[Neonatal lupus erythematosus].
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Biomedical subjects
Publications and source records attributed to F Prigent.
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Evidence from cytogenetic (karyotype) and cytometric studies in cutaneous T-cell lymphomas reported in the medical literature is reviewed. Such studies are still very scarce because of the technical difficulties which arise in culturing the cells. Automatic analysis of chromatin dispersion (flow cytometry) is currently the most promising technique.
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The authors report two new cases of Goldenhar's syndrome, as they are described in Gorlin's scheme of oculo-auriculo-vertebral dysplasia. Therapeutical problems (plastic and orthopedic surgery, ocular prothesis and hearing aid) due to Goldenhar's syndrome are very acutely pointed out in these cases. Generalized convulsions, not yet described in the medical literature, are found in these two cases. These congenital malformations are caused by branchial arches organogenesis anomalies. The authors consider that accurate and early dermatologic diagnosis is important for the correct management of children with oculo-auriculo-dysplasia.
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The case-report of an eleven-year-old boy presenting with the association of Stevens-Johnson syndrome and pulmonary symptoms is studied. The course of the disease covered two distinct periods since a one-month interval occurred between the two cutaneo-mucous and pulmonary episodes. Mycoplasma Pneumoniae infection was confirmed by positive seroconversion. The child recovered without sequelae. Indirect immunofluorescence transitorily showed anticytoplasmic antibodies directed against basal epidermic cells. These antibodies were not fixed on the lesions as shown by direct immunofluorescence. The possible connexion between Stevens-Johnson syndrome, Mycoplasma Pneumoniae infection and anticytoplasmic antibodies is under discussion.
The parameters of myocardial function in the initial phase of ventricular ejection are theoretically more sensitive than the indices calculated over the total systolic ejection period. The object of this study was to evaluate whether the calculation of the ejection fraction by thirds of systole, giving a separate assessment of left ventricular performance at the beginning, the middle and end of ejection, could reliably detect minor changes in ventricular function unrecognised by the usual holosystolic indices. Seventy left ventricular angiograms were analysed in 20 normal subjects (Group I) and 50 patients with coronary artery disease whose ventricular function estimated by the usual parameters was either decreased (Group II, 20 patients) or normal (Group III, 30 patients). In Group I, the ejection fraction in the first third of systole (FE1/3) was much higher than the ejection fraction in the second third (FE2/3). On the other hand, in Groups II and III, all patients had a FE1/3 lower than the FE2/3 (specificity: 100 p. 100). In these two groups, the reduction of FE1/3 and the increase of FE2/3 were very significant compared to Groupe I (p less than 0,001). The ejection fraction of the lest third was identical in the 3 groups. This abnormal distribution of ejection was detected in all coronary patients and was the only alteration of ventricular performance in each of the 30 patients in Group III. In this group, this abnormality was detected equally in patients with triple vessel disease (Subgroup III a, 20 patients) and in patients with isolated left anterior descending disease (Subgroup III b, 10 patients) illustrating the high sensitivity of this index for the detection of a minor abnormality of myocardial function.