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Biomedical subjects

F R Ellis

Publications and source records attributed to F R Ellis.

At least 109 records · Page 6Linked to original sources
PubMed1977

Calcium and magnesium contents of malignant hyperpyrexia-susceptible human muscle.

The calcium and magnesium contents of muscle obtained by muscle biopsy of patients referred for malignant hyperpyrexia screening were determined. The susceptibility to malignant hyperpyrexia was made on the basis of the halothane contracture test. No difference in cation concentrations was found between the normal and malignant hyperpyrexia-susceptible groups.

Adolescent↗
PubMed1977

A study of body temperatures of anaesthetized man in the tropics.

Body core and skin temperatures were measured in 20 African patients undergoing herniorrhaphy in hot and humid conditions; one half of the patients received halothane and the other half received diethyl ether. No difference was found between those two groups. Body core temperatures decreased even with an ambient temperature of 28.7 degrees C and a relative humidity of 72% and all sites reached a new thermal equilibrium at 30 min. It is suggested that the level of the re-established thermal equilibrium is a function of the skin to ambient thermal gradient, which depends on the failure of the countercurrent heat exchange mechanism as a result of redistribution of peripheral blood flow.

Adult↗
PubMed1977

Long chain polyunsaturated fatty acids in endogenous depression.

The fatty acid composition of the plasma choline phosphoglycerides (CPG) and erythrocyte ethanolamine phosphoglycerides (EPG) were detemined in a series of patients suffering from endogenous depression, a number of patients from the same ward with non-depressive psychiatric disorders, and a number of age- and sex-matched healthy control subjects. A significantly higher proportion of long chain polyunsaturated fatty acids, in particular eicosapentaenoic acid (20:5omega3) and docosahexaenoic acid (22:6omega3), was found in the subjects with endogenous depression compared with the controls. This change was reflected to a lesser extent in the erythrocyte EPG. The proportions of the two prostaglandin precursors gamma-dihomolinolenic acid (20:3omega6) and arachidonic acid (20:4omega6) were similar in both groups. The fatty acid composition of the plasma CPG and erythrocyte EPG of a number of subjects from the same ward with non-depressive psychiatric disorders did not differ from that of the healthy controls. It is suggested that the analysis of the fatty acid composition of plasma CPG may be of diagnostic value and could be involved in the pathology of endogenous depression.

Depression↗
PubMed1975

Evaluation of creatinine phosphokinase in screening patients for malignant hyperpyrexia.

Evidence is presented that serum creatinine phosphokinase (CPK) activity is of no direct value in screening patients for susceptibility to malignant hyperpyrexia and does not correlate with halothane-induced muscle contracture or the presence of myopathy. Widely differing CPK values were found at different times in the same people. In most "malignant hyperpyrexia" families the susceptible patients had either normal or inconsistently raised CPK values.

Creatine Kinase↗
PubMed1975

A computerized national Blood Donor Deferral Register.

With blood given exclusively by volunteer donors, the American National Red Cross (ANRC) Blood Program aims to supply patients needing transfusion with blood products of the highest quality. The use of blood from volunteers, with its established greater safety, combined with laboratory testing to detect carriers of hepatitis B surface antigen (HB-SAg) and modern computer technology, creates an effective system to reduce the risk of post-transfusion hepatitis. The ANRC has devised a national Donor Deferral System, which is designed to minimize the transmission of hepatitis by blood and blood products.

Blood Banks↗
PubMed1975

An evaluation of procaine in the treatment of malignant hyperpyrexia.

Procaine has been advocated in the treatment of malignant hyperpyrexia, whereas lignocaine has been shown to worsen the condition. Using muscle from patients susceptible to malignant hyperpyrexia in vitro, it has been demonstrated that muscle contracture can occur with procaine on its own, and in one patient the halothane-induced contracture was potentiated by procaine. In other patients the concentration of procaine required to abolish the halothane-induced contracture was markedly above the clinical dose range. In a study of lignociane and procaine on a caffeinated rat muscle (a suggested model for malignant hyperpyrexia) no significant difference was found in the ability of these local anaesthetics to alter resting tension of halothane-treated muscle; with both drugs the resting tension rose in a dose-related manner. The use of procaine as the drug of first choice in patients with malignant hyperpyrexia is challenged.

Anesthesia, General↗