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Biomedical subjects

F Rouillon

Publications and source records attributed to F Rouillon.

At least 55 records · Page 3Linked to original sources
PubMed1993

Prospective evaluation of the serotonin syndrome in depressed inpatients treated with clomipramine.

The serotonin syndrome, induced by serotoninergic agents, includes confusion, agitation, myoclonus, diaphoresis, tremor and diarrhea. The authors prospectively evaluated all these symptoms in 38 depressed inpatients fullfilling DSM-III-R criteria for major depression. Sixteen (42%) of 38 patients presented at least one symptom of serotonin syndrome. In 14 cases tremor and myoclonus occurred simultaneously, and 10 patients presented at the same time tremor plus myoclonus, diaphoresis and shivering. Except for 2 patients, symptoms were transient, lasted less than 1 week and disappeared with the pursuit of treatment.

Adult↗
PubMed1993

[Anxiety and depressive disorders in the postpartum period in pregnant females].

Several authors have found that caesarean section might be a risk factor for post-partum depression, while others consider that mood disturbances are not a specific response to delivery and can be observed in women undergoing hysterectomy. This longitudinal prospective study was carried out in 156 in-patient women at the Maternity department of Louis Mourier hospital, near Paris. These women were divided into three groups: 52 with normal delivery, 63 with caesarean section and 41 with gynecological surgery. Seventeen per cent of the women who had delivered suffered from baby-blues. The figure for anxiety (De Bonis scale > or = 20) was 23% in the 1st group, 41% in the 2nd group and 54% in the 3rd group. The figure for mood disturbances (according to DSM III criteria) was 4% in the 1st group, 16% in the 2nd group and 21% in the 3rd group. There was no significant difference between the 3 groups in figures for anxiety and depression during the first 3 months after delivery or surgery, but anxiety and depression ratings seem to fall faster and more steadily in women who had surgery.

Adult↗
PubMed1992

[Mental disorders in elderly hospitalized patients. Epidemiological study in an internal medicine department].

This epidemiological transversal study conducted on 100 patients older than 65 years hospitalized in the Internal Medicine department of a University hospital demonstrates the frequency of psychiatric pathology in these patients: dementia 19 percent; other psycho-organic disorders 17 percent; affective disorders 23 percent and other psychological disturbances 4 percent. Thus, 63 percent of this patient population had a mental disorder as defined by the DSM III criteria. These disorders are generally not or imperfectly identified by the internists in charge of these patients.

Aged↗
PubMed1992

Folates and post partum depression.

Hypofolatemia can cause psychiatric disturbances of a depressive nature. Pregnancy and delivery are often associated with hypofolatemia. This study was conducted to determine if hypofolatemia at day 3 post partum is a risk factor for baby blues or post partum depression. To study this hypothesis, 131 post partum women were followed prospectively for the 3 months immediately following delivery. 19% were found to have 'baby blues', as defined by a score greater than 20 on Pitt's scale (Pitt, 1968, J. Psychiatry 114, 1325-1335) and 12% had post partum depression as defined by a score greater than 7 on QD2A scale (Pichot et al., 1984, Rev. Psycholog. App. 34, 229-250, 323-340), within the three months post partum. No relationship was observed between the serum or erythrocyte folate levels on the third day following delivery and the maternal post partum depression scores. A statistically significant correlation between post partum depression and previous psychiatric disturbance was, however, observed.

Adult↗
PubMed1992

Neural symptoms induced by tricyclic antidepressants: phenomenology and pathophysiology.

The authors review the literature describing the neural symptoms induced by tricyclic antidepressants, especially tremor, seizures, akathisia, myoclonus, dyskinesia and delirium. Sedation, modifications of sleep, memory and appetite are also described. Tremor and myoclonus are the most frequent drug-induced neural symptoms. Delirium is most often caused by high-dosage treatments. The pathophysiology of akathisia and dyskinesia raises important questions concerning the mode of action of antidepressants.

Animals↗
PubMed1991

[Role of electroshock therapy in puerperal mental disorders].

Ten cases of psychotic patients requiring electroconvulsivotherapy (ECT) are reported during pregnancy and puerperium. The interest and the safety of ECT are confirmed. ECT is principally indicated in severe cases and in typical or atypical mood disorders.

Adult↗
PubMed1991

Prophylactic efficacy of maprotiline on unipolar depression relapse.

BACKGROUND: Although antidepressant medications have been in use for about 30 years, the question remains about their utility in the prophylaxis of recurrent depression. The purpose of this study was to evaluate the efficacy of maprotiline, a tetracyclic antidepressant, for depression prophylaxis. METHOD: We conducted a vast, prospective, multicenter, double-blind, placebo-controlled study of 1141 outpatients suffering from depression and treated with maprotiline or placebo for 1 year. The very large size of the study population allowed for the testing of two drug doses. The study design included a pre-inclusion treatment phase that assured that all study patients had recently suffered from a depressive episode and were in remission at the time they were randomized into two treatment groups (1 and 1/2 tablet of maprotiline 75 mg) and two control groups (1/2 and 1 tablet of placebo). RESULTS: The actuarial relapse rate at 1 year was 16% for maprotiline 75 mg, 1 tablet; 23.8% for maprotiline 75 mg, 1/2 tablet; 31.5% for 1 tablet placebo, and 37.5% for 1/2 tablet placebo. The difference between each group is statistically significant, except for the difference between the two placebo groups. The actuarial incidence of adverse drug reactions during the year was not statistically significant between the treatment and control groups. CONCLUSIONS: This study demonstrates maprotiline's prophylactic effectiveness for depressive relapses, the 75-mg dose being more effective than the 37.5-mg dose. The patients' tolerance of maprotiline therapy was satisfactory at both doses with prolonged prescription.

Adolescent↗
PubMed1988

[Study of the relation of gynecologic and obstetric findings and psychological disorders of pregnancy and the puerperium].

The relationship between gynaecological and obstetrical parameters and psychological troubles in pregnancy and after delivery are a matter of much debate. This arises partly because of different methods of studying the conditions and because of epidemiological studies that have been carried out on this subject. This longitudinal prospective study has been carried out on 211 women who were delivered in the maternity department of Louis Mourier Hospital. The figure for anxiety (in the de Bonis scale of greater than or equal to 20) was 13 to 15% at different times in the pregnancy, of depression (in the CESd scale greater than or equal to 16) was between 11 and 14.5%. 34.5% of those women who had delivered suffered from "baby blues", while 20% had symptoms of depression (CESd greater than or equal to 16 in the first week post-partum) and 6% had a quite obvious syndrome of depression (MADRS greater than or equal to 20). Finally, 18 to 24.5% of women had a major episode of depression (according to the DSM III test) in the year following delivery. As far as risk factors were concerned there was a statistically significant correlation between anxiety and depression in pregnancy and induction of labour, as well as difficulties with the third stage of labour and with an Apgar score of less than 9 in the infant. There was poor correlation between "baby blues" and gynaecological and pathological changes except where vaginal delivery was not spontaneous and where large episiotomies were carried out. On the other hand, women who had pathological labours or cesareans or a general anaesthetic for the third stage had more troubles than others in the year following delivery. Finally, women who showed signs of anxiety or depression in pregnancy or had "baby blues" after delivery were less likely to be able to breast feed their children.

Adult↗
PubMed1986

Diagnostic reliability among French psychiatrists using DSM-III criteria.

The reliability of French psychiatrists using DSM-III axis I disorders was studied using videotaped semi-structured diagnostic interviews, 136 psychiatrists with different levels of clinical experience classified 11 cases into six preselected diagnostic categories: Schizophrenia, Major Depressive Episode, Dysthymic Disorder, Cyclothymic Disorder, Other Psychiatric Diagnosis, No Present Psychiatric Diagnosis. A modified Kappa coefficient for multiple observers was used to calculate agreement and thereby estimate reliability. We obtained an overall Kappa of 0.55 for six categories, and when the Dysthymic and Cyclothymic Disorders were combined into one class, i.e. other specific affective disorders, the Kappa value increased to 0.64. The Kappa value for individual categories was best for Schizophrenia and Major Depressive Episode, and poor for Dysthymic and Cyclothymic Disorders. Clinical experience or prior knowledge of DSM-III criteria did not have a significant effect on reliability.

Adult↗
PubMed1984

[Plasma and saliva DST (dexamethasone suppression test) in depression. Clinical applications and kinetic approach].

Both plasmatic and salivary DST were simultaneously performed on a sample of 37 patients with a diagnosis of major depressive disorder (DMS III criteria): 22 primary depressions and 15 secondary depressions. Salivary DST showed a similar specificity but a decreased sensitivity in comparison with plasmatic DST. Essentially, the simultaneous use of both tests resulted in a better specificity for primary depression.

Adult↗
PubMed1981

[The nooanaleptics].

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Central Nervous System Stimulants↗