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Biomedical subjects

F Ramos

Publications and source records attributed to F Ramos.

At least 109 records · Page 6Linked to original sources
PubMed1990

Hydrocephalus and cavernoma of the cauda equina.

The association of a tumor of the cauda equina and hydrocephalus is unusual. We report a case of hydrocephalus with normal pressure associated with an equally rare affliction, a cavernous angioma of the cauda equina, which regressed after surgical ablation. The physiological mechanism involved is discussed.

Aged↗
PubMed1990

Genotypic analyses of Hodgkin's disease.

In spite of the use of molecular biology, the cellular lineage and clonality of Reed-Sternberg cells, the abnormal cells of Hodgkin's disease, remain an enigma. We studied the pattern of rearrangements at immunoglobulin and T-cell receptor loci in 23 patients suffering from Hodgkin's disease. Two out of 23 patients exhibited immunoglobulin gene rearrangements. No rearrangements of the T-cell receptor beta-chain gene were detected in any patient examined. Our results showed no correlation between the presence of rearranged bands and the number of Reed-Sternberg cells.

Antigens, CD↗
PubMed1990

[Silent ischemia. To treat or not to treat?].

Silent myocardial ischaemia can be defined as the presence of transient ischaemic alterations in absence of angina. Those include metabolic, functional, electrocardiographic and anatomic abnormalities without typical chest pain. Its incidence, prognostic significance, possible identification in clinical practice as well as need for treatment varies according to the group of patients. In the present review, we discuss these concepts in base of the knowledge supported by the results of different studies. As a rule, the incidence, prognostic significance, and henceforth the need for its identification, increase from the low risk groups of patients to those of high risk according to classical criteria. To this respect, it is useful to differentiate three groups of patients: normal subjects, stable coronary heart disease and unstable heart disease. Medical treatment with anti-ischaemic drugs as well as myocardium revascularization procedures have shown to decrease the incidence and severity of silent myocardial ischaemia, but its influence on prognosis is unknown, and it should be emphasized that the main objective in the treatment of silent ischaemia is improve prognosis.

Coronary Disease↗
PubMed1990

[Silent ischemia after myocardial infarct].

The Framingham study demonstrated that 25% of all episodes of acute myocardial infarction (AMI) do not present clinical symptoms, and are later recognized in a routine ECG. Silent ischaemia is frequently found after acute myocardial infarction, and has been identified in 25-60% of the patients according to the results of different studies and the different criteria employed for diagnosis. Silent ischaemia after AMI, as well as angina, is related with the presence and extent of severe coronary lesions located in the infarct related coronary artery or in other vessel not responsible for the acute episode of necrosis. The prognostic significance of silent ischaemia after AMI has not been well established. In some studies the painless ST segment depression during an exercise test soon after AMI presented the same prognostic value that the ST segment depression accompanied by angina, but in others the symptomatic episodes were a better predictor of major events and long term survival after the infarct. Several studies employing ambulatory ECG monitoring (Holter) also seem to indicate that the painless and transient episodes of ST segment depression identify a group of patients with worse prognosis, but in these studies the patients were selected, introducing a clear bias in the results of these investigations. Finally, asymptomatic transient perfusion defects in thallium studies clearly identify a group of high risk patients with a higher incidence of complications and higher mortality rate than the patients with negative thallium studies. The efficacy of anti-ischaemic drugs or myocardium revascularization procedures, including surgery, has not been studied in patients with silent ischaemia after acute myocardial infarction.(ABSTRACT TRUNCATED AT 250 WORDS)

Coronary Disease↗
PubMed1989

Relationship of body fat distribution to metabolic complications in obese prepubertal boys: gender related differences.

Our purpose was to assess the relationship of obesity and body fat distribution to serum glucose values, insulin concentration and insulin resistance in obese prepubertal boys. Thirteen obese and 15 control prepubertal boys were studied. Biceps, triceps, subscapular and suprailiac skin fold thicknesses were measured. Percentage of body fat and total body fat were calculated. Body fat distribution was assessed by analyzing the central (supra-iliac, subscapular)/peripheral (biceps, triceps) ratios. During an oral glucose tolerance test, serum glucose and insulin were measured and insulin/glucose was calculated. Body fat data and body fat distribution indices were significantly higher in the obese group. The obese population presented significantly elevated values of insulin and insulin/glucose. In the obese group insulin showed significant correlations with percentage of body fat, total body fat and subscapular skin fold thickness, whereas insulin/glucose had significant positive correlations with percentage of body fat, total body fat and supra-iliac skin fold thickness. In obese boys significant positive correlations were also shown by subscapular/supra-iliac with insulin and insulin/glucose, and by subscapular/triceps with insulin. In prepubertal boys obesity is centripetal and an upper central body fat distribution seems to be first associated with an abnormal glucose-insulin homeostasis.

Adipose Tissue↗
PubMed1989

Chronic cervical radiation myelopathy diagnosed by MRI.

We report a case of chronic cervical myelopathy which developed after radiotherapy for differentiated carcinoma of the buccal cavity. The myelopathy was diagnosed by the finding of severe cervical cord atrophy at MRI.

Adult↗
PubMed1988

Control of enzyme synthesis in the lysine biosynthetic pathway of Saccharomyces cerevisiae. Evidence for a regulatory role of gene LYS14.

Several enzymes of the lysine pathway of Saccharomyces cerevisiae were found to respond to an induction mechanism mediated by the product of gene LYS14 in the presence of 2-aminoadipate semialdehyde, an intermediate of this pathway. This novel regulatory mechanism appears independent of the specific repression by lysine and of the general control of amino acid biosynthesis. Genes LYS1, LYS9 and LYS14 have been cloned and their DNAs used to assay the corresponding messenger RNAs. The results suggest that the induction mechanism, as well as the specific and general regulations, operate at the transcriptional level. The synthesis of saccharopine dehydrogenase (glutamate-forming), previously shown to require the unlinked genes LYS9 and LYS14, is also affected by the induction mechanism. The leaky auxotrophic behaviour of lys14 mutants is explained by the low basal level of expression of LYS9, the structural gene of this enzyme, in the absence of induction by 2-aminoadipate semialdehyde.

2-Aminoadipic Acid↗
PubMed1988

Giant meningioma in a 5-month-old infant.

A case of intracranial meningioma is reported in a 5-month-old infant. To date, 25 cases have been reported in the world literature in children less than 1 year of age. Macrocephaly was the most prominent clinical finding. Skull radiological studies, head CT scans, and cerebral angiography were definitive tools in making the diagnosis. Pathological analysis was conclusive. Complete surgical extirpation was the treatment of choice; the tumor weighed 600 g. The child remains stable 24 months later.

Cerebral Angiography↗
PubMed1988

Immunological markers in a coexisting chronic lymphocytic leukemia and Hodgkin's disease.

A 57 year old patient in whom Hodgkin's disease (HD) and Chronic Lymphocytic Leukemia (CLL) was simultaneously diagnosed is described. The infiltration of peripheral blood and bone marrow by mature lymphocytes, with special immunological phenotype (SIg negative, mouse rosette positive and monoclonal antibodies B1+, B4+) consistent with B-CLL and histological findings of lymphnode and axillary mass biopsies were typical of HD. The immunological study of the cell suspension from the axillary mass displayed a phenotype similar to that of the peripheral blood lymphocytes. Whether HD and CLL are two processes of fortuitous association, or a single clinical entity remains to be elucidated. The immunological findings in our patient suggest a common origin for both disorders and that HD could sometimes be the result of a B cell proliferation.

Biomarkers, Tumor↗