Search PubMed⌕ Search

Biomedical subjects

F Rengo

Publications and source records attributed to F Rengo.

At least 163 records · Page 9Linked to original sources
PubMed1981

[Effects of guaiacolic ester of acetylsalicylic acid on spirometric and plethysmographic parameters in subjects with chronic obstructive bronchopneumopathy].

The effects of oral administration of guaiacolic ester of acetyl salicilic acid in 24 patients with chronic obstructive lung disease have been evaluated. 1.5 g of this drug were given daily into 3 administrations improving both objective and subjective symptomatology in 19 of the 24 patients after 1 or 3 weeks of treatment. Moreover, a statistically significant improvement of FEV 1" (p less than 0.001), Raw (p less than 0.005) and FEV 1"/VC (p less than 0.01) was observed. The remaining 5 patients discontinued the treatment failing the improvement of the subjective symptomatology.

Aged↗
PubMed1981

The reflex control of arginine-vasopressin release in essential hypertension.

1. The reflex control of arginine-vasopressin release was studied in 12 essential established hypertensive patients and in 12 age-matched normal subjects by comparing the effects of head-up tilt and a variable-pressure neck-chamber. 2. After 45 min 85 degrees head-up tilt, normal subjects showed an increase in plasma arginine-vasopressin and in plasma renin activity, while plasma volume decreased. In hypertensive patients, plasma arginine-vasopressin showed changes after tilt opposite to those of controls, while the changes in plasma renin activity and plasma volume were similar to those observed in the normal group. In both groups the changes in systolic and diastolic blood pressure were not statistically significant. A reduction in carotid sinus transmural pressure obtained by increasing neck-tissue pressure (+50 mmHg) by means of a neck-chamber, evoked different responses in mean blood pressure in the two groups, but failed to induce any significant change in plasma arginine-vasopressin concentration both in the normal and in the hypertensive subjects. 3. These results seem to suggest that carotid sinus baroreceptors, though active in blood pressure control, do not play a direct role in arginine-vasopressin release and, therefore, the opposite response of arginine-vasopressin observed after tilt in the two groups of subjects should be ascribed to more complex mechanisms.

Adolescent↗
PubMed1981

Baroreflex responsiveness in borderline hypertensives: a study with neostigmine.

The baroreflex response to changes in transmural pressure throughout the arterial tree or limited to the carotid sinus was evaluated in ten borderline hypertensives and compared with that observed in ten normal subjects and in ten established hypertensives. Baroreceptor sensitivity was tested by evaluating both heart rate response to phenylephrine-induced increase in arterial pressure and heart rate and blood pressure changes induced by increased neck tissue pressure by means of a neck chamber. The heart rate response to phenylephrine (evaluated by the regression of the R-R interval versus the systolic blood pressure) was depressed both in borderline and established hypertensives as compared with controls. Similarly, the heart rate and the pressor response to increased neck tissue pressure were depressed in both groups of hypertensives. In borderline, but not in established hypertensives, neostigmine administration improved consistently the pressor baroreflex response to increased neck tissue pressure and the heart rate reflex response to both the employed stimuli. These findings indicate that a reduced parasympathetic activity is one of the components involved in the altered baroreflex sensitivity in borderline hypertensives.

Adult↗
PubMed1981

Comparison of the antihypertensive activities of xipamide and chlorthalidone: a double-blind, randomized, crossover trial.

The effectiveness of a new potent diuretic, xipamide, was evaluated in the treatment of patients with mild to moderate essential hypertension. The effects of daily doses of 40 mg xipamide were compared with those of 100 mg chlorthalidone with respect to systolic and diastolic blood pressure, using a double-blind crossover design. Patients received each drug for 6 weeks, the order of treatments being at random and the periods being separated by a 'washout' period of 7 days. The results showed that xipamide was as effective as chlorthalidone in controlling blood pressure, both in the upright and supine positions, and when administered after chlorthalidone produced a further reduction. No such further reduction occurred when chlorthalidone was given after xipamide. Serum electrolyte changes induced by the two diuretics were comparable. Both drugs were well tolerated and caused few side-effects.

Adult↗
PubMed1981

Mechanisms underlying systemic hemodynamic responses to experimental coronary artery occlusion. A preliminary study with hexamethonium.

The hemodynamic changes induced by coronary occlusion were investigated in anesthetized dogs. Coronary occlusion elicited an immediate but transient increase in the systemic blood pressure and in the vascular resistance of the hind limb perfused at constant flow. Thereafter, systemic hypotension and vasodilatation in the perfused region were observed. Vagotomy abolished the initial increase of the systemic and perfusion pressure and reduced significantly the late vasodilator response both systemically and in the perfused hind limb. After the subsequent administration of hexamethonium the vasodilatation in the hind limb was no longer manifest but the fall in blood pressure was unmodified. These results seem to suggest that multiple mechanisms are involved in the hemodynamic response to coronary occlusion.

Animals↗
PubMed1981

[The vectorcardiogram pattern of the athlete's heart (author's transl)].

In order to assess the vectorcardiographic pattern of the athlete's heart, we evaluated the vectorcardiograms of 17 professional footballers; the signs of ventricular hypertrophy were particularly studied. 9 athletes had left ventricular hypertrophy, 3 showed VCgraphic signs of combined ventricular hypertrophy and 5 had normal vectorcardiograms. In all athletes with left ventricular hypertrophy the initial forces had normal spatial orientation (I A left ventricular hypertrophy). Likely, the combined right ventricular hypertrophy explains these VCgraphic patterns. The QRS loop did not show abnormal morphology, only the high magnitude of the spatial maximum QRS vectors was significant for diagnosis of left ventricular hypertrophy. The increase of the cardiac volumes induced by training might explain the high magnitude of the QRS loop.

Adult↗
PubMed1981

[Serial evaluation by effort test of the effects of coronary artery bypass on effort angina (author's transl)].

To evaluate the duration of favourable effects of coronary artery bypass (CAB) on exercise-induced angina (A), 58 patients: 13 with single 21 with double and 24 with triple vessel disease, were studied. All patients underwent CAB for stable angina on effort. Patients underwent exercise testing (ET) before surgery at one, two and three years. Heart rate peak (HR), HR x systolic blood pressure peak (DP), work load (W), exercise-induced ST segment depression (ST) and incidence of A were evaluated; the results of ET before surgery were compared with those found after CAB. Our findings show that HR, DP, W and ST were significantly improved by surgery for at least 3 years. The lowest incidence of A was found at one year ET (20.6%), while it increased at two years (27,5%) and three years ET (37.9%). Most patients with A had angiographic evidence of left ventricular abnormal wall motion and ec-graphic signs of previous myocardial infarction. Our data indicate that serial exercise testing can objectively monitor the results of CAB. Most patients show an improved exercise tolerance for up to 3 years after CAB. Some patients, with more extensive CAD, showed a progressive deterioration of the clinical pattern and a decrease of the exercise tolerance.

Angina Pectoris↗
PubMed1981

[Influence of left ventricular volume changes induced by Valsalva maneuver on R wave amplitude (author's transl)].

Exercise-induced changes of R wave amplitude (delta R) during exercise has been employed to improve the reliability of stress testing in detecting patients with coronary artery disease. Several authors postulated that delta R are related to changes of ventricular volumes. Furthermore Valsalva Maneuver (VM) is able to induce a decrease of left ventricular volumes induced by VM and the variations of R wave. Echocardiographic method was used to determine left ventricular volumes and R wave amplitude changes were evaluated by Frank's lead. Our findings suggest that R wave amplitude changes are not related to variations of cardiac volume. Electrophysiological mechanisms of delta R need further investigation.

Adolescent↗
PubMed1981

[The hemodynamic effects of reproterol in patients with chronic obstructive lung disease (author's transl)].

Our study was undertaken in order to evaluate hemodynamic effects of intravenous administration of Reproterol in patients with chronic obstructive lung disease (COLD). Reproterol is a monomulecolar combination of catecholamine and theophilline. Diastolic pulmonary pressure and wedge pressure decreased 20 minutes after Reproterol while total pulmonary resistances were reduced 10 minutes after drug administration; sistolic pulmonary pressure and cardiac index increased only after 10 minutes; heart rate increased until 15th minute. Reproterol, as a catecholamine-theophylline combination, has an additional site of action over and above the pure catecholamine effect owing to inhibition of phosphodiesterase; so an increase in cAMP content is achieved either by increasing the synthesis or by blocking the breakdown. Our results assess that Reproterol has a beneficial effect on pulmonary hemodynamics in COLD.

Adult↗
PubMed1980

Exercise tolerance as evidence of quality of life in CAD patients after coronary artery bypass by comparison with medical treatment.

The effects of coronary artery bypass (CAB) by comparison with medical treatment were evaluated on exercise tolerance in 68 patients with stable angina on effort, who underwent coronary and left ventricular cineangiography. Stress tests were performed by bicycle ergometer before medical and surgical treatment, and 6 and 12 months thereafter. Thirty-five patients (31 males and 4 females; 7 with one 70% stenosed vessel, 12 with two, 16 with three) underwent CAB; 33 (30 males and 3 females; 9 with one 70% stenosed vessel, 11 with two, 13 with three), having refused CAB, only underwent medical treatment. Both groups were given long-acting oral nitrates, none received digitalis and/or propranolol; antiarrhythmic drugs were only administered in 5% of medical and 4% of surgical patients. Both groups at 6 and 12 months follow-up showed a significant improvement in exercise tolerance. Surgical patients showed a significant increase in exercise tolerance with lower angina incidence (from the preoperative 100% to 26% and 22%, respectively), higher work load (P < .001), and a significant reduction of S-T segment depression (P < .001). Medical treatment induced an increase of exercise tolerance; angina on effort decreased (from 100% to 74% and 72%, respectively) with higher work load, and a significant reduction of S T depression (in both cases P < .001). Comparing the data of the two groups, we observed that surgical patients showed higher exercise tolerance (P < .01), lower S-T depression (P < .001) and angina incidence. Our results suggest that surgical treatment is able to improve exercise tolerance more remarkably than medical treatment.

Adult↗