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Biomedical subjects

F Richard

Publications and source records attributed to F Richard.

At least 253 records · Page 14Linked to original sources
PubMed1980

Estramustine phosphate in the treatment of advanced prostatic cancer.

Thirty patients with advanced carcinoma of the prostate were treated with estramustine phosphate. All patients were followed up for a minimum of 9 months. Of 15 not previously treated with oestrogens 9 responded objectively and 11 subjectively. Of 15 patients whose tumours had failed to respond to at least 2 oestrogens, 3 responded objectively and 5 subjectively. Adverse effects consisted of cardiovascular complications, gynaecomastia and impotence. Gastrointestinal side effects were minimal and no hepatic, renal or marrow toxicity was seen. The criteria of assessment of response are discussed.

Estramustine↗
PubMed1980

Diagnosis and treatment of renal angiomyolipoma (based on 15 cases). Arguments in favor of conservative surgery (based on 8 cases).

Angiomyolipoma should be suspected when a renal tumor is present especially when the patient is young, the tumor is bilateral, associated with hemorrhagic incidents or if there are multiple tumors in one kidney. When tuberous sclerosis is present the diagnosis is easier and when it is not, arteriography and tomodensitometry are of great help. The benign nature of these tumors is not an argument in favor of nonsurgical treatment. They may sometimes be associated with an authentic malignancy which underlines the necessity of confirming the diagnosis by peroperative examination of a frozen section. When angiomyolipoma is confirmed the surgical treatment of this benign tumor should, in our opinion, be conservative considering the frequency of bilateral disease. This approach is supported by the results published and by our own 8 cases treated by conservative surgery.

Adult↗
PubMed1980

[Scanner examination of the kidney].

On the basis of a large series of documents, the authors participate in establishment of the classification of scanner appearances of urological diseases of the kidney : peripheral or parapelvic sub-capsular cysts, carcinomas and their spread, multiple tumours but of different nature in the same kidney, angiomyolipomas, polycystic disease, renal abscess, hydated cyst, non-invasive exploration of kidneys showed to be non-functioning by I.V.U., tumours of the intrarenal excretory system, lumbar trauma, long-term surveillance of the retroperitoneal space in individuals undergoing surgery for a urological malignant renoureteric tumour. The authors suggest a new chronological arrangement of investigations in the presence of a renal mass discovered by I.V.U. Scanner has its place between echotomography and renal arteriography. Investigations may be stopped at renal echotomography when this examination offers definite evidence of the fluid nature of the mass. Solid or doubtful nature of the mass necessitates the use of a scanner examination.

Abscess↗
PubMed1979

Etiological aspects and interest of early surgical management of priapism.

12 patients have been treated for priapism between March 1973 and September 1977. Etiologic conditions have been found 9 times, leaving only 3 idiopathic priapisms. Treatment of choice consisted of 8 saphenocavernous shunts, achieving detumescence in 7 cases and preserving sexual potency in 5. The precocity of operation seems of no interest to priapism itself but is mandatory to prevent secondary impotence.

Adult↗
PubMed1977

[1st cases of alpha-thalassemia in Algeria: 12 cases of hemoglobinosis H].

These first cases of hemoglobinosis H show that alpha-thalassemia is not a simple curiosity in this part of the Western Mediterranean. They are not localised to a single part of Algeria as the areas from which the patients came were more than 150 km apart. They suggest that the enquiry should be continued by other means to determine the prevalence and pathological incidence.

Adolescent↗
PubMed1977

[Clinical and biological aspects of beta-thalassemia. Apropos of 176 cases].

The study of 176 subjects with beta-thalassemia, associated or not with a hemoglobinopathy, shows great diversity. The hemoglobin C thalassemias are less severe and form a fairly homogeneous group. Sickle cell thalassemia cases have more marked anemia and the disease takes on more varied forms, no doubt because the main mechanism of the anemia, the hyperhemolysis, is influenced by several factors which have a variable effect on the clinical picture. Unassociated thalassemias seem the most polymorphic. Although it seems that in certain foci the beta-thalassemias are fairly stereotyped, this first study shows in Algeria great heterogeneity. All forms are observed both clinically and in the laboratory. Present classifications have not supplied a sufficiently operative model. It is not doubt necessary to await further progress in the laboratory to classify these diseases more precisely.

Adolescent↗
PubMed1977

Phenotypic variation in red cell G-6PD deficiency in heterozygotes.

Erythrocyte G-6PD activity in 69 heterozygotes has a log-normal distribution, a fact which cannot be solely attributed to random X chromosome inactivation. Others factors - genetic and individual - are suggested by intrafamilial clusting and post-natal variability of phenotype.

Erythrocytes↗