in blood and of cadmium in urine were implemented from 1985 to 1989 in support of a national epidemiological study, Cadmibel (2327 participants), conducted in Belgium to assess the effects of environmental exposure to cadmium and lead on the general population. Apart from these programmes, inter-comparisons between the two participating laboratories were carried out on 10% of the samples. The results of these quality-control programmes met external acceptability criteria, emphasizing the analytical proficiency of these measurements at the relatively low concentrations in the Cadmibel study.

Cadmium↗
PubMed1991

The association between blood pressure, calcium and other divalent cations: a population study.

This report investigated the associations between blood pressure and the levels of various divalent cations in blood and urine in the population at large. The 1,982 participants (963 men and 1019 women; mean age 48 years) constituted a stratified random sample of the population of 4 Belgian districts. Systolic/diastolic pressure averaged 133/78 mmHg in men, and 128/76 mmHg in women. Serum total calcium (2.37 mmol/l), serum magnesium (1.00 mmol/l) and blood cadmium (10.0 nmol/l) were on average similar in the two sexes. By contrast, serum zinc (13.1 and 12.6 mumol/l, respectively), blood lead (0.56 and 0.36 mumol/l) and the urinary excretions of calcium (4.86 and 3.95 mmol/24h), copper (0.16 and 0.13 mumol/24h), and cadmium (9.4 and 7.2 nmol/24h) were significantly higher in men than in women. After adjustment for significant blood pressure covariates (age, body mass index, pulse rate, log gamma-glutamyltranspeptidase, smoking habits, and in women the contraceptive pill), serum total calcium was independently and positively correlated with systolic pressure in both sexes, and with diastolic pressure in women. After similar adjustments systolic pressure was positively correlated with urinary copper in men and women. In addition, systolic pressure and blood lead, and diastolic pressure and urinary cadmium were negatively correlated in men. In conclusion, this population study demonstrated a positive relationship between systolic blood pressure and both serum total calcium and urinary copper.

Adult↗
PubMedDate not supplied

Decrease in blood cadmium levels over time in Belgium.

During the time period from 1984 to 1988, blood cadmium concentration decreased by 56% in 31 males who were not occupationally exposed to cadmium and who lived in a Belgian urban area where there existed nonferrous industries. A 40% decrease in blood cadmium concentration was also observed in an independent cross-sectional survey conducted in 1985 and 1988 among 412 subjects who lived in a rural area. This latter decrease persisted when the main determinants of blood cadmium concentration--gender, age, and tobacco--were allowed for. The results presented are consistent with a decrease in environmental cadmium exposure in Belgium.

Adult↗