SEMI-SYNTHETIC PENICILLINS.
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Biomedical subjects
Publications and source records attributed to F R FEKETY.
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As determined by serial histologic study, the leukocyte component of the acute inflammatory response to thermal injury in the medulla of the kidney of rabbits was markedly delayed and diminished in intensity when compared with the response of the cortex. Similar differences in granulocyte mobilization between cortex and medulla were seen following the inoculation of bacteria. Hydronephrosis produced by ureteral ligation had no discernible effect upon the inflammatory response in either cortex or medulla following thermal burns. The susceptibility of the cortex to E. coli infection was markedly enhanced during leukopenia induced by nitrogen-mustard. These results suggest that deficiencies in granulocyte mobilization play an important role in the increased susceptibility of the renal medulla to bacterial infection.
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Antibiotic-resistant staphylococci of the same bacteriophage type were isolated from the external nares of asymptomatic domestic animals and from human beings during an epidemic of staphylococcal disease in veterinary students. Not all of the infections could be attributed to person-to-person contact; spread could be explained also by transmission of staphylococci from animals.
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