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Biomedical subjects

F Ramos

Publications and source records attributed to F Ramos.

At least 145 records · Page 8Linked to original sources
PubMed1980

[Short-term therapy of atrial fibrillation with an association of digitalis and amiodarone (author's transl)].

Forty patients with organic cardiopathies and permanent atrial fibrillation were divided at random into two similar groups in relation to their diagnoses and ages. Twenty patients were treated with digoxine alone, and the other 20 with digoxine plus amiodarone hydrochloride. Comparison of results from each group showed statistical significant differences (p less than 0.0005) regarding total digoxine dosage and length of treatment. Mechanism of action of this synergia is discussed, and the association of digitalis and amiodarone is recommended to reduce digitalization time in patients with paroxysmal auricular tachycardia.

Adult↗
PubMed1980

Two asparagine synthetases in Saccharomyces cerevisiae.

In Saccharomyces cerevisiae L-asparagine auxotrophy, resulting from a lack of L-asparagine synthesis, needs simultaneous defects in two genes. This unusual situation is shown to result from the occurrence of two L-asparagine synthetases. The meaning of this duplication remains obscure. The properties of the two enzymes are remarkably similar: both have a molecular weight of 150,000 and they exhibit a slight repression and a similar inhibition by asparagine. Neither one is located in mitochondria and both are probably cytosolic. Their identification so far lies only in their behaviour on ion-exchange chromatography and in the encoding genes.

Asparagine↗
PubMed1979

Synthesis and activation of asparagine in asparagine auxotrophs of Saccharomyces cerevisiae.

L-Asparagine synthesis in Saccharomyces cerevisiae is performed by a glutamine-dependent asparagine synthetase of the type found in higher organisms. Auxotrophy for asparagine has been obtained in two classes of mutants. In class I, asparagine synthetase activity is cancelled. These mutants combine two mutations, asnA- and asnB-. Neither asnA- nor asnB- mutation alone leads to total auxotrophy. Partial auxotrophy as well as a strong decrease in enzyme activity result from asnA- mutation. No change is detectable in cells with the asnB- mutationalone. This, and Jones' report [J. Bacteriol. 134, 200-207 (1978)] of auxotrophy resulting from the combination of two mutations, are strong supports for asparagine synthesis being an unusual biosynthetic operation. In class II, auxotrophy results from a single mutation which leads to a modification of the efficiency of the asparaginyl-tRNA synthetase (asnRS- mutation). This auxotrophy is cancelled if asparaginase I activity (the only one present in sigma 1278b wild type) is cancelled by casnI- mutation. This latter mutation allows an increase in the asparagine pool which is able to compensate for the asparaginyl-tRNA synthetase partial defect of the asnRS- mutant.

Amino Acyl-tRNA Synthetases↗
PubMed1976

High serum glutamic acid levels in patients with carcinoma of the pancreas.

High levels of glutamic acid and normal levels of glutamine were found in the blood of all but one of ten patients with carcinoma of the pancreas. No changes of the concentration in blood of these two amino acids were observed in 49 patients suffering from several diseases including malignant tumours. Although the mechanism of the rise of serum glutamic acid is difficult to explain at present, it may have some diagnostic value.

Female↗
PubMed1975

Penicillin immunogenicity in the presence of different pharmaceutical adjuvants.

Preliminary results in the variations of the penicillin immunogenicity in the presence of aminosugars, polysaccharides and terpenic substances are presented and the decreasings of the potential antigenicity of the penicillin molecule appeared in the presence of hexosamine molecules are estimated. It might be possible as a consequence of modifications in the early immunogenic interactions between antibiotic and serum proteins of the hipersensitive animals.

Adjuvants, Pharmaceutic↗