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Biomedical subjects

F S Mishkin

Publications and source records attributed to F S Mishkin.

At least 19 recordsLinked to original sources
PubMed1990

Application of nuclear medicine techniques to the study of ARDS.

Radionuclide techniques used for the diagnosis and study of ARDS include the routine clinical procedures of perfusion lung scanning, gallium and white-cell imaging, as well as PET, indicator dilution methods for measuring extravascular lung water, and means of measuring protein accumulation, protein flux, and solute transfer. The techniques that reflect the rate of protein leak from the microvasculature and sensitive measures of rapidly reversible alveolar injury appear most promising. While clinical usefulness remains to be documented, these methods may ultimately assist with the diagnosis of ARDS and with the evaluation of prognosis and therapy.

Humans↗
PubMed1979

Prognostic value of radionuclide angiography in cerebral vascular disease.

To ascertain the prognostic value of the radionuclide angiogram in ischemic cerebral vascular disease, we reviewed the results of this study in 2200 patients who underwent this procedure. The arterial phase showed decreased activity in 175 patients studied in detail during the acute phase of their neurologic illnesses. In the 120 patients who proved to have ischemic disease and persisting neurologic signs, two basic patterns appeared during the venous phase: (1) no increased (diminished or equal) perfusion, or (2) increased perfusion. Following the initial incident, the clinical course varied from no change to marked clinical improvement. In the first group with either diminished or equal venous perfusion, the chances against improvement are greater than 6:1. In the latter group the chances for improvement or deterioration are equal.

Arteries↗
PubMed1979

Angiotensin-I-converting enzyme and gallium scan in noninvasive evaluation of sarcoidosis.

Angiotensin-converting enzyme assays and gallium-scan results were obtained from 27 patients with biopsy-proven, clinically active sarcoidosis. Twenty-three of these patients had elevated converting enzyme levels, and 22 had positive gallium-scan results. Three of four patients with normal or borderline-elevated levels of angiotensin-converting enzyme also had positive gallium-scan results. Of 156 nonsarcoid patients (pulmonary and other diseases), 27 were found to have elevated serum converting enzyme levels, and 25 of these had negative gallium-scan results. These results indicate that the combination of an assay of angiotensin-converting enzyme and gallium scan increases diagnostic specificity from 83% to 99% without sacrificing sensitivity. We conclude that the concurrent use of angiotensin-converting enzyme assay and gallium scan is of value in the diagnosis of sarcoidosis.

Clinical Enzyme Tests↗
PubMed1978

Bone scans.

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Bone Neoplasms↗
PubMed1977

67Ga lung scan. An aid in the differential diagnosis of pulmonary embolism and pneumonitis.

Twenty-three patients patients with clinical signs of pulmonary embolic disease and lung infiltrates were studied to determine the value of gallium citrate Ga 67 lung scan in differentiating embolic from inflammatory lung disease. In 11 patients without angiographically proved embolism, only seven had corresponding ventilation-perfusion defects compatible with inflammatory disease. In seven of these 11 patients, the gallium 67 concentration indicated inflammatory disease. In the 12 patients with angiographically proved embolic disease, six had corresponding ventilation-perfusion defects compatible with inflammatory disease. None had an accumulation of 67Ga in the area of pulmonary infiltrate. Thus, ventilation-perfusion lung scans are of limited value when lung infiltrates are present. In contrast, the accumulation of 67Ga in the lung indicates an inflammatory process. Gallium imaging can help select those patients with lung infiltrates who need angiography.

Acute Disease↗
PubMed1977

Division of spermatic vessels in orchiopexy: radionuclide evidence of preservation of testicular circulation.

Satisfactory intrascrotal position of the testicles was achieved by dividing the spermatic vessels, leaving the vas deferens intact, in 3 patients with undescended testes. A postoperative scrotal scan provided objective means of evaluating the adequacy of testicular circulation. To determine the efficacy of various procedures for orchiopexy for undescended testes we suggest that postoperative evaluation include radionuclide imaging of the scrotum.

Adolescent↗
PubMed1977

Differential diagnostic features of the radionuclide scrotal image.

Differential diagnosis of scrotal lesions is aided by correlating radionuclide images with clinical findings. Subacute torsion is associated with peripheral hyperemia and can be mistaken for an inflammatory process; however, in a review of 128 studies, torsion and orchiectomy were the only processes encountered which had a center truly devoid of activity on the tissue phase compared to the normal side. Other lesions such as acute inflammation, abscess, hematoma, and hemorrhagic tumor may superficially appear to lack central activity but invariably contain at least as much activity when compared to the normal side.

Adolescent↗
PubMed1976

Direct recording on rectilinear scan images on 4x5-in. film.

Rectilinear scans are usually recorded on 14 X 17-in. x-ray film. This is costly both in terms of film and storage space. Using 4 X 5-in. film instead of the larger film will reduce this cost. An Ohio-Nuclear Model 84FD dual-probe 5-in. scanner was converted for the production of scan images directly on 4 X 5-in film (Kodak SO-79 nuclear medicine film). The smaller images may be viewed directly on a standard x-ray viewbox, or they may be projected if a larger image is desired. The image quality is excellent. This system has replaced the 14 X 17-in. film at our institution.

Photography↗