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Biomedical subjects

F R Freemon

Publications and source records attributed to F R Freemon.

68 records · Page 4Linked to original sources
PubMedDate not supplied

Acute effects of viloxazine HCl and flurazepam when given alone and in combination on sleep EEG: a double-blind interaction study with normals.

Viloxazine, an aryl-oxypropanolamine type of beta-adreno-receptor antagonist, has been used in the treatment of depression. In a double-blind drug interaction study with flurazepam, a commonly used benzodiazepine hypnotic, viloxazine administered alone decreased the amount of time spent in REM sleep, increased the amount of time in the "light" stages of sleep, and increased the number of transitions to awake. However, no interactive effects of the combined administration of viloxazine and flurazepam could be detected.

Adult↗
PubMedDate not supplied

Two roads to coma: the Scottish hypothesis.

Clinical experience seems to indicate two separate types of entry to coma. Some patients follow a pathway characterized by confusion, hallucinations, mumbling delirium, myoclonic jerks, and seizures. The author has called this sequence of symptoms the high road to coma and hypothesized that its basic underlying pathophysiology involves increased neuronal firing rates. Other patients develop somnolence, lethargy, obtundation, and unresponsiveness without seizures or muscle twitches. This low road to coma involves either anatomical compression of the midbrain reticular formation or a metabolic or toxic disorder characterized by membrane stabilization and decreased neuronal excitability.

Coma↗