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Biomedical subjects

F Santos

Publications and source records attributed to F Santos.

At least 109 records · Page 6Linked to original sources
PubMed1985

[Nephropathy of the Schöenlein-Henoch syndrome: long-term prognosis in non-selected patients].

Nephritis plays a major role in long-term prognosis of Schönlein-Henoch syndrome. We have studied a group of 142 children with this syndrome; 43 (30.2%) showed clinical evidence of renal disease. Renal biopsy was obtained in 12 cases. A subgroup of 36 patients have been controlled during a much greater two years period. Thirty-five are asymptomatic and one with minor urinary anomalies. Thereafter in our experience the long-term prognosis (means = five years) of Schönlein-Henoch syndrome is excellent in unselected patients.

Adolescent↗
PubMed1981

Pharmacokinetics of amikacin in children with normal and impaired renal function.

The pharmacokinetics of the antibiotic amikacin sulfate were studied in eight children with normal renal function and in ten children with varying degrees of renal impairment. All patients received a single i.v. dose of 7.5 mg/kg of the antibiotic. Amikacin follows a two-compartment open-kinetic model. The serum half-life, which in children with normal renal function has an average value of 1 hour, reached values of 14 hours in children with severe renal impairment. A lineal relationship is established between the beta constant and the creatinine clearance (Clcr) according to the equation beta = 0.001 + 0.005.Clcr, with r = 0,818. From thie equation, the dosage interval is modified to maintain the serum concentrations of the antibiotic within the therapeutic interval.

Amikacin↗
PubMed1980

[C reactive protein as a standard of efficience in antiinfectious therapy (author's transl)].

C reactive protein (CRP) levels are sequencially settled in 58 children, divided in three groups in dependence of their illness: acute bacterial pneumopathy, acute pyelonephritis or neonatal sepsis, all of them receiving antibiotic treatment. CRP values are compared with clinical, radiologic and bacteriologic findings, showing in patients of the first two groups a normalization between fourth and ninth day of treatment, together with clinical and radiologic improvement. In contrast, it was shown that normalization of CRP in neonatal sepsis group was quite slow related to the torpid evolution. The sequentially measure of CRP was prove useful as antibiotic treatment control in children affected with different infectious pictures.

Anti-Bacterial Agents↗
PubMed1980

[Diagnostic value of C reactive protein in neonatal sepsis (author's transl)].

Seric levels of C reactive protein (C.R.P.) were determined in a series of 125 children under one month old. Of them, 75 were clinically healthy and 50 showed signs that suggested infection. In all this infants, in addition to C.R.P., different components of white blood cell differential count were determined, and a bacteriological study was undergone. Authors found high concentration of C.R.P. in 100% of children in which diagnosis of sepsis was bacteriologically confirmed. On the other hand, concentrations of this biological parameter were not substantially modified in newborns used in the control, nor in those other ones in which sepsis was not confirmed. Sensibility of C.R.P. showed itself significantly higher than other hematological indexes in study.

Bacterial Infections↗
PubMedDate not supplied

Prepubertal rats are more resistant to ischemic renal injury and recover more rapidly than adult rats.

Bilateral clamping of renal pedicles during 60, 75 or 90 min was used to characterize the evolution of ischemic acute renal failure (ARF) in prepubertal rats. To verify the existence of age-conditioned differences in the evolution of ARF, adult rats were exposed to 40, 60 or 75 min of clamping. After 7 days, survival rate was significantly better in young than adult rats for identical times of clamping (89 vs. 35% for 60 min and 69 vs. 35% for 75 min). Young rats largely died within the first 24 h following ischemia while the risk of death extended until the 4th day after ischemia in adult rats. Peak values of serum urea nitrogen and creatinine were observed on the 1st and 3rd day after ischemia in young and adult rats, respectively. In young rats, these markers of renal function returned to normal on days 5 and 6 whereas they remained elevated at the end of the study in adult animals. Growth curves of young rats paralleled those of sham-operated animals from the 3rd day of clamping whereas adult rats did not even reach the initial weight at the end of the study. Analysis of kidneys obtained 7 days after clamping revealed more severe histopathological lesions in adult rats as well as a higher proliferative activity (10-40 times the value of sham-operated animals versus 2-4 times the control value in young rats). Our findings indicate that kidneys from young rats are more resistant to ischemia and recover more quickly from the ischemic insult. Therefore, the experimental model of ischemic ARF is clearly different in young and adult rats.

Acute Kidney Injury↗