Search PubMed⌕ Search

Biomedical subjects

F Revenga

Publications and source records attributed to F Revenga.

15 recordsLinked to original sources

Primary cutaneous cryptococcosis in an immunocompetent host: case report and review of the literature.

We report a 46-year-old male who developed cellulitis of his third right finger after being injured with a metallic object. Cryptococcus neoformans var. neoformans was isolated from both the skin and the metallic object. Systemic cryptococcosis and immunosuppression was excluded by appropriate tests. Complete healing was achieved after 10 months of itraconazole 100 mg/12 h and surgical excision of the remaining lesion. Our literature review shows another 16 cases of primary cutaneous cryptococcosis in nonimmunocompromised hosts. The clinical, mycological and therapeutic characteristics of these patients are reviewed.

Antifungal Agents↗

Facial orf.

Explore the source record for details and available documents.

Adult↗

Cryofibrinogenaemia with a good response to stanozolol.

We report a 63-year-old patient with an IgA-kappa multiple myeloma in complete remission who developed necrotic lesions on both ears and papular, purpuric lesions on his legs and cheeks. Initial differential diagnosis included perniosis and skin necrosis secondary to interferon treatment but subsequent investigation revealed cryofibrinogenaemia as the underlying cause. Stanozolol therapy, 2 mg/12 h, achieved a complete clearance of the skin lesions. Cryofibrinogenaemia is a disease which can be under-diagnosed unless it is considered in the work-up of a patient with thrombotic skin lesions. Stanozolol is useful as first line therapy for this disorder.

Anabolic Agents↗

Cutaneous Alternaria alternata infection successfully treated with itraconazole.

A case of cutaneous alternariosis due to Alternaria alternata in a 47-year-old man who had the CREST (calcinosis, Raynaud's phenomenon, oesophageal dysfunction, sclerodactyly and telangiectasia) syndrome with pulmonary hypertension is presented. The patient, who lived in a rural area and was receiving prostacycline by continuous infusion, prednisone and azathioprine for his underlying disease, showed cutaneous lesions of the lower extremities spreading from the knees to the ankles. The patient was successfully treated with high doses of oral itraconazole.

Alternaria↗

Multiple cutaneous sensitization to nonsteroidal anti-inflammatory drugs.

The use of topical nonsteroidal anti-inflammatory drugs is widespread (particularly in countries bordering the Mediterranean). Compared to their wide use, the incidence of published adverse cutaneous effects appears minimal, although they are increasing. Most of them are a form of allergic contact dermatitis (ACD). Multiple sensitization and/or cross-reactions are rarely reported. Interestingly, our patient presented ACD with diclofenac and etofenamate (both from different chemical groups) and, furthermore, patch tests were positive with bencydamine and indomethacin (both indolacetic acid derivatives), piroxicam and fepradinol. We think that our results could not be explained due to cross-reactivity, and that multiple sensitization was more likely.

Adult↗

Annular elastolytic giant cell granuloma--actinic granuloma?

A 56-year-old woman with annular elastolytic giant cell granuloma is reported. She had annular, slowly growing lesions on sun-exposed areas and the dorsum of one foot. Biopsies from both areas revealed a mid-dermal inflammatory infiltrate with many giant cells engulfing elastic fibres. The current nosological situation of this process is discussed. Actinic granuloma (AG) is a term coined by O'Brien in 1975 to describe a cutaneous process characterized by multiple annular lesions located on sun-exposed skin areas. The histopathology is defined by the presence of multinucleated giant cells containing elastic fibres at the lesion edge, and the absence of these fibres at the lesion centre. The nosology of this disease and the role of actinic exposure as a triggering factor for it has been much discussed in recent years. We report a new case of AG not limited to photo-exposed areas.

Female↗

Epidemiologic study of contact dermatitis in hemodialysis patients.

Hemodialysis (H) implies the application of different topical substances (such as antiseptics, plaster and rubber chemicals, etc.) and the contact with potential allergenic materials (like gloves, catheters, needles, etc.). H patients may present contact dermatitis (allergic or irritant) as a consequence of this procedure. The frequency of this dermatitis is not known, as reports of isolated cases constitute the only source of information. The aim of this study was to evaluate the prevalence of contact dermatitis and positive patch tests (PT) in patients treated with chronic maintenance H. Eighty patients (40 females and 40 males) on chronic H were studied. We found a low frequency of eczematous lesions among our H patients (1.25%). PT were carried out with the GEIDC standard panel and a "dialysis" battery. Fourteen patients (17.5%) had positive PT, 3 of them having polysensitization. The most frequent sensitizing agents were p-phenylenediamine (3.75%), carba mix (3.75%) and Betadine solution (3.75%). Irritative patch test reactions were seen in 29 patients (36.2%), all of them due to Betadine solution (povidone-iodine). There was no relationship between the length of time of H, sex, age, history of contact dermatitis or cutaneous examination for dermatitis, and PT results. Regarding our results one might suggest that H is a low source of sensitization, but one has to take into account the state of anergy typical of uremic patients. Although the H procedure could be responsible for those sensitizations, it is also possible that they were acquired before H treatment.

Adult↗