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Biomedical subjects

F Rosner

Publications and source records attributed to F Rosner.

At least 325 records · Page 18Linked to original sources
PubMed1975

In vitro combination chemotherapy demonstrating potentiation of vincristine cytotoxicity by prednisolone.

Human lymphoid cells grown in long-term tissue culture have been used to study the cytotoxic effects of the combination of vincristine and prednisolone. The potentiating effects of this drug combination in vitro cannot be consistently shown if the drugs are addeded without attention to the growth rate of the cultured population. If the cultured cells have achieved maximum density and have remained at this density for more than 24hr, they are readily killed by vincristine alone and no further kill is achieved by adding prednisolone. Rapidly growing cell cultures, however, are relatively ristant to vincristine. The addition of prednisolone to such cultures restores their sensitivity to vincriestine, but the combination is no more effective than is vincristine alone in stable cell populations. These findings indicate that the effects of vincristine on the mitotic spindle, which produce metaphase arrest, do not account entirely for its ability to destroy cells. A second mechanism of action of vincristine at low concentrations is proposed.

Cell Division↗
PubMed1975

Transient histiocytosis with striking phagocytosis of platelets, leukocytes, and erythrocytes.

Two cases of infection (miliary tuberculosis and a presumed viral infections) are described in which phagocytosis of erythrocytes, leukocytes, and platelets by reticuloendothelial cells was a prominent feature in bone marrow aspirates, associated with a clinical picture of fever, anemia, malaise, and hepatosplenomegaly. All these findings were "transient," and disappeared on treatment of the underlying infection.

Adult↗
PubMed1974

[Not Available].

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Bible↗