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Biomedical subjects

F Saito

Publications and source records attributed to F Saito.

At least 145 records · Page 8Linked to original sources
PubMed1984

A pedigree of homozygous familial hyperalphalipoproteinemia.

A new form of familial lipoprotein disorder, homozygous hyperalphalipoproteinemia (HALP) was studied in one pedigree through three generations. The proband was a healthy male, 50 years old, who was checked for a distinctive elevation of plasma high-density lipoprotein cholesterol (HDL-C) in a routine screening examination. An intensive family study revealed that the proband and one of his sisters were homozygotic carriers of familial HALP judging by their extremely high concentration of HDL-C (181 mg/dL and 163 mg/dL, respectively). In the homozygotes, the lipid composition of HDL was found to be normal while the ratio of HDL lipids to apoproteins A-I and A-II tended to be increased. All five children of the two homozygous individuals and two additional first degree relatives were considered to be heterozygous, since their HDL-C values were moderately elevated, with other lipid levels being normal. The family study thus substantiated the hypothesis, as Glueck et al insisted in 1975, that this lipoprotein disorder is inherited by autosomal dominant transmission. Longevity analysis revealed that the decreased family members showed life prolongation of 9.8 years on an average compared with the appropriate control population of the same district. Our report might be the first to demonstrate the homozygous form of this longevity syndrome.

Adult↗
PubMed1983

Low density lipoprotein-sialic acids in patients with non-insulin dependent diabetes mellitus.

The important function of sialic acids in glycoproteins is to prolong the half life of the glycoproteins in the circulation. In this study, the sialic acid content of plasma low density lipoprotein (LDL)-apoproteins (predominantly B-100 apoprotein, a sialoglycoprotein) was analyzed together with relative electrophoretic mobility of LDL in 46 hypercholesterolemic and normo-cholesterolemic diabetics and non-diabetics. There was a significant positive correlation between the LDL-sialic acid content and LDL mobility either in the non-diabetics (r = 0.534, p less than 0.01) or in the diabetics (r = 0.482, p less than 0.02). Thus, the effect of the LDL-sialic acids upon the LDL electric charge was apparent. However, the LDL-sialic acids in the hypercholesterolemic diabetics were significantly (p less than 0.01) decreased to 9.64 +/- 0.63 micrograms/mg LDL protein (mean +/- S.E.) as compared with that in the normocholesterolemic diabetics (12.85 +/- 0.62 micrograms/mg LDL protein). Since the relatively sialic acid-poor LDL particles are rather accumulated in plasma of diabetic patients, the grade of sialylation of glycoprotein seems to have no role in the interaction with peripheral cells and therefore, the glycoprotein turnover, as far as the LDL apoproteins are concerned.

Adult↗
PubMed1983

[Effects of noradrenaline and isoproterenol on the insulin secretion from the rat pancreas perfused isolatedly in situ].

Effects of noradrenaline and isoproterenol on insulin secretion in rat pancreas have been studied by means of the in situ perfusion method described previously. Noradrenaline: The insulin secretion from the rat pancreas perfused with the high glucose buffer decreases after the administration of 1 microgram/0.1 ml of noradrenaline into the perfusion fluid. These noradrenaline-induced hyposecretions can be reversed by pretreatment with phentolamine (10 micrograms/ml), while they are potentiated after propranolol (10 micrograms/ml) pretreatment. Isoproterenol: The insulin secretion from the rat pancreas perfused with the same buffer increases after the administration of 1 microgram/0.1 ml of isoproterenol into the perfusion fluid. These isoproterenol-induced hypersecretions are found to be potentiated after pretreatment with phentolamine or propranolol, and atropine (100 micrograms/ml) pretreatment does not produce any changes in the isoproterenol-induced hypersecretion. These results suggest that the beta-receptors on the B-cells stimulate the insulin secretion and the beta-receptors on the D-cells decrease them. This communication gives a short discussion of whether alpha-receptors may be on D-cells or not.

Animals↗
PubMed1983

[Clinico-electroencephalographical significance of small sharp spikes].

Clinical and electroencephalographical investigations were made on the 234 patients with neuropsychiatric disorders, showing small sharp spikes (sss) on EEG. Incidence of sss was significantly higher in patients with epilepsy (8.6%) than in the non-epileptic cases (2.5%), especially in early age groups (11-35 years). Some differences in clinical features and in characteristics of sss were found between the epileptic patients and the non-epileptic patients; namely, 1) In majority of the subjects (97%), sss were observed exclusively in stage 1 and 2 of sleep, however, 8 epileptic patients exhibited sss in deep sleep (stage 3) or in awake state, as well as in light sleep. 2) In the non-epileptic group, females (3.4%) showed significantly higher incidence of sss than males (1.7%), while there was no sex difference in the epileptic group. 3) Of the non-epileptic patients, 45% had autonomic symptoms, such as headache, dizziness, tinnitus, nausea and vomiting, while there was no significant correlation between particular neuropsychiatric diagnosis and the EEG pattern. Among the non-epileptics, 72% showed normal EEG except for sss and in 89% sss appeared bilaterally but commonly bilaterally independently. 4) As to relation of sss to seizure types of epilepsy, complex partial seizures showed significantly higher incidence of sss (25.2%) than simple partial seizures (7.5%) and generalized tonic-clonic seizures (6.5%). In the patients with epilepsy, sss were often observed unilaterally predominantly (49%), especially in the patients with complex partial seizure (57%). In complex partial seizure, unilateral sss coincided with laterality of anterior-temporal seizure discharges in 68%. According to the results, the authors suggested that sss has some electroencephalographical significance, probably on mechanisms relating to epileptogenic dysfunction, particularly that of complex partial seizures.

Adolescent↗
PubMed1982

Apoprotein b-poor very low density lipoprotein in diabetic patients without hyperlipoproteinemia.

In order to see if there is a latent metabolic disorder of plasma very low density lipoprotein (VLDL) in uncontrolled diabetic patients without hyperlipoproteinemia, 28 diabetic patients and 13 matched normal subjects were analyzed for the compositions of fasting plasma VLDL. Although the lipid profiles and total apoproteins were similar among the normals, normolipoproteinemic well-controlled diabetics and normolipoproteinemic poorly-controlled diabetics, VLDL apoprotein B content tended to be decreased in poorly-controlled diabetics. Consequently, triglyceride/apoprotein B ratio was found to be increased significantly (p less than 0.02) to 12.5 +/- 1.3 (mean +/- S.E.) in the normolipoproteinemic poorly-controlled diabetics as compared with that in the normals (8.1 +/- 0.7). Since plasma VLDL is known to become relatively enriched with apoprotein B as the VLDL delipidation proceeds, the apoprotein B-poor VLDL in the normolipoproteinemic poorly-controlled diabetics seems to reflect a latent delayed turnover of circulating VLDL and this might be the disorder characteristic to diabetes mellitus.

Apolipoproteins↗
PubMed1981

[Insulin secretion in the perfusion of rat pancreas in situ (author's transl)].

A new perfusion technique was applied to the rat pancreas to elucidate neural mechanisms related to insulin secretion. The pancreas and a part of the gastroduodenal tract were perfused in situ with an artificial perfusion fluid consisting of 5% of rat blood cells, 4% bovine serum albumin and 0.1% of glucose and Krebs-Ringer bicarbonate buffer. Stimulation (5-10V, 5 msec, 50 Hz for 5 min) to the right or bilateral cervical vagal nerves produced a significant increase in insulin activity in the perfusate. Acetylcholine (5-10 micrograms/0.1 ml) added to the perfusion fluid produced a dose-dependent increase in insulin activity in the perfusate, and the responses disappeared after pretreatment with atropine (100 micrograms/ml in perfusion fluid). After adding noradrenaline or isoproterenol (each 0.1 micrograms/0.1 ml) to the perfusion fluid, appreciable changes were not apparent.

Acetylcholine↗
PubMed1977

[Initial EEG findings and the prognosis of epilepsy with generalized convulsive seizures].

Correlation between the initial EEG's and the prognosis of generalized convulsive seizures without other seizures was investigated. The subjects of this study was 437 epileptics with the period of the follow-up over 3 years. They were devided into 2 groups from view point of prognosis: "good prognosis" group, in which their seizures were completely controlled, the "poor prognosis", not well controlled. Most of the EEG findings appear to be not of value in predicting the prognosis. Exceptionally, however, the localized seizure discharged in the areas of T3,4, C3, 4 and P3,4 and 14--6 Hz positive spikes related closely to good prognosis, in the group of 7 to 12 years of the age.

Adolescent↗