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Biomedical subjects

F S Brightbill

Publications and source records attributed to F S Brightbill.

At least 19 recordsLinked to original sources
PubMed2000

Outcome of corneal and laser astigmatic axis alignment in photoastigmatic refractive keratectomy.

PURPOSE: To compare the refractive results of laser astigmatic treatment in eyes in which the astigmatic axes of the eye and laser are aligned by limbal marking at the 6 o'clock position and in eyes that are not marked. SETTING: University Hospital and Clinics, Madison, Wisconsin, USA. METHODS: This retrospective study comprised 143 eyes that had photoastigmatic refractive keratectomy with the VISX Star excimer laser. The eyes were divided into marked (G1) and unmarked (G2) groups. Based on the preoperative astigmatism, each group was subdivided into low astigmatism (</=1.00 diopter [D]) and high astigmatism (>/=1.25 D). Early postoperative manifest refractions (1.0 to 2.5 months) were analyzed. The Alpins vector analysis method was used to calculate the target induced astigmatism, surgically induced astigmatism, difference vector (DV), magnitude of error (ME), angle of error (AE), and index of success (IS). RESULTS: There was no significant difference between the groups in DV, ME, and IS. When the subgroups were analyzed, the DV and ME were comparable; the IS in the G1 high astigmatism subgroup was significantly better than that in the G2 high astigmatism subgroup (0.22 +/- 0.08 and 0.29 +/- 0.04, respectively; P <.0001). There was comparable scatter of AE values; 30% and 36% in G1 and G2, respectively, had an AE of 0. Similar scatter was observed in the subgroups. Of the eyes that had an AE of 0, 90% and 43% in the high astigmatism subgroups of G1 and G2, respectively (P <.05), had full correction of astigmatism. CONCLUSION: Limbal marking and subsequent eye and laser astigmatic axis alignment improved the refractive outcome of laser astigmatic treatment of >/=1.25 D. A preliminary report of an ongoing prospective randomized study of eyes that had laser in situ keratomileusis is included.

Adult↗
PubMed1987

Recessive dystrophic epidermolysis bullosa.

Recessive epidermolysis bullosa dystrophica (REBD), a bullous disorder of the skin and mucous membranes, is frequently associated with ocular complications. A 40-year-old woman presented with lid ulcerations, chronic conjunctivitis, diffuse subepithelial corneal scarring, corneal ulceration, and cataracts. Management with intensive lubricant therapy, soft-bandage contact lenses, and cataract extraction successfully restored her sight. Histologic examination via light and electron microscopy revealed blister formation and scarring beneath the epithelial basement membrane of both the skin and cornea, confirming the diagnosis of REBD. The ultrastructure of the skin and cornea and the ocular complications of the major forms of epidermolysis are described herein. To our knowledge, successful ocular management of a confirmed case of REBD with complete ocular histopathologic features has not been documented.

Adult↗
PubMed1983

A comparison of intracapsular and extracapsular lens extraction combined with keratoplasty.

The clinical outcome and final visual acuities of 29 patients with intracapsular lens extraction and keratoplasty to 38 patients having extracapsular cataract extraction and keratoplasty were compared. Grafts remained clear in 89% of the intracapsular group and 82% of the extracapsular group over an average follow-up of 38 months and 21 months, respectively. Ninety-one percent of eyes with intracapsular lens extraction and 70% of eyes in the extracapsular group achieved a final visual acuity of 6/21 (20/70) or better. We found a significantly higher incidence of additional surgery in the extracapsular group and glaucoma in intracapsular combined cases. Late vitreous prolapse with vitreo-endothelial membrane formation and graft decompensation was a discouraging complication in three eyes having intracapsular extractions.

Adult↗
PubMed1981

A comparison of corneal storage in moist chamber and McCarey-Kaufman medium in human keratoplasty.

We examined the graft clarity and clinical outcome of 130 patients undergoing penetrating keratoplasty with donor preservation in either McCarey-Kaufman (MK) medium or moist chamber. We found comparable results with both methods of preservation in our two best prognostic groups. We feel MK medium is an excellent alternative to moist chamber preservation when used within 48 hours after the donor's death.

Adult↗
PubMed1980

Combined penetrating keratoplasty and mechanical anterior vitrectomy.

Forty patients with aphakic bullous keratopathy undergoing combined penetrating keratoplasty and anterior vitrectomy using mechanical vitreous instruments were studied for a mean length of 36 months. Seventy percent of the grafts remained clear and thirty percent failed during the follow-up period. Fifty-three percent of those with clear grafts (15/28) obtained a visual acuity of 20/70 or better. In comparison to older methods of anterior vitrectomy, we have found that removal of vitreous with mechanical vitreous instruments offers more effective removal of solid and liquid vitreous, decreased surgical time, and decreased retinal traction. Further, it is easy to learn to use and handle these instruments.

Corneal Diseases↗
PubMed1979

Corneal changes in aniridia.

Nineteen patients with aniridia and one patient with bilateral iris colobomata from eight families were examined for corneal abnormalities. Thirty-six eyes revealed changes that are consistent with a progressive corneal dystrophy. These changes begin in the corneal periphery in the early years of life and progress to the corneal center with increasing age. This dystrophy has been staged into four typical clinical patterns. Central corneal scarring, and in some cases, ulceration may occur, which may be a significant threat to vision.

Adolescent↗
PubMed1978

Postvitrectomy keratopathy.

Twenty-six of 75 eyes undergoing pars plana vitrectomy developed significant corneal complications requiring treatment. Slow or nonhealing epithelial abrasions, recurrent corneal erosion, and microcystoid and striate keratitis were among the most frequent problems. Significant predisposing factors included diabetes, surgical trauma such as epithelial debridement and prolonged operative time, aphakia, and postoperative glaucoma or hyphema. Corneal complications may be minimized with careful preoperative and operative precautions.

Adult↗
PubMed1976

Experimental studies with Staphylococcus aureus in M-K media.

This study reviewed the potential for survival of a pathogenic bacteria when inoculated into McCarey-Kaufman modified tissue culture media 199. A clinically isolated specimen of Staphylococcus aureus was selected and rabbit eyes inoculated with 0.1 ml. of the organism in a suspension of 1 to 3 x 10(-5). Upon enucleation 12 hours later no clinical signs of infection were noted. Limbal-conjunctival cultures were obtained on all eyes before and after application of the antibiotic. Corneas were stored in M-K media with standard penicillin-streptomycin added and cultured up to 48 hours. Our studies showed some recovery of the infecting organism from the media with topical antibiotic application but none following complete immersion of eyes in antibiotic. Direct cultures from corneal buttons taken 48 to 72 hours after antibiotic application by either method showed 1 to 3 colonies per plate in 25 per cent of eyes. In this study improperly applied antibiotic allowed some survival of S. aureus in the media.

Animals↗