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Biomedical subjects

F Regoli

Publications and source records attributed to F Regoli.

At least 37 records · Page 2Linked to original sources
PubMed1981

[Dilazep vs. nifedipine in patients with stable effort angina. A double blind randomized study (author's transl)].

In a randomized double-blind study the activity of dilazep (D) vs. nifedipine (N) was evaluated in 50 outpatients with effort angina; 26 were treated with dilazep 300 mg/die and 24 with nifedipine 30 mg/die. The observation period lasted 30 days. Before and at the end of treatment were evaluated: ECG, basal and during hyperventilation test, ergometric test, BP, HR, DP, ST depression, arrhythmias, maximum tolerated and total work done, number of anginal attacks and side effects. In 19 symptomatic subjects (D), weekly anginal crises were reduced (p less than 0.001) with normalization of 6 patients (31.6%). In group N a reduction (p less than 0.001) of anginal crises/weeks was recorded with normalization in 3 subjects out of 14 symptomatic (21.4%). In both groups ST depression was significantly (p less than 0.001) reduced. ECG during exercise normalized in 9 patients (34.6%) of D group and in 5 (20.9%) of N group. Total work performed increased after treatment in both groups. 13 patients of group D complained 19 side effects, all of short duration, whereas 54.2% (13 subjects) of group N complained 25 side effects 13 of which (52%) of short duration and 12 (48%) persistent. The results obtained pointed out a superimposable therapeutic efficacy of the two drugs, but dilazep was better tolerated.

Aged↗
PubMed1981

[Exercise tolerance in angina patients 3 and 24 hours after administration of a new delayed-action preparation of metoprolol].

To assess the duration of improved exercise tolerance by metoprolol given in a new sustained-release formulation, 40 in-patients affected by stable exercise-induced angina pectoris received single-blind placebo in day 1 and thereafter, in double-blind cross-over once daily administration, metoprolol RETARD 100 mg and 200 mg in days 3 and 5. Symptom-limited cycloergometric exercise tests were performed at 3 and 24 hours after placebo and after each of the two doses of metoprolol RETARD. Duration of exercise, maximal workload and total work performed did significantly increase at 3 and 24 hours after metoprolol RETARD 100 mg (P less than 0.01) and 200 mg (P less than 0.01), without any significant difference between the two doses. Peak systolic arterial pressure and heart rate were lowered by metoprolol RETARD 200 mg at 3 (P less than 0.01) and 24 (P less than 0.01) hours, whereas only the peak heart rate at 3 hours was lowered (P less than 0.05) by the 100 mg dose. It is concluded that in patients with stable exercise-induced angina pectoris, metoprolol RETARD 200 mg appears to be able to increase exercise tolerance and to reduce exercise-induced myocardial oxygen consumption throughout 24 hours period. This may justify a once daily dosing schedule of the 200 mg dose, aimed at improving patient compliance.

Adult↗
PubMedDate not supplied

Total oxyradical scavenging capacity and cell membrane stability of haemocytes of the Arctic scallop, Chlamys islandicus, following benzo(a)pyrene exposure.

Industrial activities, notably oil and gas industries, are expanding in the Arctic. Most of the biomarkers were developed using temperate organisms living at temperatures above 10 degrees C. Little is known about the biomarker responses of organisms living between -1.88 and 5 degrees C. Therefore, assessment of the toxicity of chemicals to cold-water adapted species is required. In this study, the Arctic scallop, Chlamys islandicus, was selected as a key species for bio-monitoring because of wide distribution in Arctic waters and its commercial value. Test animals, stored in seawater at 2 degrees C, were injected with benzo(a)pyrene (diluted in cod liver oil 5 mg ml(-1)) in the adductor muscle every 24 h for four days giving a final dose of 0, 74 and 90.6 mg kg(-1) wet weight for control, low and high dose, respectively. The biomarkers used were total oxyradical scavenging capacity (TOSC) in the digestive gland and cell membrane stability of haemocytes. TOSC values were significantly reduced (ca. 30%) in exposed groups (P < 0.05), indicating a depletion in oxyradical molecular scavengers. The antioxidant defences appeared to be overwhelmed by the reactive oxygen species as the plasma membranes of haemocytes were destabilised (P < 0.05) probably due to lipid peroxidation. These data indicate that reactive oxygen species (ROS) were produced by Arctic scallops via the metabolisation of benzo(a)pyrene at 2 degrees C.

Adaptation, Physiological↗