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Biomedical subjects

F Rodriguez

Publications and source records attributed to F Rodriguez.

At least 163 records · Page 9Linked to original sources
PubMed1983

Immunology of dermatophytosis. Experimental study.

By causing experimental lesions of dermatophytosis in rabbits inoculated and reinoculated with T. mentagrophytes var. granulosum and T. rubrum a study was carried out of the state of cellular immunity response, during infection, and also of the antigens responsible for the sensitization. Cellular immunity response was detected using the leucocyte migration test (L.M.T.) in the presence of antigenic compounds of the 'Keratinase' of Eleuterio et al.

Animals↗
PubMed1983

Glucagon and primary hyperlipidemias.

A reduction in glucagon secretion was found in a number of patients suffering from primary hyperlipidemias. This could be important in both the pathogenesis and classification of hyperlipidemias.

Glucagon↗
PubMed1982

Squamous cell carcinoma with sarcomatoid stroma.

Two cases of squamous cell carcinoma with sarcomatoid stroma are presented. One tumor was located in the soft palate that metastasized to a neck lymph node; the epithelial and the spindle cell component of the tumor at the primary as well as at the metastatic site showed ultrastructural features of squamous cell carcinoma. The other case, a laryngeal tumor with spindle cell stroma, was shown by ultrastructural studies to be composed of proliferating fibroblasts. The diagnostic problems and the controversies regarding classification and behavior of these rare tumors of upper respiratory tract and upper gastrointestinal tract are discussed.

Carcinoma↗
PubMed1982

Imide derivatives of 3-nitro-1.8-naphthalic acid: their inhibitory activity against DNA viruses.

The antiviral action of a new drug, 5-amino-2-(dimethylaminoethyl)-benzo-[de]-isoquinolin-1.3-dione has been studied against herpes simplex type 2 (HSV-2) and adenovirus type 5 (Ad-5) grown in Vero cells. The concentration of the drug which gives a 5 log10 reduction in virus titer was 4 micrograms/ml (maximum tolerated concentration) for HSV-2. The anti-HSV-2 activity of this compound was one log. more powerful than that of iododeoxyuridine (IDU). At this concentration the drug shows virucidal activity against HSV-2. No inhibition was found when the drug was tested against Ad-5. The inhibition of virus production has been studied depending upon the amount of drug or virus, and drug addition-time after infection. Reversibility of inhibition after drug removal, and drug resistance in the presence of the drug have also been determined.

Adenine↗
PubMed1982

Angiotensin II stimulates prolactin release in the rhesus monkey.

The effect of angiotensin II (AII) on plasma prolactin (PRL) concentrations was evaluated in ovariectomized rhesus monkeys which had been conditioned to chair restraining. Intracerebro-ventricular (i.v.t.) microinjections of AII increased PRL plasma levels in a dose-dependent manner. PRL values peaked at 10 min after injection and declined rapidly thereafter. Peak levels of PRL after 50 micrograms AII were approximately 7 times higher than those of baseline controls and were significantly reduced when 500 micrograms saralasin were injected via the ventricular route 15 min before AII injections. Measurements of vasopressin (AVP) plasma levels in some experiments showed that AVP release occurred following any dose of AII, irrespective of PRL liberation. In 2 animals, central injections of AII induced a dose-related increase in blood pressure. This study shows that, in primates, AII is able to influence PRL secretion via specific AII receptors. This action of AII is independent of AVP release and may be indirectly mediated through vasoactive effects of the octapeptide.

Angiotensin II↗
PubMed1981

[Experimental dermatomycosis, a clinico-pathological study].

Using rabbits, we have studied the effect of reinfection of T. mentagrophytes var granulosum and T. rubrum into lesions that were previously infected and resolved. Clinical mycological and histopathological studies were done for 16 weeks. Timentagrophytes produced a more severe infection than T. rubrum. The clinical lesions produced by reinoculation were less intense and long lasting.

Animals↗
PubMed1981

Sleep is not a prerequisite for the milk ejection reflex in the pig.

Electroencephalographic and electromyographic activities were recorded together with variations in intramammary pressure in unanaesthetized lactating sows during suckling. During each suckling period, milk ejection resulted in a sudden and brief rise in intramammary pressure. From the onset of suckling to the beginning of milk ejection, polygraphic recordings as well as observations of behaviour revealed that the sow was invariably in a state of arousal. This suggests that, unlike what has been proposed for the rat, sleep is not a necessary component of the milk ejection reflex in the pig.

Animals↗
PubMed1980

Evidence of a direct action of angiotensin II on neurones in the septum and in the medial preoptic area.

Angiotensin II (AII) was microiontophoretically applied on neurones located in the septum and the medial preoptic area (MPOA). All the septal neurones sensitive to AII (15/37) responded by an inhibition to the peptide application. Of 44 units tested in the MPOA 21 cells (48%) were sensitive to AII and responded either by an increase (11/21) or decrease (10/21) in their firing. The specificity of these responses were ascertained by simultaneous application of the antagonist Sar-Ile-Angiotensin II. These data suggest that Angiotensin II acts directly on neurones of the septum and medial preoptic area, structures implicated in the control of drinking behaviour.

1-Sarcosine-8-Isoleucine Angiotensin II↗
PubMed1979

Vasopressin release and drinking induced by intracranial injection of angiotensin II in monkey.

The effects of intracerebral injection of angiotensin II (AII) on both water intake and arginine-vasopressin (AVP) release were tested on unanesthetized rhesus monkeys (Macaca mulatta). Injection of 10(-10) mol of peptide was administered with a cannula microinjection system stereotaxically implanted into different diencephalic structures. The preoptic area, anterior part of third ventricle, caudate nucleus, and septum appeared to be the injection sites most effective in eliciting both drinking behavior and AVP release when the animal did not have access to water. On the contrary, when water was presented, AVP release was blocked after AII microinjections in the preoptic area and the third ventricle. No drinking was observed after microinjection in the supraopticus nucleus although AVP release was stimulated. These data suggest that AII might be effective in the regulation of water balance by centrally controlling both the input (drinking) and the output (ADH secretion) of water.

Angiotensin II↗