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Biomedical subjects

F S Shofer

Publications and source records attributed to F S Shofer.

At least 55 records · Page 3Linked to original sources
PubMed1997

Transverse development of the jaws: norms for the posteroanterior cephalometric analysis.

Norms available for the posteroanterior (PA) cephalometric analysis yield different information. The material used to generate these standards is not clearly defined. The purpose of this study was to use data from the Bolton-Brush Growth Study to generate new norms for the PA analysis. The Bolton material is recognized as a controlled longitudinal record of growing children. The assumption that growth in the transverse dimension is the first to be completed is challenged by finding that increments in maxillary and mandibular width vary, like sagittal and vertical growth, according to gender and chronologic age.

Adolescent↗
PubMed1996

Identification of condylar anatomy affects the evaluation of mandibular growth: guidelines for accurate reporting and research.

Mandibular length is measured on cephalographs to depict changes during growth and after orthodontic treatment, and is often defined between condylion (Co, most posterior superior point on the condylar outline) and pogonion (Pog, most anterior point on the chin). The aim of this study was to assess the accuracy of identifying condylar anatomy, thus the validity of using Co-Pog to evaluate mandibular growth. The sample included 34 children from a prospective study on the early treatment of distoclusions. Two lateral head films were taken of each child, the first with the mouth closed (MC), the second with the mouth open (MO). Three examiners, two orthodontists (U.H. and K.H.) and a dental radiologist (R.B.), rated the condyle as identifiable, nonidentifiable, and interpreted. The rating was applied to the left (L) and right (R) condyles, or to only one outline (O) when the R and L structures appeared superimposed and were not distinguished separately. Besides Co-Pog, the orthodontists traced sella-nasion (SN) and incisor tip-menton (I-Me) to evaluate variability in measurements that do not include Co. One operator (J.G.) measured all distances. Agreement among the three examiners was best in rating the MO radiographs (50%): 4.1% identifiable, 5.9% nonidentifiable or interpreted; in the MC films, they agreed in 32.3% of the cases, but only one of the ratings was identifiable (2.9%). The highest agreement was in identifying the left condyle on the MO film (35.3%). Intraclass correlation coefficients for CO-Pog ranged from r = 0.73 (L side) to r = 0.92 (O) for one orthodontist, and for the other from r = 0.76 (O) to r = 0.85 (L). Both orthodontists had high correlations for SN and I-Me between MC and MO (0.94 < r < 0.98). The variability between examiners in recognizing condylar anatomy, particularly on radiographs taken with the mouth closed, suggests that the identification of condylar anatomy must be rated in studies of mandibular growth. Researchers measuring mandibular length in investigations of mandibular growth after orthodontic therapy should differentiate between cases where the condyle is readily identified, and those where condylar anatomy is interpreted.

Cephalometry↗
PubMed1996

Correlation of diet, other chewing activities and periodontal disease in North American client-owned dogs.

In 1350 client-owned dogs in North America, the association of calculus, gingival inflammation and periodontal bone loss with diet (dry food only, or other than dry food only), and with access to other chewing materials was analyzed. There were few apparent differences seen in dogs fed dry food only compared with those fed other than dry food only. There was progressively less accumulation of calculus, less gingival inflammation and less periodontal bone loss in dogs that were given access to more types of chewing materials (rawhides, bones, biscuits, chew toys) compared with dogs given access to fewer or no chewing materials. When the effects of individual chewing materials were analyzed, access to rawhides overall had the greatest apparent periodontal protective effect, and this effect was more apparent in dogs fed dry food only compared with those fed other than dry food only.

Animals↗
PubMed1995

Evaluation of risk factors for degenerative joint disease associated with hip dysplasia in dogs.

Passive coxofemoral joint laxity of dogs, as quantitated by a distraction-stress radiographic method, may have important prognostic value in determining susceptibility to hip dysplasia. Data from 151 dogs, representing 13 breeds, were included in a logistic regression model to evaluate the contribution of factors such as age, breed, weight, sex, distraction index, and Norberg angle to the risk of developing degenerative joint disease (DJD) of the coxofemoral joint. Of the factors studied, the amount of passive hip laxity, as quantitated by the distraction index, was the most significant (P < 0.0001) determinant of the risk to develop DJD of the coxofemoral joint. In the longitudinal and cross-sectional components of the study, distraction index was a significant (P < 0.001) risk factor for DJD, irrespective of age at evaluation (4, 12, or 24 months). The strength of the hip laxity:DJD correlation increased with the age of dog. In contrast, the Norberg angle, a measure of hip laxity on the standard hip-extended radiograph, was not found to be a significant risk factor for DJD, either in the longitudinal or cross-sectional analyses. Breed-specific probability curves of DJD susceptibility indicated that German Shepherd Dogs had a significantly (P < 0.05) greater risk of developing DJD than did the pool of non-German Shepherd Dogs. The information derived from this statistical model will help to scientifically characterize the role of passive hip laxity as a component in the pathogenesis of DJD of the coxofemoral joint.

Age Factors↗
PubMed1995

Comparison of susceptibility for hip dysplasia between Rottweilers and German shepherd dogs.

Passive laxity of the coxofemoral joints, as measured quantitatively by radiographing the joints under stress, has been shown to be an accurate measure of the risk for developing degenerative joint disease (DJD) of the coxofemoral joints. Seventy-four Rottweilers between 12 and 40 months old were evaluated subjectively for radiographic evidence of DJD, using the ventrodorsal view of the pelvis with the coxofemoral joints fully extended and the knees internally rotated (standard hip-extended view). Effect of age, sex, weight, and distraction index on the risk of developing DJD was evaluated by use of a logistic regression model. Results were compared with those from a group of German Shepherd Dogs. Results indicated that in Rottweilers the distraction index was the only statistically significant predictor of the risk of developing DJD of the coxofemoral joint. When German Shepherd Dogs were included in the model, they had a significantly greater risk of developing DJD than did Rottweilers. This finding provides further support for the theory that there are differences in disease susceptibility among breeds and emphasizes the need to develop disease susceptibility curves for all breeds affected by hip dysplasia to facilitate accurate, scientifically based recommendations for breeding or treatment.

Age Factors↗
PubMed1995

Effect of film-object distance on posteroanterior cephalometric measurements: suggestions for standardized cephalometric methods.

Posteroanterior (PA) cephalographs are used for diagnosis of transverse skeletal and dentoalveolar relationships. Unlike lateral head films, the variability of the PA radiograph has not been assessed. The purpose of this study was to evaluate the effect of film-object distance (film-ear rod, or film-porionic axis distance: FPD) and head angulation on transverse measurements from PA cephalographs. Seventeen skulls were selected from a total of 45 on the basis of strict criteria, including a stable reproducible centric occlusion. Radiographs were taken of each skull at the FPD of 11, 12, 13, and 14 cm. At the FPD of 11 and 14 cm, additional radiographs were taken at the angulations of +5 degrees and -5 degrees from the Frankfort horizontal (FH). Distances between the following landmarks were measured on the radiographs with digital calipers accurate to 0.01 mm: J (on the lateral contour of the maxilla), Ag (at the antegonial notch), Go (Gonion), Mb (buccal surface of mandibular first molar), IR (inner ramal point at the intersection of mandibular ramus and body). No clinically significant difference existed between measurements at the different FPDs evaluated. For this reason, and because the majority of PA films taken of 59 human subjects were within a FPD range below and including 13 cm, regression analyses were computed only at FPD = 13 cm. Correlation coefficients r between the distance AG-AG and distances J-J, IR-IR, and Mb-Mb were 0.71, 0.75, and 0.68, respectively. Transverse measurements were not significantly affected by a head angulation within 10 degrees (FH -5 degrees to +5 degrees).(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1995

Monitoring growth during orthodontic treatment.

The relationship between somatic growth and orthodontic treatment has been limited to the evaluation of body height and skeletal age relative to craniofacial development. The aim of this study was to evaluate the correlation of anthropometric and biochemical measures of general growth with facial and occlusal changes during the early treatment of Class II Division 1 malocclusion. Findings are reported from 46 children, ages 7.20 to 12.85 years (skeletal ages, 5.75 to 12.75 years), who are enrolled in a prospective clinical trial. Body and knee heights were measured monthly, with a Holtain stadiometer and a Knee Height Measuring Device, respectively. Every three months, serum levels were measured of the hormone dehydroepiandrosterone sulfate (DHEAS), an androgen associated with growth in midchildhood, and osteocalcin, an indicator of bone turnover. Significant correlations existed between knee height and various occlusal measurements, but mandibular length was not significantly correlated with knee height and DHEAS levels. Knee height correlated significantly (P < .05) with DHEAS and osteocalcin only in 46% and 37% of the children, respectively. The results indicate that the evaluated biochemical measures, at the time intervals considered, may not increase the accuracy of growth depiction by physical measures alone (height and skeletal maturation).

Anthropometry↗
PubMed1995

Antimicrobial susceptibility of subgingival bacterial flora in dogs with gingivitis.

The aerobic and anaerobic flora from gingival pockets of 49 dogs with severe gingivitis and periodontitis were cultured. The susceptibility of each isolate to four antimicrobial agents currently approved for veterinary use in the USA (amoxicillin-clavulanic acid; clindamycin; cefadroxil; and enrofloxacin) was determined. Amoxicillin-clavulanic acid (Clavamox Pfizer Animal Health) had the highest in-vitro susceptibility against all isolates (96%), all aerobes (94%) and all anaerobes (100%) tested. For gram-negative aerobes, enrofloxacin (Baytril, Bayer Corp.) had the highest in-vitro susceptibility activity. For bacteria associated with treatment of gingivitis, which typically are mixed aerobic/anaerobic and gram-positive/gram-negative organisms, the antimicrobial of choice for clinical use based on these susceptibility tests is amoxicillin-clavulanic acid.

Amoxicillin-Potassium Clavulanate Combination↗
PubMed1995

Antimicrobial susceptibility of subgingival bacterial flora in cats with gingivitis.

The aerobic and anaerobic flora from gingival pockets of 40 cats with established gingivitis were cultured. The susceptibility of each isolate to four antimicrobial agents currently approved for use in cats (amoxicillin-clavulanic acid; clindamycin; cefadroxil; enrofloxacin) was determined. Amoxicillin-clavulanic acid (Clavamox) had the highest in-vitro susceptibility against all isolates (92%) and all anaerobes (99% [co-equal with clindamycin]) tested; enrofloxacin (Baytril) had the highest in-vitro susceptibility against all aerobes (90%) tested.

Amoxicillin-Potassium Clavulanate Combination↗
PubMed1994

Comparison of fibrosarcomas that developed at vaccination sites and at nonvaccination sites in cats: 239 cases (1991-1992).

Questionnaires were sent to veterinarians who had submitted a fibrosarcoma from a cat to the surgical pathology services of the veterinary schools of the University of Pennsylvania and Tufts University between Jan 1, 1991 and June 30, 1992. Questionnaire items included signalment, FeLV and feline immunodeficiency virus status, site of sarcoma, vaccination site, vaccines used, treatment, biologic behavior of the tumor, and final outcome. Data were analyzed, using Student's t-test for continuous data, chi 2 test for categoric data, and log-rank test for survival estimates. Comparing results for cats with vaccination-site (VS) tumors and nonvaccination-site (NVS) tumors, we determined that VS tumors developed in younger cats and were larger than NVS tumors. Although VS sarcomas were biologically aggressive and redeveloped more often than NVS sarcomas, metastasis was not detected, and cats with VS tumors survived longer than cats with NVS tumors. Vaccination-site sarcomas developed in cats after injection of many types of vaccines, administered singularly or in combination. Of the cats in the VS group administered a single vaccine, 37% were given rabies, 33% were given feline viral rhinotracheitis/calicivirus/panleukopenia virus, and 30% were given FeLV vaccines. Cats with VS tumors were more likely to have received FeLV vaccine and less likely to have received rabies vaccine than those with NVS tumors. Although vaccines produced by certain manufacturers were used most often in cats with VS and NVS sarcomas, it was believed that this probably represented marketing practices and brand popularity.(ABSTRACT TRUNCATED AT 250 WORDS)

Adjuvants, Immunologic↗
PubMed1994

Changes of arch width in the early treatment of Class II, division 1 malocclusions.

Changes in arch width during the early correction of Class II, Division 1 malocclusions with either the Fränkel functional appliance or headgear are compared in an ongoing prospective randomized clinical trial. The data were collected from 43 children, ages 7.5 to 12.85 years, who met strict dental and cephalometric criteria for inclusion in the study. They were assigned at random to treatment with either a headgear (n = 21) or a Fränkel appliance (n = 22). Occlusal measurements included the maxillary and mandibular intermolar distances (buccal and palatal/lingual) and intercanine distances. Measurements (millimeters) were performed on casts taken every 2 months, with digital calipers accurate to 0.01 mm. Four months after the initiation of treatment, the mean maxillary intermolar distance was larger in the Fränkel group (palatal: 1.58, SE: 0.22; buccal: 1.58, SE: 0.20) than the headgear group (palatal: -0.39, SE: 0.21; buccal: 0.26, SE: 0.23), and the difference was statistically significant (palatal: p < 0.0001 and buccal: p = 0.0001). The mean maxillary intercanine distance increased more with the headgear (1.62, SE: 0.19) than the Fränkel appliance (0.62, SE: 0.23) p = 0.003. As treatment progressed, the average intermolar distance in the headgear group increased, but was still higher in the Fränkel group by more than 1 mm. The intercanine distance remained larger in the headgear group. The mandibular intermolar and intercanine distances were higher after Fränkel therapy than with headgear.(ABSTRACT TRUNCATED AT 250 WORDS)

Analysis of Variance↗
PubMed1994

Comparative histopathology of pemphigus foliaceus and superficial folliculitis in the dog.

A comparative histopathologic study of 50 cases of pemphigus foliaceus and 47 cases of superficial folliculitis in the dog was undertaken to identify those histopathologic features important in differentiating these diseases. All cases were diagnosed by the Surgical Pathology Service of the Laboratory of Pathology of the University of Pennsylvania, School of Veterinary Medicine, between January 1986 and March 1991. These cases were followed clinically to determine the accuracy of the initial histopathologic diagnosis. Data were analyzed by Fisher's exact test for discrete data and the Mann-Whitney U-test for continuous data. A probability of < 0.05 was considered statistically significant. The following breeds were affected with pemphigus foliaceus: Akita, Brittany Spaniel, Chow Chow, Collie, Dachshund, Doberman Pinscher, English Cocker Spaniel, English Setter, Golden Retriever, Siberian Husky, Laborador Retriever, Miniature Schnauzer, Old English Sheepdog, Scottish Terrier, Chinese Shar Pei, Spitz, Shetland Sheep Dog, Weimeraner, and West Highland White Terrier. An increased risk of developing pemphigus foliaceus was noted in the Akita (OR = 37.8), English Springer Spaniel (OR = 20.7), Chow Chow (OR = 12.3), Chinese Shar Pei (OR = 7.9), and Collie (OR = 3.9). Pemphigus foliaceus had a higher average density of acantholytic cells (226 +/- 22.9) than superficial folliculitis (11.8 +/- 4.6), and acantholytic cells were 183 times more likely to be present in pemphigus foliaceus. The presence of rafts of acantholytic cells occurred in pemphigus foliaceus (23/50) more often than superficial folliculitis (1/47). Recornification and reformation of pustules were, respectively, 13.4 and 3.6 times more likely to occur in pemphigus foliaceus.(ABSTRACT TRUNCATED AT 250 WORDS)

Acantholysis↗
PubMed1994

Association of age and body weight with periodontal disease in North American dogs.

Thirteen hundred and fifty dogs were examined under anesthesia at veterinary hospitals in the USA and Canada. Periodontal health was recorded in detail. Teeth were frequently absent (particularly lower third molar, upper and lower first premolars, and incisor teeth). Calculus was most extensive on the upper fourth premolar and molar teeth. Missing teeth, mobility of remaining teeth, extent of calculus and gingival inflammation, and furcation exposure and attachment loss all were more common in small dogs compared with larger dogs, and in order dogs compared with younger dogs.

Age Factors↗
PubMed1993

Idiopathic immune-mediated hemolytic anemia in dogs: 42 cases (1986-1990)

Forty-two cases of Coombs' positive or agglutinating immune-mediated hemolytic anemia (IMHA) in dogs were reviewed. Dogs ranged in age from 1 to 13 years, with a mean age of 6.4 +/- 3.4 years. The majority of dogs (74%) tested positive for IgG antibodies without complement. Spherocytosis was seen in 67% of the dogs, but hemoglobinemia and hemoglobinuria were found in only 10%. Marked bilirubinuria was found in all the dogs. A significant seasonal incidence was observed, with 40% of all cases diagnosed during the months of May and June. Severe anemia, with PCV < or = 20% was observed in 37 dogs (88%). Sixteen dogs (38%) had moderate to severe reticulocytosis and 12 dogs (29%) had mild reticulocytosis. Thus, the absence of reticulocytosis should not be used to rule out a diagnosis of IMHA. Concomitant mild to severe thrombocytopenia was observed in 28 dogs (67%). A mortality of 29% was observed during hospitalization. Risk of death was significantly increased in dogs without marked reticulocytosis, those with lower PCV, and dogs with serum bilirubin concentrations > or = 10 mg/dl. In severe cases of IMHA, rapid and aggressive supportive therapy is required.

Agglutination Tests↗
PubMed1992

Postvaccinal sarcomas in the cat: epidemiology and electron probe microanalytical identification of aluminum.

An increase in fibrosarcomas in a biopsy population of cats in the Pennsylvania area appears to be related to the increased vaccination of cats following enactment of a mandatory rabies vaccination law. The majority of fibrosarcomas arose in sites routinely used by veterinarians for vaccination, and 42 of 198 tumors were surrounded by lymphocytes and macrophages containing foreign material identical to that previously described in postvaccinal inflammatory injection site reactions. Some of the vaccines used have aluminum-based adjuvants, and macrophages surrounding three tumors contained aluminum oxide identified by electron probe microanalysis and imaged by energy-filtered electron microscopy. Persistence of inflammatory and immunological reactions associated with aluminum may predispose the cat to a derangement of its fibrous connective tissue repair response, leading to neoplasia.

Aluminum↗
PubMed1992

Preformatted charts improve documentation in the emergency department.

STUDY OBJECTIVES: To determine if the use of programmed charts with complaint-specific entry criteria results in improved documentation of patient encounters and better clinical outcome. DESIGN: Prospective study. SETTING: Emergency department of an urban university hospital. TYPE OF PARTICIPANTS: Female patients presenting to the emergency department with gynecologic complaints of abdominal pain, bleeding, or vaginal discharge. INTERVENTIONS: Programmed and blank charts were provided randomly for physicians in the ED. MEASUREMENTS: Chart scores based on documentation criteria for patient history, physical examination, laboratory studies, diagnosis, and discharge instructions and patient outcome scores of 0% to 100% based on the persistence of their complaints at the time of the follow-up interview. MAIN RESULTS: Overall documentation of history, physical examination, and laboratory studies was more complete on programmed charts than on blank charts (81.1% vs 71%, P less than .0001). The patient history portion of the charts was found to benefit the most from the use of programmed charts (74.8% vs 60.1%, P less than .0001). Although programmed charts demonstrated better documentation, there was no statistically significant correlation with patient outcome parameters or with patient satisfaction with the quality of medical care. However, more patients whose physicians used programmed charts were satisfied with their physicians' explanations of their problem (chi 2 = 5.2, P less than .02). CONCLUSION: Programmed charts improve documentation by facilitation of the documentation process and allow more time for patient-physician interaction. Quality of documentation alone, however, is not a reliable indicator of patient outcome or of the quality of care received.

Abdominal Pain↗