Platelet count and platelet function (circulating platelet aggregates, retention by glass beads and aggregation) were studied under basal conditions and after a cycloergometric exercise test in 10 subjects with stable angina pectoris and 10 normal subjects. There were no baseline differences between patients and controls in any of the tests of platelet function, nor did the values change after the exercise test. There was, however, a significant increase in the number of circulating platelets after the test in angina patients. Possible reasons for this phenomenon are discussed, with emphasis on the role of catecholamine hypersecretion induced by the physical exercise.

Adult↗

PubMedDate not supplied

The VO2 slow component in swimming.

All studies on the oxygen uptake (VO2) slow component have been carried out for the sporting disciplines of cycling or running, but never for swimming. Considering that front crawl swimming is a sport discipline that is fundamentally different from both running and cycling, the aim of this study was to verify whether this slow component also appears in swimming. Six elite pentathletes were tested in a swimming flume while front crawl swimming to exhaustion. Swimming velocity for the slow component test was determined as v50% delta = CV + [vVO2peak - CV)/2], where CV is the critical velocity and vVO2peak the lowest velocity at which peak VO2 occurred. To set the subject's CV, expressed as the slope of a straight line that describes the correlation between swimming distance and time, the record times over three swimming distances were recorded in a 50 m swimming pool. The vVO2peak was measured by means of an incremental test in the swimming flume. Gas exchange was measured by means of a telemetric metabolimeter (K4 RQ, Cosmed, Italy) that was connected to a snorkel. The slow component was found in all subjects, with a mean (SD) value of 239 (194) mlO2.min-1. Therefore, although front crawl swimming is fundamentally different from both running and cycling, it appears that it also incurs a VO2 slow component. The origin of this phenomenon, however, is even more uncertain than for the other sport disciplines.

Adolescent↗

PubMedDate not supplied

Is there a real treatment for stroke? Clinical and statistical comparison of different treatments in 300 patients.

In the absence of universally accepted criteria for the medical treatment of stroke, we made a rigorously randomized comparative study of different treatments in 300 patients. One group of patients received only a general supportive treatment designed to ensure adequate supplies of water, electrolytes and calories, plus whatever was needed to prevent infection and correct extant associated pathology. Three other groups of patients were treated in the same way but were also given, respectively, one of the following medications: Hydergine (Sandoz) (a mixture of three ergot alkaloids), dexamethasone, and mannitol. No statistically significant difference emerged among any of the treatment groups and the reference group in terms of objective therapeutic results. The authors concluded that, at least with the dosage used in this study, none of the treatments proved more useful than conventional supportive therapy in the first 10 days after a stroke.

Aged↗

PubMedDate not supplied