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Biomedical subjects

F Richard

Publications and source records attributed to F Richard.

At least 217 records · Page 12Linked to original sources

[Magnetic resonance imaging of pelvic tumors in men. Preliminary results in a series of 28 patients].

The authors conducted a retrospective evaluation of the diagnostic value of nuclear magnetic resonance in comparison with other imaging techniques in a series of 28 pelvic tumours, with the exclusion of gastrointestinal tumours. The positive diagnosis of the lesion was obtained in every case. The variation of the signal provided information concerning the tissues, while the sections in three planes, the spontaneous visibility of the vessels and the very good natural contrast related to the presence of fat which gives a high signal, facilitated staging of the tumour.

Bone Neoplasms↗

[Neuroanatomical study of micturition].

There are three superimposed centres of micturition: the sacral spinal centre, which is the oldest centre controlled by the pontine centre situated in the brain stem, which in turn is under the control of multiple subconscious structures: cerebellum, striate nucleus, hypothalamus and conscious structures: limbic cortex, frontal ascending and parietal ascending circumduction. The nervous pathways consist of the classical spinal pathways as far as their point of emergence. The innervation involves 2 systems:--a supra-levator system consisting of the essentially sympathetic superior hypogastric plexus and the essentially parasympathetic inferior hypogastric plexus which innervates the seminal tract, the bladder and the prostatic urethra;--a infra-levator system consisting of the internal pudendal nerve which innervates the striated sphincter.

Humans↗

[Treatment of neoplastic thromboses of the inferior vena cava secondary to adenocarcinomas of the kidney. Study of 40 cases].

The extension of renal cell cancer into the vena cava is not inaccessible to treatment. In the absence of any other effective treatment, only surgical resection is able to provide a chance of long term survival. The authors report their experience of 40 cases, 24 of which underwent complete resection of their lesions. The survival rates in these cases were 47.6% at 1 year, 28.6% at 2 years, 15% at 3 years and 9.5% at 5 and 7 years. A selective approach to the right auricle was performed in three patients and the technique of this operation is outlined. The global mortality was 8.8%. The various technical possibilities and the prognostic factors are also reviewed.

Adenocarcinoma↗

Current results of neutron therapy at the UCL, for soft tissue sarcomas and prostatic adenocarcinomas. Université Catholique de Louvain.

From March 1978 to August 1985, 630 patients were treated with fast neutrons at the UCL cyclotron of Louvain-la-Neuve. Neutrons are produced by bombarding a beryllium target with 65 MeV protons. A CNPF of 2.8 was adopted. As far as soft tissue sarcomas are concerned, 32 patients were irradiated after "radical" surgery: only 2 local recurrences were observed (follow-up from 6 months to more that 5 years). On the other hand, in a group of 26 patients with large inoperable, recurrent of incompletely resected tumours, local control could not be achieved in 14 cases. In the whole group of these 58 patients, 12 severe complications were observed; their frequency increases with field size which in turn reflects tumour extent. Locally extended prostatic adenocarcinomas (stage C) were treated with mixed schedule irradiation (3 neutron and 2 photon fractions per week). A local control rate of 93% at 1 year, of 83% at 2 years, and 90% at 3 years was achieved (28, 23 and 10 patients respectively). The early and late tolerance was excellent; only one complication was observed.

Adenocarcinoma↗

Postconception menses induction using prostaglandin vaginal suppositories.

Vaginal suppositories containing 15 methyl prostaglandin F2 alpha methyl ester in a high-melt base were administered to 60 women desiring early pregnancy interruption who were no more than 56 days' (eight weeks) pregnant as calculated from the first day of the last regular menstrual period (LMP). The purpose of this study was to evaluate the safety, efficacy, and patient acceptability of this mode of noninvasive early abortion. Some factors evaluated during the study included the time interval from insertion of the suppository to the onset of cramping and bleeding. Also measured were immediate and delayed blood loss, nausea, vomiting, and diarrhea. Of the 60 patients entered into the study, 55 procedures have been judged as successful by the prospective criteria set forth in the protocol. There were no deaths or serious complications. Four patients required hospitalization and follow-up dilatation and curettage (D&C). One patient withdrew from the study after receiving a suppository and subsequently delivered a preterm infant.

Abortion, Induced↗

Results of neutron therapy of locally advanced soft tissue sarcomas at Louvain-la-Neuve.

Between March 1978 and October 1983, 65 patients with locally advanced soft tissue sarcomas were treated at the cyclotron of Louvain-la-Neuve. 46 patients are analysed, 19 patients with intraabdominal or intrathoracic lesions are excluded. After "radical surgery" (no "gross tumour" present at the time of neutron therapy), a local control rate of 93% was achieved (25/27 patients) and the survival was 74%. In a second group of 19 patients with incompletely resected, or recurrent, or inoperable tumour, a local control was obtained in four cases (21%), and 13 patients were alive (69%). The follow-up ranged from three to 65 months (mean: 25,9 months). Ten severe complications were observed (22%); they were related to the field sizes, which reflected the local tumour extent.

Belgium↗

Local recurrence after nephrectomy for primary renal cancer: computerized tomography recognition.

We diagnosed by computerized tomography 15 local recurrences in 88 patients who had undergone nephrectomy for renal cancer, with no false positives and 1 false negative. This over-all low rate (17 per cent) probably is owing to the fact that computerized tomography scans were done in patients in good clinical condition. Local recurrence was noted in 3 of 59 asymptomatic patients and in 12 of 19 patients with local symptoms. No recurrence was noted in 10 patients with general symptoms. Thus, 20 per cent of local recurrences were asymptomatic and 80 per cent presented with local symptoms. High local recurrence rates were found in cases of transitional cell carcinoma with whole wall involvement or extension to adjacent tissues (4 of 8 patients, 50 per cent), clear cell adenocarcinoma with lymph node involvement (3 of 7 patients, 43 per cent) and partial nephrectomy (3 of 6 patients, 50 per cent). Therefore, we consider such patients to be at high risk. Our study demonstrates that computerized tomography enables earlier, accurate diagnosis of smaller local recurrence in asymptomatic patients and provides a sensitive, reliable, noninvasive, repetitive method of evaluation of clinical treatment trials. Routine followup should be reserved for high risk patients.

Adenocarcinoma↗

Short-term prophylaxis with cefotaxime in prostatic surgery.

During a 20 month period 167 patients undergoing transurethral resection of prostate were divided into two groups: a control group without prophylactic antibiotics and a treated group who received cefotaxime 3 g intravenously perioperatively. In the first seven post-operative days 50 patients in the control group had a urinary tract infection (greater than 10(5) cfu/ml) compared with 14 patients in the treated group (P less than 0.0001). Two blood cultures were positive, both in the controls. A full course of antibiotics was administered to 55 in the control group and 14 in the treated group. On the thirtieth post-operative day 24 patients had urinary infection in the control group compared with 5 in the treated group (P less than 0.0001). We conclude that this short-term prophylaxis with cefotaxime significantly reduced the rate of urinary infection after transurethral prostatectomy.

Aged↗

[Treatment of primary vesico-renal reflux in adults. Apropos of 40 patients].

The authors report a series of forty patients presenting with vesicorenal reflux treated by ureteral reimplantation. Seventeen ureterorenal units were treated by Hutch's procedure, with a success rate of 75%. In 1972, this procedure was abandoned in favor of Cohen's technique, and a further forty two ureterorenal units were treated with a 90% success rate. There was no recurrence of the reflux, but there was one case of stenosis.

Adult↗