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Biomedical subjects

F Pupita

Publications and source records attributed to F Pupita.

At least 37 records · Page 2Linked to original sources
PubMed1985

Controlled trial on three beta-blockers: antihypertensive efficacy and effect on the hypertensive heart disease.

Treatment of 66 hypertensive patients with three different beta-blockers (atenolol 100 mg once a day; oxprenolol 80 mg twice a day; nadolol 80 mg once a day) for six months resulted in a significant reduction in blood pressure and heart rate, the maximum with nadolol, a significant amelioration in pre-ejection period/left ventricular ejection time ratio expressing the haemodynamic performance of the left ventricle with atenolol and nadolol, and a significant reduction left ventricular hypertrophy as expressed by the Romhilt-Estes index with all three drugs, but especially with nadolol.

Adrenergic beta-Antagonists↗
PubMed1985

Multicentre clinical study with flunoxaprofen in osteoarthritis: preliminary data on 154 patients.

Flunoxaprofen S-(+)-2 [p-fluorophenyl]-alpha-methyl-5-benzoxazole acetic acid, a new propionic acid derivative, was studied to investigate its long-term effectiveness and tolerability in the management of osteoarthritis (OA). To the study were admitted 154 patients suffering from radiologically proven OA of the large joints; 37% of them were hospitalized. The patients received flunoxaprofen 100 mg twice daily for a period of 45-60 days. The variables investigated were: pain at rest, pain on passive motion and pain on active motion with or without load, quality of sleep, articular flexion. In addition, the usual clinical and laboratory controls were carried out (arterial blood pressure, hepatic and renal function tests, haematological examinations). The assessments were made before and at 15, 30, 45 and 60 days of treatment. The results obtained show significant improvements for all variables considered and a very good tolerability of the drug concerning either laboratory controls or adverse reactions.

Adult↗
PubMed1985

Clinical pharmacology of loop diuretics: a comparative study.

The authors performed two studies to clarify the characteristics, analogies and differences of three loop diuretics (furosemide, bumetanide and piretanide) aiming at more precise indications for their clinical use. In the first study, they compared bumetanide and piretanide by the method of compensated diuresis; in the second, they tested the three loop diuretics' efficacy in refractory ascites. The authors demonstrated that with the three substances analogous results were obtained when administered at equivalent doses and that only intensive diuresis was able to resolve refractory ascites.

Adult↗
PubMed1983

Clinical pharmacology of DEAE-dextran for long-term administration (one year).

Twenty-eight patients with hyperlipoproteinaemia types II and IV according to Fredrickson were treated for one year with diethylaminoethyl-dextran (DEAE-D). The drug, used at a daily oral dosage of 2 to 3 g, proved very effective in reducing both blood cholesterol and triglycerids (mean reduction was 24 percent and 31 percent respectively). The drug also proved itself to be remarkably free from side-effects, as assessed both by a comprehensive check of biochemical parameters as well as by the patients themselves. The results obtained confirm the hypolipaemic effectiveness of DEAE-Dextran, due to an increased elimination of bile acids and fatty acids by the G.I. route.

DEAE-Dextran↗
PubMed1983

Long-acting and short-acting diuretics in the treatment of hypertension.

A single-blind trial was carried out in 36 people with mild to moderate hypertension to compare the efficacy and tolerance of long-term treatment with furosemide and chlorthalidone. After a 30-day wash-out period, patients were treated for 6 months with a single daily dose of either 25 mg furosemide or 50 mg chlorthalidone. They were then crossed over to the alternative drug, after a 15-day wash-out period, for a further 6 months. Results from the 25 patients who completed the study period showed that both treatments were successful in reducing systolic and diastolic blood pressure significantly after 1 month and blood pressure was controlled at the lower level for the remainder of the study period. There was no statistically significant difference between the two treatments at the end of the trial in respect of their antihypertensive efficacy. However, patients on chlorthalidone showed a marked, significant decrease in serum potassium levels from 1 month onwards compared to patients treated with furosemide and at the end of 6 months 10 (25%) were considered to be hypokalaemic whereas only 2 (8%) of the furosemide-treated patients had serum potassium levels lower than 3.5 mmol/l. Few side-effects were reported and patient compliance was good in both treatment groups.

Adult↗