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Biomedical subjects

F Regnier

Publications and source records attributed to F Regnier.

28 records · Page 2Linked to original sources
PubMed1986

[Biosynthetic growth hormone and the opinions of pediatricians. The form of the problem after a regional survey].

An enquiry was undertaken with 35 pediatricians in the area of Bordeaux, concerning the attitudes induced by the future availability of a synthetic growth hormone obtained by genetic engineering and which might allow for treatment of a greater number of children presenting with important growth retardation. Biosynthetic growth hormone is perceived as a innovative technologic advance. However, the pediatricians questioned showed prudence as to the risks of excesses as to indications.

Attitude of Health Personnel↗
PubMed1979

Sex pheromone in the dog.

Methyl p-hydroxybenzoate has been identified in the vaginal secretions of female dogs in estrus. When small amounts of this compound were applied to the vulvas of anestrous or spayed females, males placed with these females became sexually aroused and attempted to mount them.

Animals↗
PubMedDate not supplied

Peptides as affinity surfaces for protein purification.

The tetrapeptide GPRP was previously shown to be an effective affinity ligand for fibrinogen when immobilized to Fractogel (Kuyas et al., 1990). The authors synthesized the GPRP peptide directly onto an aminefunctionalized POROS chromatographic resin to demonstrate the effectiveness of this approach for generating perfusive affinity media. Fibrinogen from plasma bound to an NH2-GPRP-POROS column under 50 mM phosphate buffer, 0.15 M NaCl, pH 7 at 15 ml/min flow rate. The bound fibrinogen showed weak clotting activity when eluted with 20 mM acetate buffer, pH 4. The peptide column did not bind denatured fibrinogen. The dynamic binding capacity of the column by frontal analysis was 10.2 mg/ml column volume. The total analysis time was under 5 min. Similarly, the CAQCHTVEK peptide of cytochrome c with heme group covalently attached to the SH groups of the two cysteines is known to bind to albumins (Adams et al., 1989). A simplified peptide analogue, GAQGHTVEK, was synthesized directlyon POROS resin. Under 20 mM MES, pH 6, albumin from human serum bound specifically to this peptide column and eluted with a salt gradient at 0.2 M NaCl, 20 mM MES (2-[N-Morpholino]ethane sulfonic acid), pH 6. The dynamic binding capacity of human serum albumin by frontal analysis was 19 mg/ml column volume. Thus, this column can purify albumin from human serum under non-denaturing conditions.

Chromatography, Affinity↗
PubMedDate not supplied

[Menetrier's disease and edematous syndrome (author's transl)].

The authors report a case of Menetrier's disease revealed in a 51 years woman before oedomas by systematic gastroscopy. Somes particularities of this case authorize to argue problems put by this disease: a thyroid nodule treated by L + triodothyronin; an eosinophilia; a biological study of gastric secretion, gastrin and intrinsec factor level; an hormonal, immunologic and genetic exploration; an histochimic and ultra-structural study of operative portion; its favorable evolution after total gastrectomy.

Edema↗
PubMedDate not supplied

[Double-blind versus placebo comparison of single dose alpidem (50 mg or 75 mg) in a model of situational anxiety].

Alpidem (Ananxyl) is a new imidazopyridine anxiolytic. Two studies of single doses of alpidem (50 or 75 mg) versus placebo, involving 104 patients each, showed alpidem at these two doses to be effective in a human model for situational anxiety, which is the psychological state of patients awaiting cardiovascular examination or surgery. Clinical assessment showed no significant difference in safety between alpidem 50 mg and placebo. Conversely, at the dose of 75 mg, there was a higher incidence of drowsiness with alpidem than with placebo.

Adult↗